Analysis of regular elements in promoter region is the base for elucidating the mechanism of gene transcription initiation.The TATA and the TATA-less promoters of plant RNA polymerase Ⅱ gene are chosen from the PlanPromDB.The GC bias,position structure conservation,nucleotide content and conservative motifs of sequences,position distribution of TATA box and conservation of correlation position are analyzed.Many specific regulars for the two types of promoters are found.These features can offer some help for revealing the transcription regulation of plant gene.A new prediction algorithm based on position-correlation weight matrix(PCWM) is proposed.The better discrimination results for two sort plant promoters are obtained by using score function.It is confirmed that the performance of position-correlation weight matrix(PCWM) is superior to single-base position weight matrix(PWM).

AIM To analyze the mechanism of the adriamycin induced cardiomyopathy. METHODS The patch clamp technique in the whole cell recording was used to study the effect of adriamycin on L type calcium channel current( I Ca L ) in the isolated cardiomyocyte of the guinea pig. RESULTS The current voltage( I U ) curveshowed the bell shape in the control and in 0 1 mmol?L -1 adriamycin. Their peak potentials were about +10 mV. The amlitude of peak calcium current increased from (-0 93?0 05) nA to (-1 31?0 08) nA( P