Cardiovascular System ; drug effects ; Humans ; Trans Fatty Acids ; adverse effects

Erectile dysfunction was one of the most frequently postoperative complications after radical prostatectomy,which has been deeply concentrated by patients and urologists,along with more and more people were diagnosed as localized prostate cancer.Widely being used for erectile dysfunction after radical prostatectomy,the efficacy and safety of phosphodiesterase type 5 inhibitors have been confirmed by many clinical studies.However,the influences of phosphodiesterase type 5 inhibitors on the occurrence and progression of cancer are still not completely revealed at present.Additionally,the efficiency of phosphodiesterase type 5 inhibitors on biochemical recurrence after radical prostatectomny is still controversial,though it has been demonstrated that phosphodiesterase type 5 inhibitors is not associated with the occunrence of prostate cancer based on recent clinical studies.We will review the possibly mechanisms of phosphodiesterase type 5 inhibitors in oncologic occurrence,especially in the occurrence of prostate cancer and its biochemical recurrence after radical prostatectomy.

There is a close relationship between high trans fatty acids intake and occurrence of metabolic syndrome. Trans fatty acids intake may lead to metabolic disorders. It affects lipid level, induces visceral obesity and insulin resistance, triggers systemic inflammation, and significantly increases cardiometabolic risks. If the chain of trans fatty acids-metabolic syndrome-cardiovascular disease is understood, a new effective way to prevent metabolic syndrome and cardiovascular events may be provided.

Objective To present 3 cases of neurilemmoma of adrenal gland. Methods The clinical pathological manifestations,diagnosis and treatment of 3 cases of neurilemmoma of adrenal gland were reviewed. Results Tumor resection was undertaken in all the three and the diagnosis was assessed on pathological study. All the 3 patients have been in good condition and tumor free on 3～5 years of follow up. Conclusions Tumor resection is the treatment of choice with good prognosis.Radiotherapy may be considered as an adjuvant treatment for malignant ones.Definite diagnosis depends on pathological studies.

Hearing ; Hearing Aids ; Prostheses and Implants

Purpose:Evaluate the operation methods and prognosis following Ivor Lewis subtotal esophagectomy with two-field lymphadenectomy for carcinoma of the middle and lower third of the oesophagus. Methods:From March 1997 to March 2001, A total of 356 consecutive patients underwent Ivor Lewis esophagogastrectomy with two-field radical lymphadenectomy for carcinoma of the middle and lower third of the oesophagus ,The patients received cupula of pleura or cervical esophagogastroanastomosis with mechanical methods through two incisions (right posterolateral thoracotomy and upper abdominal).Results:The post-operative mortality was 0. anastomotic leakages occurred in 3 patients(0.8%). Gastric leaks for stress gastric ulcer occurred in 2 patients (0.6%). Chylothorax occurred in 2 patients(0.6%). Hoarseness occurred in 5 patients(1.4%),4 cases recuperated after 3 months. Barium swallowed postsurgery through anastomosis and pylorus went through smoothly.Full follow-up was 97.2%. Median survival for operative survivors was 2.6 years (range,61 days to 5 years). The overall 3-year survival rate was 74.5% .The overall 5-year survival rate was 55.49%,it was 94.2% for those in stage Ⅰ,81.5% for those in stage Ⅱa,78.3% for patients in stage Ⅱb,36% for those in stage Ⅲ and 0% for patients in stage Ⅳ. Conclusions:Ivor Lewis esophagogastrectomy with two-field radical lymphadenectomy for carcinoma of the middle and lower third of the oesophagus is a safe operation. There is the low post-operative morbidity. Long-term survival have been improved.

[Objective]To improve the preparative method of catilage derived microcarrier and evaluate the micromechanism and biocompatibility of this metarial for injectable tissue engineering cartilage.[Methods]Fresh porcine articular cartilage were obtained and shattered in the iso-osmia liquid in 4℃.After gradient centrifugation,150-300 ?m size cartilage micelles were gathered and were subjected to 1% Triton X-100 once and physiological saline twicely.The structure of specimens were observed and assessed by inverted phase contrast microscopy,environmental scanning electron microscope.And the composition of these specimens were stained with haematoxylin-eosin,safranin-O,toluidine blue and immunohistochemistry of collagen type Ⅱ.The microcarriers were seeded with rabbit bone mesenchymal stem cells(BMSCs) and cocultured with Rotary Cell Culture System(Rotary Cell Culture System,RCCS TM).[Results]The cartilage particles had fiocculus apparence.There were numerous villus on the surface of these cartilage micelles,which were stained positive with the immunohistochemistry of collagen type Ⅱ.The inner part of these cartilage micelles were stained positively with safranin-O and toluidine blue.After coated with BMSCs and cultured in the RCCSTM,the cells grew well on the surface of the cartilage micelles and the latter could be disperse again after blowed with pipette.[Conclusion]The cartilage micelles,which have large surface area and good boicompatibility,is a new kind of microcarrier for injectable tissue engineering cartilage.

Objective To study the expressions of phosphatese and tensin homolog deletedin chromosom ten (PTEN),Fas/FasL system and matrix metalloproteinnases-2 (MMP-2) in human gastric cancer.Methods Seventy-five cases of gastric carcinoma were selected from paraffin wax embodied specimens with full clinicopathological data,and another 15 cases of normal gastric mucosa specimens were selected as the control group.SP immunohistochemistry was used to measure the expressions of PTEN,Fas/FasL and MMP-2 in them.The data was statistically analyzed by ?2 test and relative analysis.Results The expressions of PTEN,Fas/FasL and MMP-2 were correlated with the lymphatic metastasis,degree of infiltration,clinical TMN stage and pathological histological differentiated degree of gastric cancer (P

AIM: To investigate the effects of ErbB2 overexpression on growth and invasiveness in cultured MCF-7 cell line. METHODS: Retrovirus containing ErbB2 gene was transfected into MCF-7 cells and ErbB2 expression was detected by Western blotting. Proliferation and invasive assays were carried out. Cells overexpressed ErbB2 and its control, AP2, were used in the experiment. RESULTS: ErbB2 was overexpressed in MCF-7 cells after transfection. In vitro, cells overexpressed ErbB2 showed highly proliferated and highly invasive characteristics compared to the control cells. CONCLUSION: Overexpression of ErbB2 promotes cell proliferation and enhances invasiveness in MCF-7 cells. Inhibition of signaling induced by ErbB2 might be a novel strategy for the therapeutics of cancer with ErbB2 overexpression.

Adult ; Carcinosarcoma ; pathology ; Female ; Heart Neoplasms ; pathology ; Humans ; Lung Neoplasms ; pathology ; Myocardium ; pathology