1.Determination of the Content of Glycols in Chloramphenicol Eye Drops With HPLC Method
China Pharmacy 2001;12(5):301-
OBJECTIVE: To establish a method for detecting glycols in chloramphenicol eye drops METHODS: HPLC method was used with C18 column as stationary phase and methanol- 0 4% phosphoric acid( 55∶ 45) as mobile phase The detection wavelength was 245nm RESULTS: The average recovery was 98 5% ( RSD=0 86% ) CONCLUSION: The method is simple, reliable and suitable for detecting glycols in chloramphenicol eye drops
2.Hospitalization Due to Asthma Exacerbation: A China Asthma Research Network (CARN) Retrospective Study in 29 Provinces Across Mainland China
Jiangtao LIN ; Bin XING ; Huaping TANG ; Lan YANG ; Yadong YUAN ; Yuhai GU ; Ping CHEN ; Xiaoju LIU ; Jie ZHANG ; Huiguo LIU ; Changzheng WANG ; Wei ZHOU ; Dejun SUN ; Yiqiang CHEN ; Zhuochang CHEN ; Mao HUANG ; Qichang LIN ; Chengping HU ; Xiaohong YANG ; Jianmin HUO ; Xianwei YE ; Xin ZHOU ; Ping JIANG ; Wei ZHANG ; Yijiang HUANG ; Luming DAI ; Rongyu LIU ; Shaoxi CAI ; Jianying XU ; Jianying ZHOU ;
Allergy, Asthma & Immunology Research 2020;12(3):485-495
PURPOSE: Details of patients hospitalized for asthma exacerbation in mainland China are lacking. To improve disease control and reduce economic burden, a large sample survey among this patient population is indispensable. This study aimed to investigate the clinical characteristics and outcomes of such patients.METHODS: A retrospective study was conducted on patients hospitalized for asthma exacerbation in 29 hospitals of 29 regions in mainland China during the period 2013 to 2014. Demographic features, pre-admission conditions, exacerbation details, and outcomes were summarized. Risk factors for exacerbation severity were analyzed.RESULTS: There were 3,240 asthmatic patients included in this study (57.7% females, 42.3% males). Only 28.0% used daily controller medications; 1,287 (39.7%) patients were not currently on inhaled corticosteroids. Acute upper airway infection was the most common trigger of exacerbation (42.3%). Patients with severe to life-threatening exacerbation tended to have a longer disease course, a smoking history, and had comorbidities such as hypertension, chronic obstructive pulmonary disease (COPD), and food allergy. The multivariate analysis showed that smoking history, comorbidities of hypertension, COPD, and food allergy were independent risk factors for more severe exacerbation. The number of patients hospitalized for asthma exacerbation varied with seasons, peaking in March and September. Eight patients died during the study period (mortality 0.25%).CONCLUSIONS: Despite enhanced education on asthma self-management in China during recent years, few patients were using daily controller medications before the onset of their exacerbation, indicating that more educational efforts and considerations are needed. The findings of this study may improve our understanding of hospital admission for asthma exacerbation in mainland China and provide evidence for decision-making.
Adrenal Cortex Hormones
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Asthma
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China
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Comorbidity
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Disease Progression
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Education
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Female
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Food Hypersensitivity
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Hospitalization
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Humans
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Hypertension
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Inpatients
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Medication Adherence
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Mortality
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Multivariate Analysis
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Pulmonary Disease, Chronic Obstructive
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Retrospective Studies
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Risk Factors
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Seasons
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Self Care
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Smoke
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Smoking