1.Generation of differentiated osteoblast specific fgfr1 knockout mice
Fubing LI ; Ling ZHAO ; Xiumin LU ; Ying YU ; Qifen HE ; Maomao CHEN ; Yaqi DUAN ; Huabing QI ; Lin CHEN
Journal of Third Military Medical University 1983;0(04):-
Objective To obtain differentiated osteoblast-specific inactivation of fgfr1 mice Methods To obtain fgfr1△/+/OC-CreTG/+ mice,fgfr1flox/flox mice obtained from NIH were crossed with OC-Cre mice To obtain fgfr1△/△/OC-CreTG/+ mutant mice,fgfr1△/+/OC-CreTG/+ further crossed with themselves or fgfr1flox/flox mice After fgfr1△/△/OC-CreTG/+ crossed with fgfr1flox/flox mice,half of their offspring were mutant mice Results Differentiated osteoblast-specific fgfr1 knockout mice were obtained Conclusion fgfr1△/△/OC-CreTG/+ mice were obtained through proper crossing strategy,which provides a suitable platform for studying fgfr1 function in bone development and fracture healing
Result Analysis
Print
Save
E-mail