Object ive To find related risk factors after PEIT under ultrasound .Methods We collected the data of 73 clinical PEIT cases from January 2007 to December 2011 .Univariate analysis found the related risk factors of PEIT.Multivariate analysis identified the independent risk factors .Results Single factor analysis showed that the differences between groups of patient′s sex,age,the positive and negative of serum HBsAg ,tumor location,tumor number in survival rates were not statistically significant;the differences in groups of tumor size , serum AFP levels,with or without portal vein tumor thrombus ,liver function(Child)grade,tumor type in survival rates were significant differences .Multivariate and stepwise regression analysis showed that liver function ( Child) grade,tumor type,tumor metastasis,portal vein thrombosis were factors relevant to prognosis ;all chi-square test,χ2=47.763,P<0.01;likelihood ratio test χ2=450.546 ,P<0.01.Conclusion liver function ( Child-pugh grade),pathological type of tumors,tumor′s metastasis,emboli in portal vein are the risk factors after PEIT .

Pulmonary arterial hypertension is one of the most common and serious complications in congenital heart disease.Identification of whether the pulmonary arterial hypertension is dynamic or resistance remains as the great importance for deciding to transfer for surgery,intervention or conservative therapy and directly concerning with the prognosis and choice of treatment.This review mainly deals with the problems such as grading,staging,pathophysiology and the correlative mechanism with clinical assessment of pulmonary arterial hypertension in congenital heart disease and furthermore providing comprehensive informations for clinical diagnosis and treatment.

Objective To compare the rDNA-ITS differentiation and its regulation between Morinda (officinalis) and its counterfeit species, and provide DNA molecular markers for the fingerprint identification of them. Methods The rDNA-ITS regions of M. officinalis and its counterfeit species were amplified and sequenced, then analyzed by means of CLUSTRAL X and MEGA softwares. Results The internal transcribed spacers (ITS) including ITS1, 5.8S, ITS2, and partial 18S and 26S were determined. In DNA DIST analysis, the range of diversity among M. officinalis and M. shughuaeusis, M. umbellata was (2.9%-)5.8% and 2.9%-4.2% based on ITS1 and ITS2; the range of diversity between M. officinalis and Damnacanthus indicus was 21.2% and 18.9% based on ITS1 and ITS2. Phylogenetic tree based on ITS and 5.8S sequence data indicated the M. umbellata and M. shuanghuaensis were closely related then with M. officinalis, while D. indicus was monophyletic group. Conclusion The rDNA-ITS sequence is a better molecular marker for idertification of M. officinalis and its counterfeit species.

[Objective] To summarize the experience of Professor ZHANG Qin, a famous Chinese doctor in Zhejiang Province, in the treatment of dysmenorrhea by clinical syndrome differentiation. [Methods] Through the examples of teacher ZHANG's clinical treatment of primary dysmenorrhea and secondary dysmenorrhea in three cases, combined with the usual clinical experience of Professor ZHANG Qin to follow, analyze and summarize teacher ZHANG's clinical experience of the treatment of dysmenorrhea. [Results] Three cases show that, whether it is the primary dysmenorrhea or secondary dysmenorrhea, ZHANG believes that the total incidence of cold stagnation of Qi, blood circulation is not smooth, the main reason for the lack of collateral. A sense of cold dampness to menstrual wading, passengers in the cytoplasm, with warm and cold, blood, Tiaochong;with blood stasis, expelling, warming channels to dispel cold, removing blood stasis and relieving pain; also, liver blood deficiency and blood stasis of uterus, cure properly via removing film, streteving liver and removing stasis to relieve pain. Along with symptoms, with mild blood for treatment, in order to reconcile Qi and blood, Chongren unblocked. [Conclusion] Professor ZHANG Qin's experience in the treatment of dysmenorrhea by clinical syndrome differentiation has distinctive features and positive effects, so it is worth in-depth study and application.

Objective And effect of psychological intervention observation and analysis of iron combined with erythropoietin in the treatment of anemia in hemodialysis patients and the effect of. Methods 110 cases of Shaoxing Hospital of Traditional Chinese Medicine in anemic hemodialysis patients with January 2015 to February 2016 underwent diagnosis and treatment as the research object of the study, all the patients were randomly divided into 2 groups, respectively for the test group and control group, 2 groups of 55 cases. The control group was treated with erythropoietin receptor activator and psychological intervention treatment, experimental group was treated with ferrous succinate combined with erythropoietin receptor activator for treatment, but also psychological nursing intervention, observation and comparison of the symptoms of anemia, 2 groups of patients after treatment of adverse reaction etc. Results The experimental group patients with red blood cells, serum ferritin, hemoglobin and hematocrit were significantly higher than control group, the difference was statistically significant (P<0.05); side effects in test group than in the control group, the difference was statistically significant (P<0.05). Conclusion Iron combined with erythropoietin treatment in anemic hemodialysis was more effective at the same time, then the implementation of the corresponding psychological intervention, can reduce the adverse reactions in patients with symptoms, improve the safety of the treatment, and has high applicationvalue.

Objectiv To explore the effects of chromium (Ⅵ) on the levels of malondialdehyde (MDA), the final product of lipid peroxidation in peripheral blood of mice and the micronucleus rate of polychromatic erythrocytes (PCE) in peripheral blood. Method 60 Kunming mice were divided randomly into 6 groups averagely. 4 groups were selected as exposure groups which were exposed to 10.27, 13.83, 20.74, 41.48 mg/kg calcium chromate by oral perfusion, one time per day, for 6 days. The negative and positive control group was exposed to distilled water and cyclophos phamide (40 mg/kg) respectively. After exposure, the levels of MDA and micronucleus rates of PCE were determined. Results Significant increases of the levels of MDA and the micronucleus rates of PCE in peripheral blood of mice were observed, which were associated with the increases of the exposure doses of chromium (Ⅵ). Significant positive correlation was observed between the micronucleus rates of PCEs (x) and MDA(nmol/ml) levels (y) in peripheral blood (y=3.705+930x,r=0.958, P

In the process of responding to public health emergencies,the conflicts between the principles of management and ethics are constantly revealed.Combining with a unit's practical experiences of participating in several major public health emergencies,this paper put forward that it should take into account both the rescue and notification to achieve the unity of effective rescue and informed consent;take into account both the enforcement and obedience to achieve the unity of the interest of groups and individuals;take into account both the equality and priority to achieve the unity of urgency priority and equal opportunity;take into account both the rescuing and suf-fering to achieve the unity of interest between the rescuers and the victims,and thus to provide references for the reasonable solution of the ethical conflicts in the process of responding to public health emergencies.

Objective To determine the accuracy and radiation dose of dual-energy computed tomography (CT) in evaluating solitary pulmonary nodules (SPNs) by virtual non-enhanced images.MethodsSixty-one patients with SPNs including 39 malignant and 18 benign nodules proved by pathology underwent DECT scans. The CT values of SPNs on enhanced weighted average and virtual non-enhanced images were compared by using Liver VNC processing unit in terms of their diagnostic accuracy for distinguishing malignant and benign nodules with a 20 HU threshold. Diagnostic accuracy was compared. In 28 patients of all patients, image noise and quality score of the non-enhanced and virtual non-enhanced images were compared, and radiation doses of each patient were recorded. The paired t test was used to analyze the noise difference between the plain scan and virtual non-enhanced scan. The Mann-Whitney U test was used to analyze statistically significant differences of the image quality score and radiation dose between the non-enhanced scan and virtual non-enhanced scan. ResultsThe sensitivity, specificity and accuracy for distinguishing benign and malignant nodules by using the virtual non-enhanced image of were 89. 7％(35/39), 72.2％ (13/18), 84.2％ (48/57)respectively.The noise of common CT and virtual nonenhanced images were(8. 49 ± 1. 94) HU and( 10. 14 ± 2. 18 ) HU, and there were statistically difference (t＝9.45,P＜0. 01 ). The quality scores of common CT and virtual non-enhanced images were (4.71 ±0. 46 ) and ( 4.42 ± 0. 57 ), and there were no statistical difference ( U ＝ 290. 00, P ＞ 0. 05 ). The radiation doses of common CT and DECT were ( 3. 72 ± 0. 48 ) mSv and ( 3.78 ± 0. 45 ) mSv, and there were no statistical difference ( U ＝ 350. 50,P ＞ 0. 05 ). ConclusionDECT by using virtual non-enhanced images is useful tool to distinguish the benign and malignant SPN without additional radiation dose.

Heart Valve Diseases ; therapy ; Heart Valve Prosthesis Implantation ; methods ; Humans

ADAMs is a family of transmembrane proteins with multi domains and multiple functions,which play important roles in many(patho-)physiological processes.They are upregulated in a variety of tumors and possess protein shedding and adhesive activities,which showed that they could be useful as tumor biomarkers and promising targets for designing new anti-tumor drugs.This review focuses on the roles ADAMs play in the process of tumor development and the potential application in cancer therapy.