1.Investigation and Analysis of Physical and Mental Health of Nurses
Journal of China Medical University 2015;(12):1116-1119,1124
Objective to investigate the situation of occupational health of nurses,so as to provide a reference for protecting the health of nurses. Methods Cluster sampling method was employed in this study. totally 1 204 nurses of two three-level general hospital and a cancer hospital in Bei-jing were randomly surveyed with homemade health of nurses′cross-sectional questionnaire,and a nurse medical examination report was access at the same time. Results there was statistically significant difference in the incidence of nurses work pressure and work fatigue in different hospitals and different departments(P < 0.05). 95.18% of the nurses undergo regular medical examinations,of which 56.97% were found abnormal. the dif-ferences in the incidence rate of abnormal medical examination results in nurses were statistically significant among different hospital and different de-partments(P < 0.05). Conclusion Great job stress and work fatigue are observed in nurses,and they have health problems. It is necessary for the hospital to take appropriate interventions to improve physical and mental health nurses.
4.Difficulties in pathologic diagnosis of soft tissue tumors.
Chinese Journal of Pathology 2011;40(6):416-419
Adolescent
;
Adult
;
Breast Neoplasms
;
pathology
;
Carcinoma
;
pathology
;
Diagnosis, Differential
;
Endothelium, Vascular
;
pathology
;
Fasciitis
;
pathology
;
Female
;
Hemangiosarcoma
;
pathology
;
Histiocytoma, Malignant Fibrous
;
pathology
;
Humans
;
Hyperplasia
;
pathology
;
Leiomyoma
;
pathology
;
Leiomyosarcoma
;
pathology
;
Middle Aged
;
Soft Tissue Neoplasms
;
pathology
;
Uterine Neoplasms
;
pathology
;
Vascular Diseases
;
pathology
5.Therapeutic effect of r-SK on acute myocardial infarction: a report of 20 cases
Changyong BIAN ; Yongwen QIN ; Xing ZHENG
Academic Journal of Second Military Medical University 1999;0(12):-
Objective: To observe the therapeutic effect of intravenous thrombolysis of recombinant streptokinase (r SK) on acute myocardial infarction (AMI) and its safety. Methods: Twenty patients with AMI received r SK for thrombolysis.The reopening rate of infarct related artery,side effect and the fatality rate in hospital were observed. Results: The reopening rate of infarct related artery was 75%. The incidence of slight hemorrhage, fever, low blood pressure,which could be corrected in short time, was 5%, 15%, 15%, respectively. The fatality rate 5 weeks after AMI was 10%. Conclusion: The therapeutic effect of r SK in the thrombolytic therapy of AMI is definite and the safety is fine.
6.Neoplasms with perivascular epithelioid differentiation.
Chinese Journal of Pathology 2010;39(3):205-209
Carcinoma, Renal Cell
;
pathology
;
Diagnosis, Differential
;
Digestive System Neoplasms
;
pathology
;
Female
;
Gastrointestinal Stromal Tumors
;
pathology
;
Humans
;
Kidney Neoplasms
;
pathology
;
Leiomyoma
;
pathology
;
Male
;
Melanoma
;
pathology
;
Perivascular Epithelioid Cell Neoplasms
;
pathology
;
Sarcoma, Clear Cell
;
pathology
;
Sarcoma, Endometrial Stromal
;
pathology
;
Skin Neoplasms
;
pathology
;
Soft Tissue Neoplasms
;
pathology
;
Uterine Neoplasms
;
pathology
7.Myxoid soft tissue tumor of children.
Chinese Journal of Pathology 2013;42(3):208-211
Cell Differentiation
;
Child
;
Dermatofibrosarcoma
;
metabolism
;
pathology
;
Diagnosis, Differential
;
Humans
;
Immunohistochemistry
;
Infant
;
Lipoblastoma
;
metabolism
;
pathology
;
Liver Neoplasms
;
metabolism
;
pathology
;
Mesenchymoma
;
metabolism
;
pathology
;
Neoplasms, Germ Cell and Embryonal
;
metabolism
;
pathology
;
Sarcoma
;
metabolism
;
pathology
;
Skin Neoplasms
;
metabolism
;
pathology
;
Soft Tissue Neoplasms
;
metabolism
;
pathology
8.Self-blood therap for 62 cases of senile skin pruritus.
Hui XIAO ; Jian QIN ; You-Xing ZHANG
Chinese Acupuncture & Moxibustion 2013;33(8):757-758
Acupuncture Points
;
Aged
;
Aged, 80 and over
;
Bloodletting
;
Female
;
Humans
;
Middle Aged
;
Pruritus
;
therapy
9.Effect of T-1ymphocyte subset on lymph node micrometastasis in esophageal cancer patients
Zimin QIN ; Yin LI ; Wenqun XING
Clinical Medicine of China 2008;24(10):1055-1057
Objective To acknowledge the effect of T-lymphocyte subset on lymph node micrometastasis in esophageal cancer patients by the study of the correlation between T-lymphocyte subset and micrometastasis.Methods CD3+、CD4+、CD8+and CD4+/CD8+ were examined in esophageal cancer patients under thoracotomy by flow cytometry,and the micrometastasis were examined by immunohistochemistry in lymph node that were diagnosed as negative for metastases by routine histopathological analysis.Two groups were divided by with or without micro-metastasis,T-lymphocyte subset were compared with two groups.Results CD3+,CD4+ and CD4+/CD8+were significantly lower in group with micrometastasis than in group without micrometastasis,CD8+ was significantly higher in group with micrometagtasis than in group without micrometastasis.Conclusion T-lymphocyte subset is closely associmed with micrometastasis and low CD3+,CD4+ and high CD8+ T-lymphocyte is associated with poor cancer-specific survival.
10.CRMP2 alleviates neurological deficit by reducing neuron apoptosis in rats after cerebral ischemia/reperfusion injury
Xiangfeng XING ; Tianzhu WANG ; Xinyue QIN
Chinese Pharmacological Bulletin 2016;32(4):548-553
Aim To investigate the influence of the overexpression of CRMP2 on neural cell apoptosis after ischemia reperfusion injury in rats and its possible mechanism. Methods A total of 192 male adult SD rats were divided into four groups: sham group, cere-bral ischemia/reperfusion group( MCAO group) , cere-bral ischemia with blank plasmid control group( MCAO+GFP group ) , cerebral ischemia with CRMP2 eu-karyotic plasmid group ( MCAO + CRMP2/GFP group) . One day after injecting eukaryotic plasmid, the rats were operated for 120-min ischemia through MCA occlusion and reperfused. At 48 h and 1 wk, the expression of CRMP2 , p53 , Caspase-3 , Caspase-8 and BCL2 in brain tissue was tested by RT-PCR and West-ern blot. Apoptotic cells were observed by TUNEL test. TTC staining was use to detect cerebral infarction volume. The neural function of the rats were also eval-uated. Results Compared with the sham group, the expression levels of CRMP2 and BCL2 in MCAO group and MCAO +GFP group were significantly decreased ( P <0. 01 ) , while p53 , Caspase-3 , Caspase-8 and TUNEL positive cells were elevated(P<0. 01). Inter-vention of CRMP2 eukaryotic plasmid resulted in the increased expression of CRMP2 and BCL2 ( P<0. 01 ) and the decreased p53 , Caspase-3 and Caspase-8 ex-pression. In TUNEL test, overexpression of CRMP2 obviously decreased the number of TUNEL positive cells(P<0. 01). The expression of BDNF was upregu-lated after cerebral ischemic injury ( P<0. 01 ) , while overexpression of CRMP2 increased BDNF more signif-icantly ( P <0. 01 ) . TTC staining showed cerebral in-farction Volume of MCAO + CRMP2/GFP group was obviously decreased ( P <0. 01 ) , and neurologic defi-cits were significantly improved ( P <0. 01 ) . Conclu-sion The overexpression of CRMP2 reduces nerve cell apoptosis possibly by regulating the mitochondrial ap-optosis pathway after cerebral ischemia/reperfusion in-jury to protect nervous system.