Objective:To study biomedical engineers’ working function in medical device adverse events monitoring.Methods: According to the core function of biomedical engineering discipline and the related theory of adverse events, we analyzed the complexity and difficulty of medical device adverse event monitoring, pointed out the major jobs of biomedical engineers and combined with the medical device maintenance case analysis.Results: The risk management of medical device is the working focus of biomedical engineers. Biomedical engineers have professional advantages in medical device adverse event monitoring.Conclusions: Based on discipline advantages and working core functions, the biomedical engineers can report high quality medical device adverse events and analyze and deal with them in time.

Objective To evaluate the diagnostic value of liver function for cases of laparoscopic common bile duct exploration indications to identify the exploration negative and positive.Methods Grouped the 270 cases of laparoscopic common bile duct exploration according to the negative and positive exploration,analyzed differences between groups,analyzed diagnostic value of every index,and established scoring system and evaluate the diagnostic value.Results The liver function index ALT(P =0.003),AST (P =0.039),ALP(P ＜ 0.001),GGT (P ＜ 0.001),TB (P =0.031),DB (P =0.003),gender (P =0.002),ultrasound results (P =0.001) had differences between the groups.The best cutoff value index of liver function:ALT (33.5 U/L),AST (38.5 U/L) and ALP (87.5 U/L),GGT (34 U/L),TB (16.00 U mol/L),DB (4.00 U mol/L);The diagnostic value and the 95％ confidence interval for each indicator:ALT 0.649 (0.563 ～ 0.736),0.600 (0.510 ～ 0.691) AST,ALP 0.673 (0.596 ～ 0.750),GGT 0.674 (0.592 ～ 0.755),TB (0.489 ～ 0.656),0.572 DB 0.652 (0.568 ～ 0.737).The highest diagnostic value was value scoring system diagnosis,the diagnostic value of the best cutoff value and 95％ confidence interval were 0.741 (0.662 ～0.820).The positive predictive value was 70.2％,negative predictive value was 65.9％.Conclusion The scoring system with liver function,gender and ultrasound findings established chnical reference value for identifying those who do not need the common bile duct exploration from cases of laparoscopic common bile duct exploration indications.

Objective To investigate the effects of mesalazine combined with Xianglian pills on cytokines and immunocytes in ulcerative colitis. Methods A total of 86 patients with ulcerative colitis from our hospital were collected and randomly divided into experimental group and control group with 43 cases in each group.Patients in the control group were treated by mesalazine, patients in the experimental group were treated by mesalazine combined with Xianglian pills treatment.The cytokines and immunocytes levels and efficacy between two groups were compared.Results After treatment, the clinical effective rate of the control group 69.77% was lower than the experimental group 88.37%, with statistical significance ( P <0.05 );compared with the control group, the TNF-αlevel of the experimental group was lower than the control group, IL-2, IL-4 and IL-10 levels were higher than the control group;the serum TFF1 and TFF3 levels were higher than the control group;CD3 +, CD4 +/CD8 +and NK cells levels were higher than the control group, the level of CD8 +was lower than the control group, with statistical significance ( P<0.05 ) .Conclusion Mesalazine combined with Xianglian pills in the treatment of patients with ulcerative colitis could reduce the inflammatory reactions and improve the clinical efficacy, with lower adverse reactions.

Objective:To analyze relationship between early intervention treatment and long-term prognosis in pa-tients with acute non-ST segment elevation myocardial infarction (NSTEMI).Methods:A total of 948 acute NSTE-MI patients were enrolled.According to NSTEMI intervention treatment timing,they were divided into early inter-vention group (received intervention treatment within 48h n=411,)and late intervention group (received interven-tion treatment after48h,n=537).According to TIMI risk score,the two groups were further divided into low risk subgroup,medium risk subgroup and high risk subgroup,the clinic long-term outcome was compared among all groups.Results:Compared with late intervention group,during one year follow-up,there were significant reduction in mortality during hospitalization (4.8% vs.2.2%)and incidence rate of major adverse cardiovascular events (MACE,13.4% vs.10.0%)in early intervention group,P <0.01 both;in early intervention group,mortality dur-ing hospitalization of low and medium risk patients was significantly lower than that of high risk patients (3.3% vs. 8.9%,P <0.01).Multi-factor regression analysis indicated that aged,high Killip class,reduced left ventricular e-jection fraction,high TIMI risk score and late intervention treatment were independent risk factors for clinic long-term outcome in NSTEMI patients (OR=1.027~2.079,P <0.05 or <0.01).Conclusion:Early intervention treat-ment can improve prognosis in NSTEMI patients.

Objective To discuss the influence of Ginkgo biloba extract on platelet aggregation of the patients with acute cerebral infarction.Methods 102 patients with acute cerebral infarction were selected and randomly divided into the control group and the observation group,each group had 51cases.The patients of the control group were given the conventional drug therapy,while the observation group were given the Ginkgo biloba extract treatment on the basis of the treatment of the control group.Results The platelet aggregation of the two groups after treatment made significant difference compared with that before treatment(P ＜ 0.05).The platelet aggregation caused by ADP was (65.1 ± 8.1) ％ and was obviously lower than that of the control group (t =5.732,P ＜ 0.05).The platelet aggregation caused by AA was (30.1 ± 5.2) ％ and was obviously lower than that of the control group (t =6.897,P ＜0.05).The platelet aggregation caused by PAF was (42.1 ± 6.3) ％ and was obviously lower than that of the control group (t =6.013,P ＜ 0.05).The neurological function of the two groups after treatment made significant difference compared with that before treatment (P ＜ 0.05).The socres of the observation groupafter treatment was (5.98 ±1.09),which was obviously lower than that of the control group (t =5.469,P ＜ 0.05).Conclusion Ginkgo biloba extract could significantly reduce the platelet aggregation of the patients with acute cerebral infarction and deserved promotion.

Objective To study the effects of β-aescine sodium plus oxiracetam on plasma homocysteine (Hcy) and monocyte chemotactic factor(MCP-1) protein in patients with acute cerebral infarction.Methods 117 patients with acute cerebral infarction were randomly divided into the two groups,the observation group (n =60 cases) and the control group (n =57 cases).The patients in the control group were treated with the conventional treatment,while the patients in the observation group were treated with joint treatment ofβ-aescine sodium plus oxiracetam.They were treated for 14 days.Plasma Hcy and MCP-1 were detected.Results The total efficicies were 95.0％ in the observation group and 84.5％ in the control group.There was a significant difference between two groups (x2 =5.801,P ＜0.05).Plasma Hcy and MCP-1 were decreased after treatment (t =9.551,4.296,2.001,21.070,P ＜ 0.05,P ＜0.01).Plasma Hcy and MCP-1 in the observation group were lower than these in the control group (t =4.997,25.276,all P ＜ 0.05).Conclusion β-aescine sodium plus oxiracetam can decrease plasma Hcy and MCP-1 in patients with acute cerebral infarction.

3 grades on the corresponding areas with compare to normal person, the positive rate of BEAM ia patient with CVD was 90.4%, more than that of the result of routine EEG(73%).

Many controversies and unanswered questions surround AIS(adolescent idiopathic scoliosis),the most difficult one is the absence of information about its aetiopathogenesis.Although bracing has been regarded as the standard of care for patients at a high risk of progression,it has never been subjected to rigorous assessment of either its efficacy or effectiveness.With respect to surgical management,although technology has greatly increased the safety with which we can correct spinal deformity and preserve spinal balance,long-term results of these changing methods of management are absent.Surgery can reduce deformity and prevent further progression;thereby decreasing the risk of future cardiopulmonary compromise,but its role in the prevention of other negative long-term effects of scoliosis is not clear.In this paper we discuss present notions about aetiopathogenesis,natural history,non-operative treatment,and surgery.

Objective To discuss the application of improved agarose electrophoresis for detecting bone alkaline phosphatase(BALP) isoenzymes in the diagnosis of metastasis in prostate carcinoma(PCa).Methods Serum ALP isoenzymes in 50 persons undergoing physical examination and 163 cases of PCa were detected by the improved agarose electrophoresis after treating serum by neuraminidase.Results (1)The resolution of liver and bone ALP by the common agarose gel electrophoresis was lower,and which was increased by the modified agarose electrophoresis.(2)Total ALP and BALP in the PCa group were higher than those in the control group;total ALP and BALP activity in the PCa bone metastasis group were higher than those in the control group and non-metastasis group(P<0.05),there were no statistical difference in BALP and total ALP between the non-bone metastasis group and control group(P>0.05).BALP and total ALP in bone metastasis of prostate carcinoma were higher than no bone metastasis.Conclusion Bone ALP has a certain correlation with PCa bone metastasis,also between bone ALP and bone metastasis of carcinoma.After treating serum by neuraminidase,adopting the improved agarose gel electrophoresis for separating ALP isozymes contributes to the clinical auxiliary diagnosis of PCa bone metastasis.

Hp phenotypes were determined by polyacrylamide disc-electrophoresis in sera from 555 individuals of Han population in Kunming. HP phenotype frequencies were simillar to that of Shanghia, Quandong Han Population and the other six phenotypes (1-p,2-1F, F K etc) could be detected in Kuming population by the same method.