Customized management based on chemotherapy initiated a new era in the treatment of retinoblastoma(RB).Many domestic ophthalmic centers are making beneficial attempts in this domain.However,the understanding of the trend needs to be improved throughout the country.In this article,a brief comment in five aspects is done in order to break the obsolete opinion and generalize the international classification of RB;correct some misunderstandings;promote an awareness campaign for early diagnosis;enhance the multi-center cooperation to improve the quality of clinical studies and start clinical and experimental research on RB.

Objective: To establish a method of HPLC for determination of chlorogenic acid and baicalin in Yinhuang Oral Liquid (Flos lonicerae, Radix Scutellariae). Methods: LUNA C18(2) column was used. The acetonitrile 0.1% phosphoric acid solution was used as the mobile phase. The flow rate was 1.0mL?min -1 . The detection wavelength was set as 318nm. Results: For chlorogenic acid, the linear range was 0.2568 ～ 2.0544 ?g, and the average recovery rate was 97.7% with RSD =0.8%. For baicalin, the linear range was 0.9896 ～7.9168?g, and the average recovery rate was 98.0% with RSD =0.9%. Conclusion: The method is simple, reliable, accurate and can be applied to the quality control of the preparation.

Female ; Fertility ; drug effects ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; drug therapy ; physiopathology ; Pregnancy ; Protein Kinase Inhibitors ; pharmacology ; therapeutic use

Objective To observe the effect and value of erythropoietin (EPO) with monosialotetrahexosylganglioside (GM 1) on hypoxic ischemic encephalopathy (HIE) of newborn.Methods Seventy cases of newborn with HIE were selected and divided into research group and control group based on different treatment methods,35 cases of each group.Research group were given EPO and GM 1:newborn were given subcutaneous injection of 300 U/(kg · w) EPO,3 times a week,with duration of two weeks;daily dose of GM1 was 20 mg,with intravenous injection for consecutive 2 weeks.Control group were given separate GM1:newborn were given GM1 intravenous injection,with daily dose of 20 mg for consecutive 2 weeks.Neonatal behavioral neurological assessment (NBNA) were performed on all newborn patients at the 14th day after born.At the 10th months after born,Gesell Scale and the Bayley Scales of Infant Development were given to all patients.Results Total effective rate of research group was 97.14％ (34/35),and 82.86％ (29/35) for control group,the difference was statistically significant (x2=3.97,P＜0.05).At the 14th day after born,the behavior ability,passive muscle tension,active tension,primitive reflexes and general assessment scores of the research group were (10.20± 1.67) points,(8.28 ± 1.60) points,(8.11 ± 1.51) points,(4.57 ± 1.97) points and (6.12 ± 1.46) points,of the control group were (9.32 ± 1.51) points,(7.33 ± 1.54) points,(7.14± 0.98) points,(3.46± 1.58) points and (5.05 ± 1.35),the differences were statistically significant (t =2.31,2.53,3.19,2.60,3.18;P＜0.05).At the 10 months after born,the DQ scores of big sports energy district,fine motor energy district,language ability district,personal and social adaptation district and social energy district of research group were (90.01 ± 7.76) points,(90.32± 6.77) points,(93.03 ± 6.28) points,(94.88 ± 5.19) points and (92.87±7.36) points,of control group were (84.91 ± 6.51) points,(86.92 ± 6.56) points,(88.13 ± 5.85)points,(88.87±6.14) points and (88.04±7.03),the differences were statistically significant (t =2.98,2.13,3.38,4.42,2.81;P ＜ 0.05).At the 10 months after born,the Mental developmental index (MDI) and Psychomotor development index(PDI) of research group were (92.87±7.05) points and (94.45±5.78) points,of control group were (89.23 ± 6.89) points and (90.26 ± 6.03) points,the differences between the two groups were statistically significant(t =2.18,2.97;P＜0.05).Conclusion EPO with GM 1 on the treatment of HIE is of high clinical efficiency.In addition,it promotes early recovery of neurological symptoms in newborn with HIE,with long-term effects on the nervous system of children.

Glioma is the most common primary malignant tumor in the brain.Although through standardized treatment,including the largest range of surgical resection and subsequent radiotherapy and chemotherapy,the morbidity and mortality is still high,so we need a new treatment.The oncolytic virus antitumor concept was mentioned in the early 20th century,which is a kind of antitumor virus,people found that cancer patients infected with certain viruses,the tumor was gradually disappeared.With the development of Molecular Biology,Immunology,Virology and Genetic Engineering,oncolytic virus becomes a new method of tumors treatment,which attracts more and more researchers' attention,so we made an overview in the antitumor principle of oncolytic virus and its clinical application in the treatment of glioma.

The incidence of invasive fungal infection in critically ill patients is increasing year by year. Its clinical manifestation lacks specificity which is difficult for early diagnosis. It′s hard to identify inva-sive fungal infection with fungal colonization in clinical practice. We need to find out the way to distinguish them.

Objective To study the value of multiphasic contrast-enhanced 3.0T MRI in the preoperative assessment of resectability in pancreatic cancer.Methods 38 patients with pancreatic cancer proved by operation and pathology were performed with multiphasic contrast-enhanced imaging at 3.0T MRI.The resectability of lesions was judged according to the status of vascular and adjacent organ involvement,lymphadenopathy and distant metastases on MRI images,which were compared with the results of operation.Results Of 38 pancreatic cancer,32 lesions located in the head,4 tumors in the body and 2 lesions in the tail of pancreas.MRI predicted that 1 9 tumors were resectable in which 1 7 lesions were successful resection,the accuracy of the positive predictive value for resectability was 89.5%.19 lesions were predicted to be unresectable by MRI,which were verified by surgery,the positive predictive value for un-resectability was 100%.The primary causes of unresectability contained peripancreatic main vessels involvement,liver metastasis, lymphadenopathy and peritoneal metastasis.Conclusion MRI multiphasic contrast-enhanced imaging has important value in preoper-ative resectability assessment of pancreatic cancer,which provides an useful reference for clinic to select appropriate treatment options.

Acute poisoning occurs in age of children and threatens children's life.In developed country,monitoring network about children's poisoning showed related risk factors,which helped preventing and managing poisoning quickly.The fatality rate of children's poisoning is high in China.There is no monitoring network in our country.We summarized the influencing factors and treatment of acute poisoning in children.

The course of audiology is both important and difficult to the undergraduate education of otolaryngology.Through a series of reforms in teaching contents and methods of audiology,the students'effect of study were greatlyimproved,and thus these reforms were generally appreciated by both teachers and students. In conclusion, the act of theteaching reform not only advanced the students' learning enthusiasm and gumption, but also helps the development andexercise in their clinical thinking ability.

Combined with the routine work of preventing and treating diseases, the construction of a clean and honest administration in stomatological hospital would be beneficial to raise the administrative staff's awareness of the constructive characteristics of a clean and honest administration in their work belief and methods to enhance the work initiative and effectiveness.