1.The risk factors of capillary leak syndrome after extracorporeal bypass in infants
Xiaojun HE ; Qiang SHU ; Linhua TAN
Chinese Journal of Emergency Medicine 2008;17(6):642-645
Objective To determine risk factors and treatments of capillary leak syndrome (CLS) in infants with congenital heart disease(CHD)after extracorporeal bypass (GBP) . Method A retrospective study of 38 infants with CIS and another 150 cases without CLS of a random choice who underwent extracoiporeal bypass from June 2003 to July 2007 was carried out.Several risk factors with statistical significance were screened out with uni-varite logistic regression analysis, and the independent rask factors of CLS were determined with inultivariate step-wise logistic regression analysis. The outcome of CIS infants was compared with infants of control group. Results Logistic analysis showed the risk factors of CLS were the duration of GBP ( OR = 10. 353) , type of CHD ( OR = 6. 912), age ( OR = 6. 254) and temperature of CBP ( OR = 4. 151) . Of the CLS infants cohort, 10 cases underwent peritoneal dialysis and 4 cases died. Conclusions The risk factors of CLS in infants after CBP are the length of time consumed during CBP, type of CHD, age and temperature of CBP.
2.The research of 64-slice spiral CT in assessing the mild and severe stenosis of coronary artery
Chunpeng MA ; Qingsheng WANG ; Qiang TAN
Chinese Journal of Postgraduates of Medicine 2008;31(16):22-24
Objective To evaluate the accuracy of 64-slice spiral CT(64 SCT)in assessing the mild and severe stenosis of coronary artery.Methods A total of 72 patients suspected to suffer from coronary artery disease underwent orderly both 64 SCT and selective coronary angiography(SCAG).Volume rendering (VR),multi-planar reconstruction(MPR),maximum intensity projection(MIP)and transverse section wasused to analyze the 64 SCT data.The results were compared with those of SCAG to investigate the accuracy of the 64 SCT in assessing the≥50% stenosis of coronary artery.Results In the 720 SCAG segments of 72 patients.684 of them could be evaluated by 64 SCT.The evaluated rate Was 95.0%.Compared with SCAG,the sensitivity,specificity,positive predictive value,negative predictive value and accuracy rate was 67.4%,92.9%,69.5%,92.3% and 88.0% respectively.Conclusion The accuracy of 64 SCT in assessing mild and severe stenosis is relatively high and it can be used for screening patients with suspected coronary artery diseases as a non-invasive method.
3.The role of nuclear factor-κB pathway on carcinogenesis and therapy of thyroid cancer
Zhaowei MENG ; Qiang JIA ; Jian TAN
Chinese Journal of Nuclear Medicine and Molecular Imaging 2014;34(5):415-418
The incidence rate of thyroid cancer is increasing very rapidly during the past years.131I treatment for DTC is an effective method.However,DTC refractory to 131I treatment or therapeutic failure is not uncommon.High level expression of nuclear factor-kappa B (NF-λB) in thyroid cancer is closely related with carcinogenesis,progression,anti-apoptosis and therapeutic resistance.NF-κB inhibitor was effective for the treatment of thyroid cancer.Combined NF-κB inhibitor with131I may improve the therapeutic efficacy.
4.Therapeutic efficacy of Voriconazole on invasive fungal infections in very elderly patients
Mengmeng LI ; Jin TAN ; Xu AN ; Qiang ZHANG
Chinese Journal of Geriatrics 2016;35(5):487-489
Objective To evaluate the safety and efficacy of Voriconazole on invasive fungal infections in very elderly patients.Methods Clinical data of 24 very elderly patients with invasive fungal infections who had sought treatment at the Department of Geriatrics of our hospital from April 2013 to April 2014 were retrospectively investigated.The classifications and quantities of fungi,accompanying symptoms,adverse reactions,blood tests,and liver and kidney function indicators were recorded and analyzed before and after treatment.Results Each of the 24 cases was found to have been infected with one or more of 17 fungal strains belonging to the genus of Candida.The rate of complete fungal elimination after treatment was 70% (12/17).Of the 24 cases,5 achieved a full recovery(20.8 %),10 (41.7 %) had significant improvement,5 (20.8 %) had some improvement,and 4 cases(16.7%)showed no therapeutic benefits,with a total effectiveness rate of 62.5 %.There was no significant difference in liver and kidney function before and after treatment(P>0.05).A transient increase in serum creatinine occurred in 1 case and defective vision in another patient during Voriconazole treatment.Conclusions The incidence of invasive fungal infections is high in very elderly patients,with Candida as the main pathogen.Voriconazole is effective in treating invasive fungal infections in very elderly patients,and close monitoring of liver and kidney function is required during voriconazole treatment.
5.Effect of STAT3 siRNA on proliferation and apoptosis of gastric cancer cells in vitro
Wei ZHANG ; Qiang WU ; Deming TAN
Journal of Third Military Medical University 2003;0(07):-
Objective To design and construct a vector of signal transducer and activator of transcription 3 (STAT3) small interfering RNA (siRNA),and to investigate the effect of the recombinant plasmid on the proliferation and apoptosis of gastric cancer cell SGC7901. Methods The PAVU6+27-STAT3 siRNA expression vector was constructed, then transfected into the cultured gastric cancer cells SGC7901 by DOTAP method. STAT3 mRNA and protein in SGC7901 were determined by RT-PCR and Western blotting respectively. Cell proliferation was tested by MTT and 3H-TdR incorporation. Cell apoptosis percentage and bcl-2 expression were observed by TUNEL and flow cytometry respectively. Results The PAVU6+27-STAT3 siRNA expression vector was successfully constructed. In the transfected SGC7901 cells, cell proliferation, 3H-TdR incorporation and bcl-2 expression were decreased, and cell apoptosis percentage was increased. Conclusion PAVU6+27-STAT3 siRNA expression vector may be an efficient method to inhibit the proliferation and promote the apoptosis of gastric cancer cells.
6.Effect of Epidural Anesthesia With 0.375% Ropivacaine on Hemodynamics in Breast Cancer Radical Operation
Xiaobin WANG ; Xianlin TAN ; Qiang QU
Journal of Chinese Physician 2000;0(12):-
Objective To observe the changes of hemodynamics during 0 375% ropivacaine epidural anesthesia period,and 0 375% bupivacaine as control in patients have undergoing breast cancer radical operation.Methods Sixty-one patients were randomly designed to receive 0 375% ropivacaine(groupⅠ,n=30)or 0 375% bupivacain(groupⅡ,n=31)epidural anesthesia respectively during breast cancer radical operation.BP,HR and SpO 2 were assessed at 5min,10min,15min and 20min after first full doses.Results The changes of BP,HR and SatO 2 at 5min,10min,15min and 20min after first full doses were obviously lower in groupⅠ than that in groupⅡ(P0 05).No severe adverse event was found during the observation.Conclusions Interference of epidural anesthesia with 0 375% ropivacaine on hemodynamics in breast cancer radical operation is slighter than that of 0 375% bupivacaine.
7.Effect of Vehicle Exhaust Pollution on Lung Function and Inflammatory Factors Level in Pupils
Qiang TAN ; Hong SONG ; Suimei CHEN
Journal of Environment and Health 2007;0(09):-
Objective To explore whether pollutants exposure has a measurable impact on lung function and inflammatory factors level of healthy pupils in vehicle exhaust polluted region. Methods Primary school near the trunk road with a distance no more than 30 meters was selected,and 50 qualified pupils were chosen. A time-series panel study was conducted with these pupils,and the following consecutive five days'study of vehicle exhaust pollution level,3-days’personal exposure measurement and its health effects were carried out in May and November in 2008. Results The main pollutant in this region was motor vehicle exhaust. Compared to May,the value of FVC% declined significantly in November(P=0.02) . And the reduction of the value of FVC% was negatively associated with an increase in NO2 concentrations(P=0.04) . The levels of IL-2,IL-6,IL-8 became lower in November compared with May,and were negatively associated with personal exposure with IL-6 with statistically significant difference(?PM10=-0.62,?NO2=-0.62,?O3=-0.64,?SO2=-0.63) . The levels of TNF-? and IL-4 were positively associated with personal exposure,in which PM10 has the largest regression coefficient with TNF-?(?=0.65,P
8.Investigation on occupational hazards of non-coal mines in Hunan Province in 2021
GAO Ying TAN Qiang PENG Ren he
China Occupational Medicine 2022;52(04):477-
Abstract: Objective -
To understand the status of occupational hazards in non coal mine mountains in Hunan Province.
Methods - -
A cross sectional survey was conducted on 432 non coal mining enterprises in Hunan Province in 2021. The field
,
occupational health survey occupational disease hazard factors detection and occupational health monitoring data analysis were
Results -
carried out. Limited liability companies and private enterprises were the main economic types of non coal mining
, ,
mountains in Hunan Province accounting for 55.3% and 32.4% respectively. The size of enterprises was mainly small and
, ; -
micro enterprises accounting for 59.3% and 35.2% respectively 78.0% of the enterprises were in non metallic mining. The
- ,
over standard rates of silica dust and noise in workplaces were 17.1% and 29.4% respectively. The exposure rate of
, (P )
occupational hazard factor was 47.3%. The smaller the enterprise scale the higher the exposure rate <0.01 . The number of
, ,
people exposed to silica dust and noise was the largest with the exposure rate of 29.4% and 31.0% respectively. The rates of
,
occupational health training for persons in charge of enterprises occupational health management personnel and workers were
, , ,
73.8% 73.4% and 85.0% respectively. The smaller the enterprise scale the lower the occupational health training rates of
, ,
enterprise leaders occupational health management personnel and workers and the lower the implementation rates of
( P ) - -
enterprise occupational health examination all <0.05 . The fully installed rate and effective rate of occupational disease
;
prevention facilities were 6.9% and 1.6% respectively and the fully deployed rate and effective wearing rate of personal
,
protective equipment were 11.1% and 6.2% respectively. The detection rates of occupational contraindications and suspected
, Conclusion
occupational diseases in workers exposed to silica dust and noise were 2.0% and 2.9% respectively. The
- ,
occupational risks such as silica dust and noise are serious in non coal mine mountains of Hunan Province and the foundation of
occupational health management is weak in small and micro enterprises.
9.Analysis of individual dose monitoring results for medical radiation workers from occupational external exposure in Chongqing City, 2016-2020
HUANG Qiang ; TAN Qiang ; TANG Ping ; HUANG Rui
China Tropical Medicine 2023;23(5):545-
Abstract: Objective To retrospectively analyze the individual dose monitoring of radiation workers in Chongqing City from 2016 to 2020, so as to provide scientific reference for occupational health monitoring and radiation protection. Methods Radiation workers who performed individual dose monitoring in Chongqing Center for Disease Control and Prevention from 2016 to 2020 were selected as the research objects, and the monitoring data were collected and analyzed. Results A total of 40 926 individuals were included in this study, with a total of 135 622 person-years. The average annual individual effective dose of radiation workers over the five-year period was 0.56 mSv. NR1 and NR5, the ratio of the number of works receiving annual individual does exceeding 1 and 5 mSv to the to the total monitor workers were 13.019% and 0.335%. The annual effective dose per capita in Chongqing City showed a trend of first decreasing, then increasing and then decreasing again over the study period, with significant differences between different years (F=971.754, P<0.001). Although there were some differences in the variation trend of annual effective dose among different occupational categories, the overall trend was decreasing year by year. The average annual effective dose of nuclear medicine and interventional radiology was relatively high, and the difference was not statistically significant (P>0.05). The average annual effective dose of industrial flaw detection and accelerator operator in industrial application was relatively higher, and the difference was not statistically significant (P>0.05). There were statistically significant differences in the per capita effective doses of different occupational categories of medical application in different years (F=8.892-682.852, P<0.001). Among them, the per capita annual effective doses of five occupational categories of medical application were the highest in 2016, and the per capita annual effective doses of interventional radiology were the highest in 2018 and 2019. Conclusions The per capita annual effective dose of radiation staff in Chongqing has decreased year by year from 2016 to 2020, and remained at a relatively low level that meets national standards. The monitoring results suggest that the radiation staff of nuclear medicine, interventional radiology, industrial non-destructive testing and accelerator operator should give special attention to protect their occupational health and safety.
10.Sialolithiasis of the left upper lip: a case report.
Yu LUO ; Qiang ZHANG ; Chunyuan LUO ; Linlin CHEN ; Weibing TAN
West China Journal of Stomatology 2014;32(5):525-526
Sialolithiasis is a common disease of the salivary gland. This disease mainly involves the major salivary gland. Sialolithiasis of the minor salivary gland is rare. A case of sialolithiasis of the upper lip was reported, and relevant literature was reviewed in this paper.
Humans
;
Lip
;
Mouth Mucosa
;
Salivary Gland Calculi
;
Salivary Glands, Minor