Objective: 1.To analyze the nutritional composition and evaluation of the nutritional value of Mortierella isabelina powder. 2.To investigate the effects of Mortierella isabelina powder on prevention and regulation of hyperlipidemia in rats. Methods: 1. Mycelium powder was analyzed for proteins, lipids polysaccharides, fibre, ash, vitamin E, amino acids, fatty acids and minerals. 2. Mycelium powder was used to feed rats in different dosages together with high lipid diet for 10 days. 3. Mycelium powder was used to feed hyperlipidemic rats in different dosages for 30 days. Results: (1) There were about 20% of proteins and more than 50% of lipids in the mycelium. Further examination found that the mycelium contained rich essential amino acids and unsaturated fatty acids. The mycelium also contained vitamin E and useful minerals such as K, Ca, P, Fe, Zn and Mn. (2) 0.6 or 1.2 g/(kg?d) dosage of mycelium powder could prevent the rise of serum lipids. (3) When the mycelium powder was used to feed hyperlipidemic rats, the serum cholesterol, triglyceride, LDL C and VLDL C of the rats could be reduced, meanwhile HDL C could be increased. Conclusion: The results indicated that Mortierella isabelina powder has potential nutritional value and can be used to regulate the blood lipids in hyperlipidemic rats.

Objective To study the benzylphenethylamine alkaloids from the bulbs and flowers of Lycoris radiata.Methods Alkaloids were isolated by various column chromatographic methods and their structures were identified by spectral data.Results Fifteen known benzylphenethylamine alkaloids were isolated and identified as lycoramine(1),O-demethyllycoramine(2),N-demethyllycoramine(3),galanthamine(4),lycorine(5),caranine(6),ungminorine(7),narciclasine(8),5-hydroxy-10-O-demethyl-homolycorine(9),hippeastrine(10),ungerine(11),hippeastrine N-oxide(12),O-demethylhaemanthamine(13),haemanthidine(14),and 8-demethoxybostasine(15).Conclusion Compound 15 is first isolated from the plants in Amaryllidaceae,compounds 3,6,9,and 11 are first reported from the plants in Lycoris Herb.,and compounds 2,7,and 14 are isolated from L.radiata for the fast time.The 13C-NMR data of compouds 3,7,and 12 are first reported in the present study.Furthermore,the galasine-type alkaloid is isolated from the plants of Lycoris Herb.for the first time.

Objective? To investigate the physical activity in the aged with dementia and explore its influencing factors to provide a basis for promoting those populations to participate in physical activity, protecting their cognitive function and improving their quality of life. Methods? From November 2018 to March 2019, this study selected the aged with dementia and their caregivers in Neurology Department, Cognition Outpatient and patient club of classⅢ grade A hospitals in Beijing and Zhejiang as subjects by purposive sampling. This study investigated patients' general information, disease condition, activity of daily life (ADL), physical activity, and caregivers' cognition as well as attitudes on patients' exercise, and concerns about fall of patients. Hierarchical regression was used to analyze the influencing factors of physical activity in the aged with dementia. A total of 232 questionnaires were sent out and 216 valid questionnaires were collected with 93.10% for the valid recovery rate. Results? The score of physical activity of the aged with dementia was [42.50 (11.43, 81.43)]mainly in walking outside the home and light household activities. The influencing factors of physical activity included education levels, ADL and caregivers' concerns about fall of patients with statistical differences (P＜ 0.01). Conclusions? Physical activity of the aged with dementia is lower than that of the healthy aged in community. On the one hand, the scientific, safe and suitable exercise plan should be formulated and implemented based on professional evaluation. On the other hand, health education on disease knowledge, symptom care and exercise guide for caregivers should be strengthened to rid off the worries of caregivers about fall of patients in exercises and improve physical activity of the aged with dementia.