Objective To study the expression of epidermal growth factor receptor (EGFR) in cervical car-cinoma and cervical intraepithelial neoplasia(CIN),and to elucidate its relation with the genesis, infiltration, metas-tasis and prognosis of cervical carcinoma. Methods EGFR was determined by means of S-P immunohistochemistry in tissue of 100 cases of cervical carcinoma,60 cases of CIN and 40 cases of controls. Results The overexpression rates of EGFR were 0% (0/40), 51.67% (31/60),78.00% (78/100), respectively in normal cervical epithelium, CIN and cervical tumor tissues. The overexpression rate of EGFR was significantly higher in cervical tumor tissue than in control group(P<0.01). The overexpression of EGFR didn't demonstrate significant association with clinical staging, tumor size, pathological type, differentiation, cervical invasion depth, cervical canal invasion, lymphnode me-tastasis or the prognosis of cervical neoplasm (P>0.05). Conclusion Overexpression of EGFR is worsened with the severity of cervical lesion, suggesting that overexpression of EGFR is correlated with the genesis of cervical neo-plasms,which may be a valuable biological indicator of cervical carcinoma,but is not correlated with clinical patho-logical features and prognosis of cervical carcinoma.

Objective : To evaluate the effect of 2. 5% NaClO solution as irrigating agent on the healing of dental pulp after preservation treatment in rats with inflammatory pulp. Methods : 48 maxillary molars of 24 8 ⁃week⁃old male SD rats were selected and pulpitis models were established by pulp cavity exposure for 24 hours. Then part of the crown pulp was removed and divided into two groups according to different irrigation methods : 2. 5% NaClO flushing group (NaClO) and saline flushing group (NS) . The pulp was covered with iRoot BP Plus and the cavity was sealed with glass ionomer. Four animals in the two groups were killed on the 1st , 7th and 28th day after opera⁃ tion , respectively. And the inflammatory reaction , tissue destruction and hard tissue formation of residual dental pulp tissue were observed and evaluated by histopathology. Results : The pulp inflammatory reaction , tissue de⁃ struction and restorative dentin formation in 2. 5% NaClO irrigation group and saline irrigation group were similar on the 1st , 7th and 28th day after operation , there was no significant difference between the two groups. Conclusion 2. 5% NaClO used as a hemostatic before iRoot BP Plus pulp capping after partial pulpotomy has similar effect with normal saline on the inflammatory pulp model of rats , and does not affect the healing of pulp inflammation.