1.The function of Chinese herbal medicine in the reconstruction of periodontal tissue during orthodontic tooth movement
Yazhu CHEN ; Xiaoyan GUAN ; Qianwen XIAO ; Siwei WANG ; Jianguo LIU
Chinese Journal of Tissue Engineering Research 2014;(46):7477-7481
BACKGROUND:Orthodontic tooth movement is based on the periodontal tissue remodeling. In the exogenous factors accelerating orthodontic tooth movement, Chinese herbal medicine has become a research hotspot because of its wide resources, low cost, easy to extract, mild effect, smal toxic, less side effects and drug resistance. OBJECTIVE: To summarize the role of Chinese herbal medicine in the periodontal tissue remodeling during orthodontic tooth movement. METHODS:A computer-based retrieval of CNKI, Wanfang and PubMed databases was performed for articles related to Chinese herbal medicine for improving orthodontic tooth movement published before 2014. The keywords were “Chinese herbal medicine, orthodontic tooth movement, periodontal tissue remodeling” in Chinese and English, respectively. RESULTS AND CONCLUSION:Erigeron breviscapus, Salvia, teasel, Drynaria, baicalin, evening primrose oil as Chinese herbs are most widely used in the promotion of periodontal tissue remodeling, characterized as wide resources, low cost, easy to extract, mild effect, low toxicity, less drug resistance. In the clinical orthodontic treatment, it is hoped to accelerate orthodontic tooth movement and shorten the treatment time. Therefore, under the appropriate corrective force, Chinese herbs can be used properly to improve periodontal tissue repair and remodeling, which can improve the microcirculation of periodontal tissue, increase the local blood flow, promote bone formation and repress bone resorption.
2.Comparison study between main influencing factors and diurnal variation of net photosynthetic rate in different types of Pueraria thomsonii.
Dongmei MAO ; Qianwen XIAO ; Sen LI ; Shi SHU ; Dinggen CHEN
China Journal of Chinese Materia Medica 2010;35(22):2954-2958
OBJECTIVETo study the diurnal variation of net photosynthetic rate (P(n)) and main influencing factors in different types of Pueraria thomsonii, aimed at providing the theoretical basis for breeding the fine varieties of P. thomsonii suitable for the local light condition.
METHODDiurnal variations of photosynthesis in leaves of different types of P. thomsonii were determined with the Li-6400 Portable Photosynthesis System.
RESULT(1) Diurnal variation of P(n), transpiration Rate (T(r)), stomatal conductance (G(s)) in leaves of six varieties of P. thomsonii showed unimodal curve and asymmetric bimodal curve. Diurnal variation of water use efficiency (WUE), intercellular CO2 concentration (C(i)) showed single valley curve. Diurnal variation curve of stomatal limitation value (L(s)) was single peak and S-type. (2) P(n) in leaves of six varieties of P. thomsonii was positively correlated with photosynthetic active radiation (PAR), air temperature (T(a)), G(s), and negatively correlated with air relative humidity (RH), C(i), P(n) of all varieties were very significantly correlated with PAR, G(s).
CONCLUSIONDiurnal variations of photosynthesis in leaves of different types of P. thomsonii show significant difference. Jiuding, Chuanyu, Gange, Dijin No. 1 planted in Ya'an overcome "midday depression" phenomenon. Hechuan has the greatest photosynthetic potential, suitable for planting in forest understory and intercropping with high stalk to avoid the strong flashes. Planted in long-day region was beneficial to its growth. CO2 use efficiency of Geboshi No. 11 and Dijin No. 1 were significantly higher than that of the others. The accumulation efficiency of organics can be increased in cultivation management by fertilizing CO2.
Carbon Dioxide ; metabolism ; Light ; Photosynthesis ; Pueraria ; metabolism ; radiation effects
3.Role of Nrf2/HO-1 Signaling Pathway in Osteoporosis and Chinese Medicine Intervention: A Review
Jirong ZHAO ; Peng JIANG ; Wen CHEN ; Xiaping XIAO ; Xingsheng WANG ; Qianwen CHEN ; Junfei MA ; Zhenghan YANG
Chinese Journal of Experimental Traditional Medical Formulae 2022;28(20):241-249
Osteoporosis is a chronic skeletal disease characterized by low bone mass, destruction of bone tissue microarchitecture, and imbalance of bone homeostasis, leading to increased bone fragility and increased risk of fractures. Oxidative stress caused by the disruption of the balance between excess reactive oxygen species (ROS) and the anti-oxidative system is an important factor in the occurrence and progression of osteoporosis. Nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) is an important anti-oxidative stress pathway. Nrf2 is a primary factor in regulating cellular oxidative stress. Activating Nrf2 can stimulate the expression of HO-1. HO-1 is a key enzyme whose metabolites are bile green Oxygen, carbon monoxide, and free iron. The metabolites can scavenge ROS, thereby exerting an antioxidant effect in cells. At present, domestic and foreign scholars have reported that the Nrf2/HO-1 signaling pathway is closely related to the occurrence and development of osteoporosis and the mechanism of drugs. Chinese medicine can effectively solve the insufficiency of western medicine with multi-target, multi-channel, and multi-level advantages. Chinese medicine can resist oxidative stress, inflammatory response, and apoptosis by regulating the Nrf2/HO-1 signaling pathway, thus treating osteoporosis. This article reviewed the relationship between Nrf2/HO-1 signaling pathway and its key target protein factors and osteoporosis, to clarify the important role of the Nrf2/HO-1 signaling pathway in osteoporosis. At the same time, a systematic summary of Chinese medicines targeting and regulating the Nrf2/HO-1 signaling pathway for the treatment of osteoporosis was conducted, to provide a theoretical basis for further precise treatment of osteoporosis.
4. Efficacy and associated factors of olfactory training in the treatment of olfactory dysfunction
Xiaoguang YAN ; Xing GAO ; Zhifu SUN ; Yichen GUO ; Linyin YAO ; Jia LIU ; Wei XIAO ; Qianwen LYU ; Yongxiang WEI
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2018;53(11):815-819
Objective:
To explore the clinical effects and the influence factors of olfactory training in the treatment of olfactory dysfunction.
Methods:
A total of 86 patients with olfactory dysfunction (49 post-infectious and 37 post-traumatic) in Beijing Anzhen Hospital during Dec 2016 to May 2017 were recruited in this prospective study. The clinical data of patients were analyzed, including gender, age, body mass index (BMI), course of disease, smoking history, drinking history, diabetes history, hypertension history, hyperlipidemia history, and anxiety visual analogue score (VAS). All patients were treated with olfactory training for 16 weeks, and all of them underwent Sniffin′ Sticks olfactory test before and after treatment, which was evaluated by composite threshold-discrimination-identification score (TDI). SPSS 23.0 software, paired
5.Numerical Analysis on Adaptability of Valve Leaflets after Single Valve Replacement in Children
Ning LIU ; Qianwen HOU ; Sicong LIU ; Xiao LI ; Youlian PAN ; Aike QIAO
Journal of Medical Biomechanics 2021;36(6):E869-E876
Objective To explore the biomechanical mechanism of aortic insufficiency (AI) after single aortic valve replacement (SAVR) in children and propose the corresponding countermeasures. Methods The idealized aortic valve model and postoperative growth model were constructed. By changing the length of leaflet free edge, leaflet height as well as improving the design with a concave structure, the effects of different structure dimensions on movement synchronization and closing performance of the aortic valve after surgery were compared. Results The closure of the replacement leaflet lagged behind the autologous leaflet, which fitted 2 mm below free edge of the replacement leaflet. AI occurred 6 years after operation. Increasing leaflet height could not improve the postoperative effect and would increase the maximum stress of the leaflet. Increasing free edge length by 10% could improve the postoperative outcomes, while increasing free edge length by 15% would cause the leaflet to be too long, hence resulting in a poor fit of the aortic valve. Compared with the traditional structure, the concave structure was more beneficial for closing performance of the aortic valve, and it could effectively reduce the maximum stress by 20% with the best effect. Conclusions The leaflet movement will be out of synchronization after SAVR, the point of convergence will be shifted, and AI will appear 6 years after surgery. It is recommended to use a concave structure with free edge length increased by 10%, while increasing leaflet height is not recommended.