1.Establishment of prolonged veno-venous extracorporeal membrane oxygenation support model in large animals
Jiachen QI ; Sizhe GAO ; Gang LIU ; Min ZHANG ; Qiaoni ZHANG ; Weidong YAN ; Yuan TENG ; Jian WANG ; Shujie YAN ; Chun ZHOU ; Qian WANG ; Bingyang JI
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery 2022;29(09):1166-1171
Objective To explore the safety and feasibility of the establishment method and management strategy of prolonged support model with veno-venous extracorporeal membrane oxygenation (V-V ECMO) under dual lumen cannula (DLC) in conscious sheep. Methods Three adult male sheep were selected. An Avalon Elite DLC was inserted into the superior vena cava, right atrium, and inferior vena cava through the right jugular vein and was connected with centrifugal pump and oxygenator to establish the extracorporeal membrane oxygenation circuit. All the 3 sheep were transferred into the monitoring cage after operation and were ambulatory after anesthesia recovery. Hemodynamic parameters and extracorporeal membrane oxygenation performance were measured every day. Results All three sheep survived to the end of the experiment (7 days). In the whole process of the experiment, the basic vital signs of the experimental sheep were stable, and no serious bleeding or thrombotic events occurred. During the experiment, hemoglobin concentration and platelet count were relatively stable, plasma free hemoglobin was maintained at a low level, extracorporeal membrane oxygenation flow rate was stable, and oxygenation performance of oxygenator was good. Conclusion Prolonged V-V ECMO model in conscious sheep under DLC is feasible and stable.
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