OBJECTIVE To investigate the quantity of antibiotics prescribed yearly from 2001 to 2006 and the resistance of Enterobacter cloacae,and analyze the correlation between them.METHODS Its susceptibility to antimicrobial agents was performed by disk diffusion method and analyzed by WHONET 5.3.The correlation between DDDs and the resistance was analyzed using statistics.RESULTS The percentage of resistance of E.cloacae to the five drugs was decreased during recent six years.The most of decreased tendency was amikacin,its resistance in 2006 decreased 28% than that in 2001.The consumption of five drugs all decreased.The consumption of ceftazidime in 2006 was 1/12 compared in the 2004.The consumption of ciprofloxacin in 2006 was 1/8 compared in 2001.The analysis revealed a significant positive correlation between the resistance and DDDs of amikacin(r=0.8826,P

OBJECTIVE To determine the rationality of application of antibiotic prophylaxis in perioperative period in Department of Orthopedics in order to find evidence for clinical proper practice.METHODS A total of 150 patients with perioperative administration of antibiotics were included for the clinical analysis of rationality use of the drugs.RESULTS All of the 150 patients were given antibiotics in the perioperative period.All together 26 kinds of drugs belonged to 8 categories were used.Only 4% of the patients started antibiotic administration 2 hours just before operation,while 88% were