The treatment of tumors continues to be significantly challenging. The presence of multiple modalities, including surgery, radiation, chemotherapy and immunotherapy, the therapeutic outcomes remain limited and are often associated with adverse effects and inconsistent efficacy across cancer types. Recent studies have highlighted the potential of active components from traditional Chinese medicine (TCM) for their anti-cancer properties, which are attributable to multi-targeted mechanisms and broad pharmacological actions. Despite this potential, TCM-derived compounds are commonly limited by poor water solubility, low bioavailability, and suboptimal targeting. Currently, it is believed that advances in nanotechnology could address these limitations. Nanoparticles (NPs), which possess properties such as enhanced bioavailability, controlled release and precise targeting, have been used to improve the therapeutic efficacy of TCM components in cancer therapy. This review discusses the use of NPs for the delivery of active TCM compounds via organic-inorganic nanocarriers, highlighting innovative strategies that enhance the effectiveness of TCM-based anti-tumor components to provide insights into improving clinical outcomes while advancing the modernization and global application of TCM in oncology.
Animals ; Humans ; Antineoplastic Agents/therapeutic use* ; Drug Carriers/chemistry* ; Drug Delivery Systems ; Drugs, Chinese Herbal/therapeutic use* ; Medicine, Chinese Traditional/methods* ; Nanoparticles/chemistry* ; Neoplasms/drug therapy*

Objective To explore the clinical characteristics and prognostic factors of primary gastric lymphoma.Methods Clinical data of 78 primary gastric lymphoma patients treated between September 2012 and January 2017 in our hospital were analyzed retrospectively.Results 1-year and 3-year survival rate were 86％ and 68％ respectively.Univariate analysis showed that the four factors including the level of serum lactate dehydrogenase (x2 =35.088,P =0.000),Musshoff stage (x2 =29.930,P =0.000),pathology types (x2 =6.077,P =0.014),IPI score (x2 =21.337,P =0.000) were associated with the prognosis.Multivariate analysis showed that Musshoff stage was an independent risk factor for the prognosis when stage Ⅰ,stage Ⅱ (OR =1.075,95％ CI:0.060-19.107,P =0.961) were compared with stageⅢ (OR =11.994,95％ CI:1.042-138.083,P =0.046),or stage Ⅳ (OR =13.165,95％ CI:1.476-117.417,P =0.021).Conclusions Musshoff stage is an independent factor for the prognosis,surgical treatment can not prolong survival and chemotherapy is the therapy of choice.

OBJECTIVE: To study the antitussive, antiasthmtic, anti-inflammatory and diuretic effects of Herba Ephedrae cultivated artificially in Gansu province and to compare which with the wild Herba Ephedrae. METHODS: Each pharmacological action index was determined by concentrated ammonia method, windpipe capacity method, pinna swelling method and metabolic cage method. RESULTS: Both of the two kinds of Herba Ephedrae could reduce the cough responses of mice, resist the spasmodic contraction of the tracheal smooth muscles, reduce the swelling of auricle of mice and increase urine volume of rats. CONCLUSIONS: Herba Ephedrae cultivated artificially in Gansu province are equivalent to the wild one in terms of the antitussive, antiasthmtic, anti-inflammatory and diuretic effects thus it can serve as a substitute for the wild one.