Objective To investigate the analgesia effects and adverse effect of the monitored anesthesia care of remifentanil assisted by cervix nerves block and the propofol intravenous general anesthesia on abortion.Methods Eighty patients with ASA Ⅰ-Ⅱ were selected and divided into the group of propofol intravenous general anesthesia (E group,n =40) and the group of the monitored anesthesia care of remifentanil assisted by cervix nerves block (R group,n =40).Heart rate (HR),respiratory rate (RR),mean arterial pressure(MAP),oxygen saturation(SpO2) were recorded before,during and after the operation.Operative time,respiratory depression time,recovery time,VAS score,hospital time and patient satisfaction of the patients in the two groups were recorded.Results The MAP,HR,RR,SpO2 of the patients in the two groups after analgesia were significantly decreased compared with that of before analgesia (P ＜ 0.05 or P ＜ 0.01).The levels of RR,SpO2 in R group after analgesia were obviously lower than that in group E (P ＜ 0.05).The cases number who occurred incidence of injection pain,physical movement in E group were higher than that in R group(injection pain:11 cases vs.0 case,P =0.0004 ; Physical movement:4 cases vs.0 case,P =0.0402).The wake up time and the period of staying in hospital in E group were longer than that of R group(wake up time:(5.01 ±0.75)min vs.(0.00 ± 0.00) min,t =-42.248,P =0.000 ; Time from hospital:(27.78 ± 4.65) min vs.(18.68±3.80) min,t =-9.584,P =0.000).The analgesic effects of VAS in E group was (0.00 ±0.0),better than that of group R ((0.45 ± 0.09),t =3.162,P =0.002).The satisfaction rate in two groups were 100％.Conclusion The method of monitored anesthesia care of remifentanil assisted by cervix nerves block is proved to be better than that of propofol intravenous general anesthesia at induced abortion regarding of precise monitored anesthesia pain management techniques,stable hemodynamics,rapid postoperative recovery,adverse reactions and shorten the time from the hospital,which was better than propofol anesthesia,and is a safe and effective method of anesthesia.

The anterior disc displacement (ADD) leads to temporomandibular joint osteoarthritis (TMJOA) and mandibular growth retardation in adolescents. To investigate the potential functional role of fibrocartilage stem cells (FCSCs) during the process, a surgical ADD-TMJOA mouse model was established. From 1 week after model generation, ADD mice exhibited aggravated mandibular growth retardation with osteoarthritis (OA)-like joint cartilage degeneration, manifesting with impaired chondrogenic differentiation and loss of subchondral bone homeostasis. Lineage tracing using Gli1-CreER⁺; Tm^fl/-mice and Sox9-CreER⁺;Tm^fl/-mice showed that ADD interfered with the chondrogenic capacity of Gli1⁺ FCSCs as well as osteogenic differentiation of Sox9⁺ lineage, mainly in the middle zone of TMJ cartilage. Then, a surgically induced disc reposition (DR) mouse model was generated. The inhibited FCSCs capacity was significantly alleviated by DR treatment in ADD mice. And both the ADD mice and adolescent ADD patients had significantly relieved OA phenotype and improved condylar growth after DR treatment. In conclusion, ADD-TMJOA leads to impaired chondrogenic progenitor capacity and osteogenesis differentiation of FCSCs lineage, resulting in cartilage degeneration and loss of subchondral bone homeostasis, finally causing TMJ growth retardation. DR at an early stage could significantly alleviate cartilage degeneration and restore TMJ cartilage growth potential.
Animals ; Mice ; Osteogenesis ; Zinc Finger Protein GLI1 ; Fibrocartilage ; Temporomandibular Joint ; Disease Models, Animal ; Osteoarthritis ; Stem Cells ; Growth Disorders