Objective To compare the therapeutic efficacy of various thrombolytic ways for deep venous thrombosis of lower extremity (DVTLE). Methods Three ways of medications were used in this series,one way was via systematic,one way was via local deep vein by puncture, and another way was to block the proximal and the medication was given through the distal part of the great saphenous vein.Results The 3 thrombolytic ways on treating DVTLE had different efficacies.The best way was the latest way. Conclusions The best way in treating DVTLE is local thrombolysis via superficial vein medication.