Objective To verify that natural zeolites can be used in treatment of fluoride in groundwater in the east-southern of Shanxi Province. Methods Determination of the fluoride by lime-paper sampling and fluorine ion-selective electrode analysis(reference to GB/T 7484-1987). In the paper the best activation process and the appropriate application were discussed, and then the activated zeolite should be used in experimental and real application, in which the effect of zeolite on water quality were assured. The used zeolite could be regenerated and reused. Results The best activation process before use was orderly treated by 5.0 mol/L HCl for 5 hours, then 0.3 mol/L KAl(SO4)2 10 hours,and finally 300 ℃ in furnace for 4 hours. 5 g activated zeolite in 100 ml water(solid∶liquid =1∶20). The static analysis insisted that activated zeolite had a significant adsorption for fluorine. The dynamic analysis verified that the fluoride level could reach the standard after 40 min of treatment. Regenerated with 2.0% KAl(SO4)2,the effect of removing fluoride was 45.0%. Conclusion The experiments testified that the processed natural zeolite can used in water treatment of high fluoride groundwater.