Objective To explore influence of comfort care on life quality of breast cancer patients undergoing chemotherapy. Methods Hospitalized breast cancer patients(80 eases) after modified radical mastectomy were selected by convenience sampling method.They were randomly divided into the intervention group and the control group.The control group received conventional care.The intervention group was given comfort care based upon conventional care.The quality of life questionnaire-core 30 (QLQ-C30) by European organization for research and treatment of eancer(EORTC),hospital anxiety and depression scale (HADS) and self-designed questionnaire of satisfaction degree with nursing job were adopted for evaluation of the two groups. Results There was no significant difference in the life quality of patients between two groups before intervention (P＞0.05),but statistical difference was seen after intervention (P＜0.05).The incidence rate of depression and anxiety after the intervention in the intervention group was significantly lower than that of the control group (P＜0.05) and the satisfaction degree with nursing job was significantly higher (P＜0.05). Conclusions Comfort nursing intervention can improve the quality of nursing service,reduce anxiety and depression,improve the life quality of patients.

Objective To investigate the status of patient safety culture cognition and safety nursing behavior among nurses and examine the influence of patient safety culture cognition on safety nursing behavior of nurses using structural equation model. Methods A total of 350 clinical nurses were recruited in a hospital in Dalian with multi-stage sampling method. Patient Safety Culture Assessing Scale, Safety Behavior Scale were delivered to the investigation object. Results The mean score of the patients safety culture was 4.09±0.47, which was above average;the total score of nurses′safety nursing behavior was 4.74 ± 0.31, which was at high level; the causality model of patient safety culture cognition and the safety nursing behavior was accepted (path coefficient=0.35,P<0.01). Conclusions Nurses′ patient safety culture cognition has a significant impact on safety nursing behavior. Hospital should cultivate the awareness of the patient safety culture, so as to promote the safety nursing behavior.

Objective To explore the application of lentil lectin‐reactive alpha‐fetoprotein ratio (AFP‐L3% ) applied in the dif‐ferential diagnosis between hepatitis B infection of primary liver cancer and benign liver disease .Methods We included 108 cases of chronic HBV infection ,including 50 cases of primary liver cancer ,42 cases of cirrhosis ,16 cases of chronic hepatitis .Chemilumines‐cence detection was used to detect alpha‐fetoprotein (AFP) and AFP‐L3 content ,AFP‐L3 and the ratio of AFP (AFP‐L3% ) was calculated .Results AFP≥400 ng/mL as primary liver cancer diagnostic threshold ,the sensitivity and specificity were 36% ,84% , when used AFP‐L3% ≥ 10% as primary liver cancer diagnostic threshold ,the sensitivity and specificity were 62% ,83% . Conclusion AFP‐L3% is a better clinical indicator to distinguish between primary liver cancer and benign liver disease .AFP‐L3%can be used as a clinical indicator to differential diagnosis between HBV infection of primary liver cancer and benign liver disease .

Objective To translate the Bergen Shift Work Sleep Questionnaire (BSWSQ) into Chinese, and test the reliability and validity of the Chinese version of BSWSQ. Methods Through the process of translation, back translation, expert consultation, and pre-test, the Chinese version of BSWSQ was formed. The reliability and validity was evaluated by the investigation in the 255 shift nurses. Results The Chinese version of BSWSQ consists of four shifts, including seven questions, each shift including six or five of them. By exploratory factor analysis, two or one common factor was extracted, and the cumulative contribution rates were 67.632%, 67.598%, 50.960% and 56.060% respectively. The content validity index was 0.939. The total Cronbach's α of the questionnaire was 0.915, and the Cronbach's α of each shift was 0.787 to 0.803. The retest reliability was 0.744 to 0.811. Conclusions The Chinese version of BSWSQ has good reliability and validity, and can be applied to the assessment of sleep condition of Chinese shift nurses.

Objective:To predict the status of microvascular invasion (MVI) in intrahepatic cholangiocarcinoma (ICC) patients preoperatively based on the radiomics analysis of contrast-enhanced CT to provide imaging evidence for early identification of patients at high risk of recurrence.Methods:Clinical data of 40 ICC patients who underwent radical hepatectomy at Nanjing Drum Tower Hospital from January 2021 to May 2024 were retrospectively collected. Patients were divided into the MVI group ( n=8) and the non-MVI group ( n=32) according to the MVI status of the postoperative pathology report. Whether there were differences in each pathological index between the groups and the efficacy of radiomics analysis of contrast-enhanced CT for the preoperative prediction of MVI were analyzed. The regions of interest (ROI) were outlined on the arterial and venous phase images using the 3D Slicer software. Then, radiomics features were extracted from each ROI based on Python. Finally, the LASSO regression and glm function were used to screen radiomics features and establish a prediction model based on the R language. The established predictive model′s diagnostic efficacy, calibration, and net clinical benefit were evaluated using the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA), respectively. Normally distributed measurement data were expressed as mean±standard deviation ( ± s) and compared using the t-test. Count data were expressed as frequency and compared using the chi-square test. Results:Patients in the MVI group had more poorly differentiated tumors and a significantly higher proportion of lymph node metastases ( P<0.05). The established radiomics prediction model included six features, 1 first-order statistical feature and 5 gray texture features. The area under the ROC curve was 0.87, the sensitivity was 75.0%, and the specificity was 90.6%. The calibration curve showed good agreement between the predicted MVI and actual MVI status, and the decision curve demonstrated that the model could provide a large net clinical benefit. Conclusion:Radiomics analysis of contrast-enhanced CT can identify the MVI status of ICC patients preoperatively and aid in clinical decision-making, providing vital evidence for individualized and precise treatment of ICC.