Objective To evaluate the effect of phosphocreatine in the treatment of infant with Pneumonia complicated with myocardial injury.Methods Sixty-eight infants with Pneumonia complicated with myocardial injury were randomized into treatment group (n = 36)and control group (n = 32) .The two groups were both treated with combined anti-infection, antiasthmatic and supporting treatments while the treatment group was given additional phosphocreatine.The ECG,recovery of myocardial enzymes, recovery time of major clinical symptoms and syndromes and the period of hospitalization of the two groups were compared.Results Recovery of ECG and myocardial enzymes in the treatment group (94.44％ and 94.44％)were significantly higher than those in the control group(78.13％ and 75.00％ ,respectively) (x2 =3.93 and 5.11 ,respectively,P ＜0.05).Recovery of clinical presentations were more rapid in the treatment group than that in control group (time for cough recovery, [9.5 ± 2.4]d vs.[11.1 ± 2.6]d ;time for rale disappearance, [8.1 ± 1.9]d vs.[10.3 ± 2.4]d) (t =2.63 and t =4.16 respectively ;P ＜0.05 and ＜0.01 respectively).The period of hospitalization was decreased markedly in the treatment group compared with that in the control group([11.5 ±2.2]d vs.[14.3 ±2.8]d) (t = 4.55, P ＜ 0.01) .ConclusionPhosphocreatine has prominent efficacy in the treatment of infantile Pneumonia complicated with myocardial injury.

OBJECTIVE: To carry out carrier screening for Spinal muscular atrophy (SMA) in reproductive-aged individuals from Dongguan region and determine the carrier frequency of SMN1 gene mutations. METHODS: Reproductive-aged individuals who underwent SMN1 genetic screening at the Dongguan Maternal and Child Health Care Hospital from March 2020 to August 2022 were selected as the study subjects. Deletions of exon 7 and 8 (E7/E8) of the SMN1 gene were detected by real-time fluorescence quantitative PCR (qPCR), and prenatal diagnosis was provided for carrier couples by multiple ligation-dependent probe amplification (MLPA). RESULTS: Among the 35 145 subjects, 635 were found to be carriers of SMN1 E7 deletion (586 with heterozygous E7/E8 deletion, 2 with heterozygous E7 deletion and homozygous E8 deletion, and 47 with sole heterozygous E7 deletion). The carrier frequency was 1.81% (635/35 145), with 1.59% (29/1 821) in males and 1.82% (606/33 324) in females. There was no significant difference between the two genders (χ² = 0.497, P = 0.481). A 29-year-old woman was found to harbor homozygous deletion of SMN1 E7/E8, and was verified to have a SMN1∶SMN2 ratio of [0∶4], none of her three family members with a [0∶4] genotype had clinical symptoms. Eleven carrier couples had accepted prenatal diagnosis, and one fetus was found to have a [0∶4] genotype, and the pregnancy was terminated. CONCLUSION This study has determined the SMA carrier frequency in Dongguan region for the first time and provided prenatal diagnosis for carrier couples. The data can provide a reference for genetic counseling and prenatal diagnosis, which has important clinical implications for the prevention and control of birth defects associated with SMA.
Humans ; Child ; Pregnancy ; Male ; Female ; Adult ; Homozygote ; Sequence Deletion ; Prenatal Diagnosis ; Genetic Testing ; Muscular Atrophy, Spinal/genetics* ; Survival of Motor Neuron 1 Protein/genetics* ; Genetic Carrier Screening

The Major of Medical Imaging Technology (Radiotherapy Technology Orientation) in West China Medical School, Sichuan University, has been devoted to training therapists, dosimetrists, and physicists in tumor radiotherapy, and it is urgently needed to improve the practice ability of interns and standardize the teaching system. In view of the current status of the practice of students in radiotherapy technology, this article analyzes and summarizes the teaching staff construction, teaching contents, teaching methods, and other aspects, finds out the problems and challenges in the current teaching system, and puts forward suggestions for practice teaching reform.