Objective:To explore the effect of argatroban combined with Kallikrein on progressive cerebral infarction.Methods: One hundred and fifty two progressive cerebral infarction patients were randomized into groups observation (n=76) and control (n=76). Observation group were given treatment ofargatroban and Kallikrein, control only Kallikrein. NIHSS scores, Barthel index, Modified Rankin Scales(MRS) were used to evaluate the efficacy in two groups.Results: The difference of the effect was significant in two groups(x2=11.463,P>0.05).In both of the two groups, NIHSS scores were decreased, there was significant difference between the two groups (t=1.501,t=1.844,t=1.341;P<0.05). The Barthel index in argatroban combined Kallikrein group was higher than Kallikrein group, Modified Rankin Scales was lower than Kallikrein group, and there was significant difference between the two groups (t=2.121,t=2.332,t=2.219;P<0.05). The observation group and the control group patients don''t have bleeding gums,subcutaneous bleeding, gastrointestinal bleeding and other adverse reactions.Conclusion: Argatroban combined with Kallikrein, improve the neurologic impairment symptoms, clinical effect, improve the life quality of the patients, of a relatively good effect in treatment of progressive cerebral infarction, can improve obviously the cognitive ability and neural function and patients, activities of daily living. Moreover, its security and tolerability are good.

A young female patient with paradoxical cerebral embolism caused by pulmonary arteriovenous fistula,mainly presented the right limbs asthenia,and brain magnetic resonance imaging examination showed multiple acute cerebral infarctions in the left hemisphere,which belongs to left middle cerebral artery and left posterior cerebral artery blood areas.After excluding the common risk factors of cerebrovascular disease,foaming test suggested the right-to-left shunt.The esophageal ultrasound examination excluded the patent foramen ovala.The lung CT angiography examination confirmed the intracranial embolism caused by pulmonary arteriovenous fistula.There was no recurrence of ischemic stroke after the patient was treated with pulmonary arteriovenous fistula embolization.