Objective Funded papers on pituitary adenoma were bibliometrie analyzed to provide fund information on pituitary adenoma for the researchers.Methods Funded papers on pituitary adenoma from 1994 to 2007 were searched by strategy using pituitary adenoma and fund as key words in Chinese Medical Current Contents.Evaluation of papers on quantity of papers,fund type,level and proportion,the first atuhor,journal,distrier and institute by bibliometries method.Results In 1629 papers collected,there are 110 funded papers,which are comprised of 70 papers supported by National funds(49 supported by National Natural Science Foundation),40 funded by provincial funds.In these papers,there are 65 on basic research(8 on neuropeptide),45 on clinical research(9 on surgery) and 11 are dual funds supported.Of these papers,the first author,journal published on,work institute and distiet,in proper order to Zhang Xiang(7 papers),Chinese Journal of Neurosurgical Disease Research(13 papers),the fourth military university(18 papers) and Shanxi(16 papers).Conclusions The analysis summarizes 49 subjects of National Natural Science Foundation,11 subjects supported by dual funds,core authors and core journals of these papers,which are of great help for researchers' research works.

Objective To investigate the efficacy of pantoprazole and omeprazole in the prevention of postoperative stress ulcer.MethodsThe patients were divided into control group (pantoprazole) and observation group (omeprazole) according to the random number table method from December 2015 to December 2016 in 200 cases of abdominal surgery.The incidence and adverse effects of stress ulcer were measured and the cost and effect were calculated.ResultsIn the observation group, the incidence of stress ulcer was 4.0% (4/100) in the observation group compared with 5.0% (5/100) in the control group(χ2=0.11, P=0.73).Compared with the control group, Both groups were treated with liver and kidney function and blood routine examination, no obvious abnormalities, and no significant adverse reactions during treatment.ConclusionAbdominal surgery patients with pantoprazole and omeprazole can effectively prevent postoperative stress ulcers, the cost of no significant difference, no significant adverse reactions.

This article aims to study the present condition and disadvantages of current obstetrics and gynecology teaching and discuss the urgent needs and methods of evidence-based medicine (EBM) introduction to it.

Objective To study the expression of interleukin-17 (IL-17) in diabetic rat aorta and the effect of intervention with resveratrol,meanwhile,to explore the potential mechanisms of IL-17 induced diabetic vascular diseases and the protective role played by resveratrol in the epigenetic field.Methods The experiment was carried out in 4 groups:normal control group(NC),normal interventional group(NB),diabetic group(DM),and diabetic interventional group(DB),NB and DB groups were intervened with resveratrol.Immunohistochemistry was used to observe the histological localization of IL-17 and to measure the thickness of rat abdominal aorta.Western blotting,real-time PCR,and methylation-specific PCR were used respectively to compare the expression of IL-17 protein and mRNA,as well as DNA methylation in 4 groups.Results IL-17 mainly expressed in arterial intima of diabetic rats,the abdominal aorta in DM group was obviously thicker than that in NC and DB groups(P＜0.05).IL-17 protein and mRNA expressions in DM group were significantly higher than NC group(P＜0.05),and were reduced in NB and DB groups compared with NC and DM groups respectively.While DNA methylation levels of IL-17 in DM group were significantly lower than NC group(P＜0.01),however,the levels in NB and DB groups were elevated accordingly as compared with corresponding groups.Conclusions The increased levels of IL-17 in aorta of diabetic rats suggests that IL-17 is involved in the process of inflammatory responses to diabetic macrovascular diseases,while resveratrol could inhibit the expression,it may play a role in protecting aorta,and the regulation of IL-17 gene promoter DNA methylation levels may be the potential mechanism underlying these two phenomena.

Cholesteatoma ; diagnosis ; pathology ; Humans ; Petrous Bone ; pathology

Objective To analyze the cause and therapeutic effect of acute intestinal obstruction of different age groups in metropolitan. Method The data of 165 cases of acute intestinal obstruction admitted in our department from January 1995 to December 1999 were analyzed retrospectively. Patients over 60 belonged to aged group and the ones below 60 belonged to adult group. Results Among 165 cases, 98 cases belonged to the aged group while 67 belonged to the adult group. There were 68 cases of colorectal cancer, 45 cases of adhesion, 13 cases of cancer metastasis, 10 cases of volvulus of sigmoid colon, 7 cases of oblique hernia and 22 cases of other causes. Cancer was the main cause in the aged group (44.9%, 44/98) and adult group (55.2%, 37/67) (P＞0.05) . Adhesion accounted for 30. 6% (30/98) and 22.4% (15/67) in these two groups. 79.5% of the patients with colorectal cancer in the aged group and 94.6% in the adult group recieved operation(P＜0.05) . The resection rate of colorectal cancer was almost the same between the two groups. The mortality was 7.1% (7/98) in the aged group and 2.9% (2/67) in the adult group respectively(P＜0.05) . Conclusions Tumor is the main cause of acute intestinal obstruction in metropolitan followed by adhesion. The mortality is significantly high in aged group.

Objective To analyze the cause and therapeutic effect of acute intestinal obstruction of different age groups in metropolitan. Method The data of 165 cases of acute intestinal obstruction admitted in our department from January 1995 to December 1999 were analyzed retrospectively. Patients over 60 belonged to aged group and the ones below 60 belonged to adult group. Results Among 165 cases, 98 cases belonged to the aged group while 67 belonged to the adult group. There were 68 cases of colorectal cancer, 45 cases of adhesion, 13 cases of cancer metastasis, 10 cases of volvulus of sigmoid colon, 7 cases of oblique hernia and 22 cases of other causes. Cancer was the main cause in the aged group (44.9%, 44/98) and adult group (55.2%, 37/67) (P＞0.05) . Adhesion accounted for 30. 6% (30/98) and 22.4% (15/67) in these two groups. 79.5% of the patients with colorectal cancer in the aged group and 94.6% in the adult group recieved operation(P＜0.05) . The resection rate of colorectal cancer was almost the same between the two groups. The mortality was 7.1% (7/98) in the aged group and 2.9% (2/67) in the adult group respectively(P＜0.05) . Conclusions Tumor is the main cause of acute intestinal obstruction in metropolitan followed by adhesion. The mortality is significantly high in aged group.

ObjectTo study the effect of polydatin (PD) and asymmetric dimethylarginine (ADMA) on the endothelial function in aorta vascular strips of healthy rabbits and the interaction between PD and ADMA. MethodsDose-response curves of phenylephrine (PE) on the aortic strips with or without ADMA and/or PD. E max and Kd from PE were obtained and compared. ResultsNormal aortic strips could not respond to ADMA. Pretreatment with either PD or ADMA had no effect on the contractive response of aortic strips to PE. But PD could significantly weaken the contractive response of aortic strips pretreated with ADMA caused by PE in a dose-dependent manner, increase Kd and decrease E max of PE. ConclusionEither ADMA or PD alone does not influence the normal aortic strip contractive functions, the PE affinity to ?-receptor, and E max. But PD could noncompetitively antagonize the contractive reaction of aortic strips to PE in the presence of ADMA.

The information-knowledge-intelligence transformation rules were introduced as the theory for the transformation of information service main body for evidence-based medicine according to the analysis of domestic and foreign institutional main body and personal main body for the information service of evidence-based medicine.It was proposed that medical library as the institutional main body should be transformed into information repository + thinking library and clinical medical librarians as the personal main body should be transformed into evidence witness + decision making adviser with associated literacy.

Objective To establish a method for rapidly detecting the G-protein ?3 subunit (GNB3) 825 site single nucleotide polymorphism (SNP) and to analyse the relationship between GNB3 825 site gene SNP and obesity. Methods The real-time fluorescent PCR was employed to analyse the GNB3 825 site gene SNP of 420 samples from 21 provinces and the the frequencies of genotypes were compared with those detected by gene sequencing. GNB3 825 site genotype, body weight, body mass index (BMI) and fat content were examined from 207 subjects and the correlation between GNB3 825 site gene SNP and obesity was analysed. Results The result by real-time fluorescent PCR showed that the frequencies of 825T and 825C haploid were 46.90% and 53.10%, respectively, and the frequencies of 825TT, 825TC and 825CC genotype were 22.38%, 51.42% and 28.10%, respectively, with no other genotype detected, which was consistent with the result by gene sequencing. BMI and fat content were significantly higher in subjects with GNB3 825TT than in subjects with other genotypes. Body weight was much higher in subjects with GNB3 825TT genotype than in subjects with 825CC genotype, but not significantly different with 825CT genotype. Conclusion A new rapid method for the detection of GNB3 825 site SNP has been successfully established. There existed significant correlation between GNB3 825TT genotype and obesity.