Objective:To research the epidemic situation of fatty liver in ethnic minorities' regions in Guangxi.Methods:Total 24076 persons who were in ethnic minorities' regions in Guangxi received physical examination and laboratory test.A contrastive analysis of body mass index(BMI),blood pressure(BP),blood lipids,blood glucose and liver function was carried out between fatty liver group and non-fatty liver group.Results:The total number of fatty liver was 3816 cases,with the ratio was 15.85% among them.The ratio of males was 17.57%,and the ratio of females was 11.33%,showing the prevalence of fatty liver in males was significantly higher than that in females.The prevalence of fatty liver increased with age.The morbidities of obesity,hyperlipidemia,hypertention,and diabetes mellitus in the fatty liver group were significant higher than in non-fatty liver group.Conclusion:Obesity,hyperlipidemia,hypertention,and diabetes mellitus may be independent risk factors of fatty liver.The mildly to moderately abnormal hepatic functions could be found in patients with fatty liver.Losing the body weight,controling the hyperlipidemia and maintaining normal glucose and blood pressure are important measures to prevent the fatty liver.

OBJECTIVE:To compare the effects of omeprazole and esomeprazole,two kinds of proton pump inhibitors,on clopidogrel platelet inhibition following cardiac stents implantation.METHODS:Totally 180 patients with coronary artery disease underwent percutaneous coronary intervention (PCI) at the Zhujiang Hospital of Southern Medical University from June 2008 to May 2009 were selected,including 83 males and 97 females.All patients were randomly divided into 3 groups,omeprazole + clopidogrel + aspirin group (OCA group,receiving omerprazole 20 mg/d),esomeprazole+clopidogrel+aspirin group (ECA group,receiving esomeprazole 10 mg/d),and control group (No proton pump inhibitor),with 60 patients in each group.In addition,all patients received a 300 mg clopidogrel and 0.1 g aspirin prior to PCI,and received 75 mg/d clopidogrel and 100 mg/d aspirin treatment for 1 week after PCI.Blood samples from patients were obtained from cubital vein before and at 1 week after adminstration,respectively.The vasodilator stimulated phosphoprotein phosphorylation state and platelet reactivity index (PRI) were calculated by flow cytometric assay.RESULTS:The PRI had no significant difference before administration (P>0.05),which was obviously decreased at 1 week after administration (P<0.05),especially lowest in the control and ECA groups (P<0.05).However,the PRI differences between the control and the ECA group had no significant (P>0.05).CONCLUSION:The administration of omeprazole rather than esomeprazole is associated with impaired clopidogrel platelet inhibition.Esomeprazole can be used as one of the preferred proton pump inhibitor in curing gastrointestinal bleeding caused by anti-platelet therapy following cardiac stents implantation.

Objective To study the role of Th1/Th2 cytokine profile in the pathogenesis of recurrent genital herpes (RGH), and to find out the relationship between Th1/Th2 cytokines. Methods A two－ colour immunofluorescent staining of cell surface antigen and intracellular cytokines (IL－ 2、 IL－ 10、 IL－ 12、 IFN－ γ and TNF－ α ) in CD3＋ T－ lymphocytes of 20 patients with RGH with flow cytometric analysis were performed. Results Compared to controls, patients with RGH showed a decreased number of CD3＋ T cells（ P0.05） . Conclusions RGH patients seem to have a predominance of Th2 cytokine profile, which may play an important role in the pathogenesis of RGH.

Based on the theory of cancer stem cells (CSCs),people have been searching for the treatments of malignant cancers.Gastric cancer side population cells (SP) have the characteristics of CSCs.Searching for the molecular targeted therapy strategy of gastric cancer which embarks from the gastric cancer SP and is based on the theory of CSCs provides a new direction for the treatment,early diagnosis,therapeutic effect and prognosis of gastric cancer.

Objective To observe the clinical curative effect of sijunzi decoction composite with shenqi pills in the treatment of spleen and kidney yang deficiency syndrome in patients with primary hypothyroidism(hypothyroid-ism).Methods 62 spleen kidney yang deficiency patients with hypothyroidism were randomly divided into 30 cases in the control group and 32 cases in the treatment group.Patients in the control group were given L-thyroxine tablets orally,once a day;patients in the treatment group were given sijunzi decoction combined with shenqi pills for decoc-tion,daily 1 agent,3 times a day orally,on the basis of the control treatment group.Two groups treatment cycle were 4 months,and the clinical efficacy of the two groups were observed.Results The treatment group total effective rate was 96.9%,which was higher than that in the control group 80.0%(χ2 =4.402,P<0.05);before and after treat-ment,TCMsyndrome scores were significantly decreased in the two groups (t=21.40,25.40,all P<0.01)and treatment group decreased more significantly(t=4.30,P<0.01 ).Before and after treatment,TSH,FT3,FT4 in the two groups were significantly improved (control group:t=5.31,1.14,4.13,treatment group:t=6.27,1.85,6.08,all P<0.01),and the degree of improvement in treatment group was more obvious compared with the control group (t=1.33,0.67,278,all P<0.05).Conclusion Sijunzi decoction and shenqi pills can significantly improve the clinical symptoms of primary hypothyroidism of spleen-kidney yang deficiency type in addition to thyroid function and blood lipid,indicating that this method is capable of achieving satisfactory clinical effects in treating primary hypothyroidism of spleen-kidney yang deficiency type.

Objective To find out the difference in Multi-channel Cochlear mapping between SPrint speech processor and ESPrit speech processor (ESPrit 3G) for better guidance of the mapping.Methods Nine cases of total deafness patients (aged 2-54 years old) using SPrint changed to using ESPrit 3G after 6 to 24 months. The threshold (T-L) of electro-audiogram using different speech processor, comfortable level, sound field audiometry in various ESPrit 3G programs and questionnaire results were compared and analyzed statistically.Results Using various speech processor programs, four patients(The first group) felt satisfied with hearing effects. There was no difference comparing with SPrint. There was significantly different in T-L and C-L acquired from five patients(The second group) with two speech processors (P0.05). The results of sound field audiometry showed significant difference in the first group and the second group using programs from SPrint(P

It is important to analyze the epidermal growth factor receptor ( EGFR) mutation before makingstrategyonnon-small cell lung cancer ( NSCLC) patients scheduled to EGFR tyrosine kinase inhibitor ( TKI) therapy .Digital PCR is a new generation of molecular diagnostic technique that provides ultra-highersensitive, specific and absolute nucleic acid quantification based on its unique principle.The application of digital PCR indetecting circulate tumor DNA can be the truly tumorliquid biopsy, helps to acquire the accurate EGFR mutation status from peripheral blood and screen out the most appropriate patients for TKI therapy.This breakthrough technology will also contribute to tumor surveillance and drug resistance monitoring.

Objective To study the role of Th1/Th2 cytokine profile in the pathogenesis of recurrent genital herpes (RGH), and to find out the relationship between Th1/Th2 cytokines. Methods A two-colour immunofluorescent staining of cell surface antigen and intracellular cytokines (IL-2、 IL-10、 IL-12、 IFN－? and TNF－? ) in CD3＋ T-lymphocytes of 20 patients with RGH with flow cytometric analysis were performed. Results Compared to controls, patients with RGH showed a decreased number of CD3＋ T cells（ P0.05） . Conclusions RGH patients seem to have a predominance of Th2 cytokine profile, which may play an important role in the pathogenesis of RGH.

Objective To investigate clinical value of D-dimer in tumor. Methods 377 cases of diseases and 50 cases of normal control were collected D-dimer in all cases was determined by gold standard method. Results In 377 tumor patients, plasma D-dimer levels in the primary therapy group were higher than the normal adult group (P <0.01) ,plasma D-dimer levels in the catabetic group were obviously decreased. Conclusions D-dimer examina-tion could provide evidence for clinical diagnosis,treatment and predictor in tumor. It could be used as useful index for observing effectiveness and early stage diagnosis in diseases with malignant neoplasm.

Antibodies, Viral ; analysis ; Cerebrospinal Fluid ; virology ; Child ; Child, Preschool ; Feces ; virology ; Genotype ; Humans ; Infant ; Meningoencephalitis ; diagnosis ; virology ; Parechovirus ; classification ; genetics ; isolation & purification ; Picornaviridae Infections ; diagnosis ; epidemiology ; virology ; RNA, Viral ; genetics ; Respiratory Tract Infections ; diagnosis ; virology ; Sepsis ; diagnosis ; virology ; Sequence Analysis, DNA