OBJECTIVE: Available information on the background of the current state and advances of the intestinal lymph trans port of medicines were reviewed. Drug transported by the intestinal lymphatic system can avoid hepatic first-pass metabolism, increase the bioavalibitlty of the highly lipophilic drug, and it is of importance for immunomodulatory, anticancer and anti-infective drugs. METHODS: We conducted a systematic literature review of articles published recent years, analysis and summaries are made upon the advances and methods applied for the increase of the intestinal lymph transport. RESULTS AND CONCLUSION: Intestinal lymphatic transport can increase the bioavailability via a reduction in the first-pass metabolism and the possibility of specifically targeting drugs to regions of the lymphatics, thus it is very advantageous for drugs that are under significant first-pass metabolism. The present review embodies a brief background of the mechanism of access of drugs to the intestinal lymph, a discussion on the links between lipid absorption and transport of highly lipophilic drugs, and approaches for enhancing lymphatic drug transport. Finally, experimental models of the lymphatic transport are also discussed.

Objective:To investigate if there is difference about the parameters of acoustic analysis with the different vowe |a|、|i|、| | and decide which vowels is best fitted to the acoustic analysis. Method:40 normal and 130 pathologic voice patients accepted acoustic analysis. Each acoustic parameters such as jitter,shimmer、NNE、 SDF0、SNR were compared with different vowels. Result:Jitter、shimmer、NNE with |i| were much lower than that with |a| and | | in normal cases and light hoarseness group. While the acoustic parameters with |i| were much higher than that with |a| and | | in moderate and heavy hoarseness group. Conclusion: |a| and | | were the preferred vowels for normal and light hoarseness group,while the |i| could supply some useful suggestion for the moderate and heavy hoarse patients.

AIM: To provide a HPLC fingerprint of Fructus aurantii micropowder in order to create a basis for(identification.) METHODS: With the help of computer similarity evaluation,Seventeen kinds of Fructus aruantii sample were pulverized and micronized separately,then were extracted by methanol and compared correlation between both extracts. RESULTS: In methanol extraction,contents of aurantiamarin,hesperidin and neohesperidin in micropowder were more than that in pulverized powders,correlation of both HPLC fingerprint was 0.9~1.0. CONCLUSION: The method established can be used for identifying and evaluating crud drug of Fructus aurantii,and further prove that micronization is beneficial to increasing flavonoid dissolution.

Objective To study the effect of ovarian estrogen on the expression of estrogen receptor beta (ER beta) of the basal forebrain of mice. Methods Ovariectomized (OVX) mice were used as animal model, and nickel ammonium sulfate intensified immunohistochemical SP technique was used to detect the changes of ER beta expression in the basal forebrain. Results The expression of ER beta in the basal forebrain of mice decreased dramatically, after OVX decreased to the lowest levels at 3 d after OVX, increased gradually, and recovered to normal level 20 d later. Conclusion Ovarain estrogen can regulate the expression of ER ? of the murine basal forebrain, indicating that estrogen, via ER ?, can regulate the nerous structure and function of the basal forebrain, which may be the mechanism of estrogen replacement therapy on Alzheimer′s brain.

Objective To investigate the effect of endovascular brachytherapy with Rhenium-188-filled catheter balloon on cell proliferation,phenotype of smooth muscle cell and secretion of transforming growth factor; to explore the possible mechanism of this method employed in restenosis prevention. Methods After the right common carotid arteries were overstretched by 3.5?20 mm balloon,twenty New Zealand White rabbits were randomized into irradiation (n=10) and control group (n=10). Endovascular bachytherapy was performed wth a 188[KG*2/2]Re filled 3.0?20 mm balloon catheter delivering a dosage of 16 Gy (0.5 mm underneath the luminal surface) in the irradiation group, whereas isovolume normal-sodium-filled balloon catheter was used in the control group for an equal period. After thirty days, analysis of the carotial arteries was made by measns of histological and immunohistochemical staining. Results (1) The positive staining index of proliferation cellular nuclear antigen (PCNA) and transforming growth factor (TGF) of the irradiation group is significantly less than the control group (0.028?0.005 vs 0.054?0.011, 0.033?0.008 vs 0.063?0.014, respectively); (2) The positive staining of ?-actin index in intima has no significant difference between the irradiatin group and the control group. Conclusion (1) The preventive effect on restenosis with endovascular brachytherapy is possibly achieved by suppression of cellular proliferation and transforming growth factor secretion. (2)The phenotype of smooth muscle cell is possibly unaffected by endovascular brachytherapy.

Fibromatosis, Gingival ; diagnosis ; Gingival Overgrowth ; diagnosis ; therapy ; Humans

2 in B27 positive groups and X = l. 58

Objective To investigate the occurrence of p16 gene methylation in the population chronically exposed to arsenic in Inner Mongolia,and to study the molecular mechanisms of carcinogenesis associated with arsenic exposure.Methods The study group was composed of 40 cases of typical arseniasis selected from the epidemic area,and the two control groups consisting respectively of 40 non-arseniasis cases selected from the same epidemic area,and 40 healthy persons enrolled from non-epidemic area.Methylation of p16 gene in the blood specimens were analyzed for all the subjects with MS-PCR techniques,and statistical analysis was performed using chi square test.Results The positive rates of p16 hypermethylation in blood specimens were 65.0%,47.5% and 20.0% respectively in study group and two control groups,and the rate of hypermethylation increased with the increase in arsenic exposure with drinking water in epidemic areas.The positive rate of p16 hypermethylation showed significant differences(P

It was show that the 3 medical preparations, viz: Chuanxiong, the mixture of Chuanxiong & Ginseng ( CG Mixture ) , and the mixture of Chuanxiong & Miltiorrhizae could increase the coronary retrograde flow & decrease the resistance to collateral flow. The CG mixture exhibited positive effects on cardiac output, coronary flow blood, & retrograde pressure, but the other 2 medicines showed negative effects.These findings suggest that the CG mixture could improve & regulate the cardiovascular function, open the collateral vessels to reduce the ischemic size, while the other 2 medicines might reduce the cardiac power consumption. It is expected that the CG mixture may be more suitable for treatment of coronary diseases with cardiac insufficiency & hypotension, and the other 2 may be used for that with hypertension.

These groups of Chinese medicines were prepared-Cbuanxiong, a mixture of Chuanxiong & Ginseng, & a mixture of Chuanxiong & Miltorrhiza. The effects of these groups of drug on sischemic areas ( subepicar-dial ) and ( subendocardial) PO2 were compared in anaesthetized open-chest mongrel dogs. The heart tissue P02 was determined simultaneously at a depth of 2-3mm(epicardial) and 8-9mm (endocardial) 晈ith small platinum electrodes by polarography. The 3 combinations of medicine could not only increase the heart tissue PO2 in both areas when ischemia occured, but also increase deep area P02 to a greater extant than superficial area PO2. Lignsticum Chuanxiong and Panax Ginseng were more effective than the other 2 groups.