Parents and family background cast important influence on children's attachment style. Studies have consistently showed positive relations between maternal sensitivity and infant attachment security. Warm and harmonious family was also found to be an important factor. On the contrary, parents' poor marital status and high level of stress in family would result in insecure attachment style in children.

Magnetic resonance imaging (MRI),a commonly used imaging technique,has been extensively investigated in lung cancer diagnosis and staging.Many studies have demonstrated that MRI can be used for the differential diagnosis of benign and malignant pulmonary nodules and for the screening of lung cancer; it also has important value in TNM staging of non-small cell lung cancer (NSCLC),with equivalent sensitivity and specificity to 18F-fluorodeoxyglucose (18F-FDG) PET-CT,which suggests that MRI can be used as an alternative imaging modality in noninvasive diagnosis and staging of NSCLC.

The knowledge atlas for researches of invisible knowledge management was plotted after the key words and their relationship in papers on invisible knowledge published in the past 5 years were quantitatively and qualitatively analyzed by social network analysis, co-words cluster analysis, and impact factor analysis with the journal articles covered in CNKI, Wanfang, VIP Chinese Scientific and Technological Journals Databases as the data source.The hotspots and structure in researches of invisible knowledge management were then studied in order to provide reference for the innovative development and future research of invisible knowledge management.

Objective To investigate the status of professional identity of Xinjiang nursing students and analysis on the differences in different nations and educational levels, so as to provide the basis for nursing professional identity education. Methods By cluster sampling,a total of 626 nursing students of two schools in Xinjiang were surveyed by general information questionnaire and the Professional Identification Scale for nursing students. Results Theprofessional identity level of Xinjiang nursingstudents was in the medium level scored 62.13 ± 12.54. The highest level was Uighur nursing students scored 67.76 ± 10.9, followed by other national nursing studentsscored 59.44 ± 12.99, the lowest level was Han national nursing studentsscored 56.41 ± 11.25 (F=69.654, P<0.05). The highest level of professional identity was secondary school studentsscored 66.71 ± 10.96, followed by junior college studentsscored 59.33 ± 8.23, the lowest level was undergraduate studentsscored 57.32 ± 12.54 (F=49.815, P < 0.05). Conclusions The professional identity of nursing students is not high,and were affected by many factors. It is suggested that nursing educational workers should take various measures to implement nursing students professional emotional education. Nursing teachers should possess higher level of professional identity,and guide students to set up the correct professional identity in various angles.

For children suffering from primary nephrotic syndrome(PNS), podocyte is a crucial part of glomerular filtration barrier, whose injury usually causes proteinuria.The structural and functional integrity of podocyte cytoskeleton is the prerequisite of its normal physiological function.Recent studies demonstrated that under a certain pathological condition, B7-1, expressed in podocyte, can inhibit the activation of β1 integrin by competitively binding to the target site on the β1 integration, which may change the morphology and function of podocyte, consequently induced proteinuria.Other studies also have showed that abatacept, which selectively inhibit the cross-talk between B7-1 and β1-integrin,can reduce proteinuria in patients with B7-1-positive glomerular disease.These studies suggested that B7-1 may be a potential diagnostic biomarker and therapeutic target in proteinuria in PNS.This review summarizes the role of B7-1 expressed in podocyte in the pathogenesis of proteinuria and the possibility of clinical application in the future.

Objective To investigate the distribution of pathogens in elderly patients with bronchiectasis and drug resistance.Methods Elderly hospital patients with bronchiectasis were selected,pathogens isolated from sputum specimens and analysis of bacterial resistance.Results 221 strain of pathogen were isolated,of gram -positive bacte-ria 57 strain(25.79%),gram -negative bacteria 151 strain(68.32%);gram -negative bacteria Pseudomonas aerug-inosa pneumonia Klebsiella,Acinetobacter baumannii and Escherichia coli -based was 20.36%,14.02%,15.84%and 9.05% respectively;gram -negative bacteria Staphylococcus aureus,Staphylococcus epidermidis and Streptococ-cus pneumoniae based was 9.50%,8.60% and 7.69% respectively;other fungi,the proportion was 5.88%. Conclusion Elderly patients with bronchiectasis distribution of pathogens to the highest proportion of gram -negative bacteria,including Pseudomonas aeruginosa in the first row,tip rational use of antimicrobial drugs in reducing the rate of drug resistance plays an important role.

Objective To analyze the fetal growth ,development and birth situation in umbilical artery absent end‐diastolic flow(AEDF) in late pregnancy .Methods The umbilical artery blood flow signals were detected by color ultrasonic diagnostic in‐strument .The fetal growth indexes and Apgar score at birth were compared between the normal umbilical artery group and the AEDF group .Results The occurrence rate of fetal growth and development less than the gestational age was significantly higher than that in the normal group ,moreover the occurrence rate of intrauterine stress was also obviously higher than that of the normal group .Conclusion Umbilical arterial AEDF in late pregnancy prompts the fetal intrauterine hypoxia and relatively slowly fetal grow th .

After a description of the differences between formative evaluation and summative evaluation, the appli-cation of formative evaluation in literature retrieval course evaluation in medical colleges and universities was elabo-rated by analyzing the current situation of literature retrieval course and its evaluation in medical colleges and uni-versities with Xinjiang Medical University as an example, which showed that the principles should be followed when formative evaluation is applied in literature retrieval course evaluation.The problems related with the application of formative evaluation in literature retrieval course evaluation were pointed out.

BACKGROUND:Extracelular matrix degradation and remodeling is the common pathway of a variety of pathological and physiological processes, and is invovled in the pathogenesis of a variety of oral diseases. OBJECTIVE: To analyze the role of extracelular matrix remodeling folowing celular apoptosis in recurrent aphthous ulcer and the therapeutic effect of baicalin, so as to provide references for new drug development and clinical treatment. METHODS: Forty Sprague-Dawley rats were randomly divided into four groups: control, recurrent aphthous ulcer model, low-dose baicalin and high-dose baicalin groups. Rat models were established using oral mucosal homogenate plus Freund’s immunoadjuvants in the recurrent aphthous ulcer model, low-dose baicalin, and high-dose baicalin groups. Rats in low-dose baicalin and high-dose baicalin groups were intragastricaly administered 10 mg/kg and 100 mg/kg of baicalin respectively for 14 days, once per day. RESULTS AND CONCLUSION:Compared with the control group, serum superoxide dismutase level was distinctly decreased, however, malondialdehyde level distinctly increased; the expression levels of Bax, Caspase3 and matrix metaloproteinase 2/9 were increased, but the expression of Bcl2 was decreased in the recurrent aphthous ulcer model group. The abovementioned indicators of rats returned greatly towards normal levels in the low dose baicalin and high dose baicalin groups, and there was significant difference in the effects of different doses of baicalin on these indicators. These results suggest that baicalin treats recurrent aphthous ulcer mainly through inhibiting extracelular matrix degradation and remodeling.

Objective To identify the genotype and allele distribution feature of cytochrome CYP2C19 in Chinese Uighur , Kazak and Han populations ,and by detecting the CYP2C19 genotype .Methods Finding out the differences of genotype distribution among the three Chinese nationalities .The 750 inpatients were selected from Second Department of Internal Medicine ,Cadres Ward of First Affiliated Hospital of Xinjiang Medical University .The CYP2C19 genotypes of the unrelated patients were assessed by pol‐ymerase chain reaction and restriction fragment length polymorphism .Results Six different CYP2C19 genotypes were determined in this study .There was a significant difference among the three Chinese nationalities (P< 0 .05) .The rate of fast metabolism type in Kazak is 93 .8% more than the rate of Han populations .The rate of slow metabolism type in Kazak is 6 .2% less than the rate of Han populations .The difference was statistically significant (P= 0 .006) .Conclusion Nationality has significant effect on genetic polymorphism of CYP2C19 in Chinese Uighur ,Kazakand and Han populations .