Objective:To research and design a closed-loop management system of medical equipment based on virtualized cloud computing so as to enhance the level of maintenance management for medical equipment and reduce cost of maintenance.Methods: Under the operation environment of Cente OS6.4, the closed-loop management system of medical equipment was designed and developed through used design tool of Rational Rose 2007, programming software of JAVA and My SQL data management system.Results: After the management system were used one year, medical workers could real-timely grasp the situation of medical equipment and the communication time about application of equipment has been reduced. The management department of medical equipment could guide clinical department to reasonably allocate and use the medical equipment through implemented closed-loop and dynamic management.Conclusion: The closed-loop management system of medical equipment based on virtualized cloud computing has series of advantages including friendly interface, simple operation, shortened communication time, reduced cost of maintenance, and it can achieve closed-loop management of whole life cycle for medical equipment.