1.Causes of fever in 26 patients after the surgery for congenital heart disease
Chinese Journal of Infection Control 2016;15(5):309-312,316
Objective To explore causes of fever in patients after the surgery for congenital heart disease(CHD), and put forward corresponding prevention and control measures.Methods Clinical data of patients undergoing sur-gery for CHD in the department of pediatric surgery of a hospital between January and May 2013 were analyzed ret-rospectively,the whole process of operation and postoperative nursing were observed,environmental hygiene moni-toring was performed at the same time.Results 26 patients all had fever after operation,fever in 21 cases (80.77%)was caused by non-infectious factors,5(19.23%)by infectious factors (ventilator-associated pneumonia in 4 cases,type I incision infection in 1 case).6 cases were absorption fever,20 were abnormal fever,difference in patients’age,duration of invasive manipulation (ventilator,urinary catheter,gastric tube)between two groups of patients were all statistically significant (all P <0.05),patients in the absorption fever group were with older age and short invasive manipulation time.Bacteriological detection rate in 26 patients was 76.92% (n=20),a total of 58 specimens were detected,7 were positive (from sputum specimens of 4 patients),5 isolates (71 .43%)were Pseudomonas aeruginosa .A total of 52 environmental specimens were collected for detection,the qualified rate was 80.77% (n =42).Conclusion Non-infectious factors are the main causes of postoperative fever in patients with CHD,health care workers should enhance the awareness of sterilization,standardize all kinds of medical manipula-tion,and reduce postoperative fever.
2.Biocompatibility of intraocular lens cytokine in aqueous humor
International Eye Science 2014;(11):1982-1986
Intraocular lens ( IOL) implantation is the major method to replace the cataract lens. How to improve the biocompatibility of IOL has been the focus of current research. Major reactions after the IOL implantation include endophthalmitis, corneal endothelial edema, iritis, uveitis, and posterior capsule opacification, etc. At cellular level, macrophages, monocytes, fibroblasts and lens epithelial cells can be detected on the surface of IOL. Their adhesion, proliferation migration, and transformation may be induced by the operation related cytokines released into the aqueous humor. Detailed analysis of cytokines profile after IOL implantation may be beneficial to explore the mechanism of posterior capsule opacification.
4.Therapeutic effects of hypobaric hypoxia on asthma in guinea pigs
Xiangying KONG ; Qin GUI ; Jiasi BAI
Chinese Journal of Pathophysiology 2001;17(6):550-552
AIM: To explore the mechanism of the therapeutic effect of hypobaric hypoxia on allergic asthmas guinea pigs. METHODS:After the model of asthma was established with ovalbumin(OA) challenge in OA sensitized guinea pigs, the animals were randomized into the asthmas group(AG), the alleviative group(ALG) and hypobaric hypoxia treated group(HHTG). The levels of plasma cortisol and endothelin(ET), ET in bronchoalveolar lavage fluid(BALF) were determined by radioimmunoassay. The pulmonary pathological changes were observed with optical microscope. RESULTS:(1) Infiltration of eosinophils (EOS) in alveolar septum was found in AG and ALG, while it was reduced in HHTG. (2) The level of plasma cortisol was significantly higher in AG than in normal control group(NCG) (P<0.01).But it was significantly lower in ALG than in NCG(P<0.01), there was no difference in plasma cortisol level between HHTG and NCG. (3) The content of ET in plasma was significantly higher in ALG than that in NCG, AG and HHTG(P<0.01), and ET level in BALF was significantly higher in AG than that in NCG, ALG and HHTG(P<0.05),however, no significant difference was found among the latter three groups, respectively. CONCLUSION: After the treatment with hypobaric hypoxia, the ET levels of the plasma and BALF were decreaced and the content of plasma cortisol was increaced, and infiltration of EOS in alveolar septum was decreaced in asthmatic guinea pigs.That may be one of the mechanisms by which hypobavic hypoxia prevents and cures asthma.
5.Linkage disequilibrium of microsatellite markers on chromosome 6 and its relationship with asthma
Qin GUI ; Guisheng QIAN ; Guijun HUANG ;
Journal of Third Military Medical University 2003;0(14):-
Objective To explore the relationship between the microsatellite markers on chromosome 6 and the phenotypes of atopy. Methods Sixteen microsatellite markers on chromosome 6 were evaluated in 20 affected sib pair and trios families. Linkage disequilibrium analysis was conducted according to asthmatic phenotypes (total IgE, skin prick test, bronchial hyper responsiveness and eosinophil) by ETDT software system. Results Significant P value( P
6.On Strengthening Academic Administration in Departments and Improving Quality of Higher Education
Lei HUANG ; Chizi QIN ; Chengjun GUI
Chinese Journal of Medical Education Research 2003;0(02):-
The fulfillment of the university's macro-policy lies in the teaching management at the departmental level, so it is essential to examine the status quo of departmental management and seek its rationalization and standardization. To restructure the managerial system, to bring to full play the academic management and to improve managers' competence prove to be the effective ways for enhancing the teaching management at the departmental level and the quality of education.