Objective To investigate the expression and significance of ERα (estrogen receptorα),ERβ(estrogen receptorβ),PR,and Bcl-2 of endometrial polyps.Methods 50 cases of endometrial polyp patients were studied.And 45 cases of endometrial normal subjects were selected as the control group.The enzyme-linked immunosorbent assay was used to detected the FSH,LH,E2,P,T and PRL six levels of the two groups.And endometrial ERα two groups of patients,ERβ,PR and Bcl-2 expression was studied.Results The FSH,LH,E2,P,T and PRL six levels of the two groups were no significant difference(P ＞0.05).Polyps in patients with proliferative phase of ERα,ERβ expression levels of the normal group had no significant difference (P ＞ 0.05),the expression level of PR(0.47 ± 0.02) point was significantly lower than that of the normal group(0.53 ± 0.02) point (t =10.383,P =0.000),Bcl-2 expression levels(0.53 ± 0.04) point was significantly higher than that of the normal group (0.49 ± 0.02) point (t =4.322,P =0.000).Polyps in patients with secretory phase of ERα,Bcl-2 expression levels (0.46 ± 0.07;0.43 ±0.04)point were significantly higher than that of the normal group (0.37 ± 0.05 ;0.39 ± 0.03) point (t =5.007,P =0.000; t =3.834,P =0.000),the expression level of PR (0.42 ± 0.02) point was significantly lower than that of the normal group (0.46 ± 0.01)point(t =8.486,P =0.000),there was no significant difference in expression levels between the two groups ERβ(P ＞0.05).Between the two groups displayed,ERα,PR proliferative phase of the normal group and the polyp group,the expression levels of Bcl-2 were significantly higher than that of the secretory phase (P ＜ 0.05).Conclusion The increase of the ERα,Bcl-2 expression levels,and the reduction of the level of PR expression in patients with endometrial polyps are closely related.

Objective To investigate the relationship between the ultrasonic sign and expression of HMGB1 ,VEGF in serum of hepatocellular carcinoma patients .Methods Doppler ultrasound was used to inspect the size of the tumor and to analyze the typing and flow classification .The ELISA was used to check the HMGB1 and VEGF in serum .Results The expression level of HMGB1 in nodular and massive group was higher than that in small modelgroup (53 .5 ± 4 .3) ng/mL .The expression level of HMGB1 in massive group(102 .9 ± 9 .7)ng/mL was higher than that in nodular group(76 .0 ± 6 .2) ng/mL(P<0 .05) .The VEGF among three groups had no difference(P>0 .05) .With the increase of flow classification ,the levels of HMGB1 and VEGF also increased(P<0 .05) .Conclusion The HMGB1 in serum has some connection with morphology types .The HMGB1 and VEGF in serum increase with the flow classification .

ObjectiveTo observe the turnover of impaired glucose tolerance(IGT)patients intervened with different measures.MethodsIGT 158 patients found by physical examination in the community residents were randomly divided into health education group,Chinese medicine group,and western medicine group,and treated with health education,traditional Chinese medicine and western medicine respectively.The fasting blood glucose,oral glucose after 2hour blood glucose (2hPG),serum lipid,glycosylated hemoglobin index were observed.ResultsThe efficiency of patients with IGT was 48.0％,70.3％ and 75.0％ in health education group,Chinese medicine and western medicine respectively.There was significant difference of therapeutic effect between the western medicine group and health education group (x2=7.96,P＜0.05),and between the traditional Chinese medicine group and health education group (x2=5.46,P＜0.05),while there was no significant difference between the traditional Chinese medicine group and Western medicine group (x2 =2.31,P＞0.05).ConclusionTraditional Chinese medicine and Western Medicine both have good effects on patients with IGT.But due to its good tolerability and few side effect,TCM may be more easily accepted by patients.

Erythropoietin (EPO),a glycoprotein hormone,plays an important role in erythropoiesis in early days.Recently,EPO is also considered to have protective effects against neuroprotection,bronchopulmonary dysplasia and neonatal necrotizing enterocolitis.EPO has been widely used in premature clinical practice and provide some prospects in premature-related diseases.

Objective To investigate the effect of butylphthalide combined with nimodipine in the treatment of vascular cognitive impairment.Methods 160 patients with vascular cognitive impairment were divided into the control group and the observation group according to treatment methods,80 cases in each group.The control group was treated with nimodipine,and the observation group was given butylphthalide combined with nimodipine treatment.The therapeutic effect and cognitive function were compared.Results The obvious effective rate of the observation group was 58.75 ％ (47/80),which was significantly higher than that of control group 45 ％ (36/80) (P =0.03).After treatment,MoCA score of the observation group was (24.83 ± 9.48),which was significantly higher than that of the control group(21.64 ±9.52) (P =0.04).ADL score of the observation group was(58.31 ± 11.27),which was significantly higher than(53.28 ± 10.32) of the control group (P =0.04).After treatment,directional force,visual spatial and executive function,delayed memory and attention of the observation group were higher than those of the control group (P =0.03,0.02,0.04,0.02).Conclusion Butylphthalide combined with nimodipine in the treatment of patients with vascular cognitive impairment has good effect.

Objective To study effect of total hip replacement and artificial head of femur replacement in patients with failed femoral neck fracture.Methods 62 cases with failure of the conservative treatment or fixed steel femoral neck fracture were enrolled as research subjects.They were randomly divided into the two groups,the control group (n =31) and the observation group (n =31).They were operated through hemiarthroplasty in the control group,while they were operated through total hip replacement in the observation group.The operative time,blood loss,drainage,hospital stay,hip function,VAS score and quality of life changes,early complications were observed.Results The operative time,blood loss,drainage,length of hospital stay were (87.4 ± 21.3) min,(209.6 ± 34.5) mL,(174.2 ±29.4)mL and (17.8 ±5.6)d in the control group and (104.2 ±33.7)min,(229.1 ±35.1)mL,(182.2 ± 30.5) mL and (18.2 ± 6.2)d in the observation group.The operative time in the observation group was significantly longer than that of the control group (t =4.927,P ＜ 0.05).The blood loss,drainage,length of hospital stay were no significant difference between the two groups (t =0.386,0.413,0.775,all P ＞ 0.05).The excellent rate of hip function was 83.9％ (26/31) in the control group and 96.8％ (30/31) in the observation group,the observation group was significantly higher (x2 =6.92,P ＜ 0.05).Score changes of VAS and quality of life were (23.4 ± 9.2) and (36.1 ± 11.2) in the control group and (35.1 ± 10.6) and (42.8 ± 12.6) in the observation group.Score changes of VAS and quality of life in the observation group were higher (t =6.032,3.924,all P ＜ 0.05).The early complications occurred in the control group was 25.8％ (8/31),which in the observation group was 9.8％ (3/31),the early complications in the observation group was significantly lower than that in the control group (x2 =13.64,P ＜0.01).Conclusion For patients in the conservative treatment or femoral neck fracture fixation failure or steel,the use of total hip replacement surgery was complicated,but it can significantly improve hip function,reduce pain,improve quality of life and reduce early complications.

Objective To study parecoxib sodium preemptive analgesia on agitation and inflammatory factors in patients with esophageal cancer.Methods 78 patients with esophageal cancer were randomly divided into two groups,the control group(n =39 cases) and the observation group(n =39 cases).The patients in observation group received parecoxib sodium preemptive analgesia,while the patients in the control group were given NS.Then,both two groups were given conventional anesthesia.Restlessness was observed in patients with grading and Remesay sedation score.Serum concentrations of interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured before anesthesia (T0),surgery (T1),6h after operation (T2),and 24h after operation (T3).Results Degree of agitation in the observation group was significandy lower than the control group (x2 =6.26,P ＜ 0.05).In the control group,irritability,sedation,sedation were 18 cases,20 cases,one case and those in the observation group were 6 cases,32 cases,one case.Higher satisfaction with sedation in the observation group(x2 =7.26,P ＜ 0.05),irritability rate in the observation group was lower than the control group (x2 =10.14,P ＜0.05).In the postoperative T1,T2,T3 moment,serum IL-6 level in the observation group was lower than the control group(t =3.172,4.001,2.702,all P ＜0.05),serum IL-10 level was higher in the observation group(t =3.112,2.624,3.092,all P ＜ 0.05).Conclusion Parecoxib sodium preemptive analgesia can decrease agitation and balance inflammatory factors in patients with esophageal cancer.

Objective To investigate the effect of applying the evidence-based nursing in elderly hypertensive cerebral hemorrhage patients with minimally invasive therapy.Methods 78 cases of hypertensive cerebral hemorrhage patients with minimally invasive treatment were recruited from May 2010 to May 2011.According to the conventional method of random numbers,they were divided into the evidencebased group and the conventional group with 39 cases in each group.The evidence-based group received evidence-based nursing,while the conventional group received conventional clinical nursing.The nursing effect of the two groups was observed.Results The satisfaction degree of the evidence-based group and conventional nursing group was respectively 94.9％ and 79.5 ％.There was statistically significant differences.The score of SDS,SAS and BI before treatment between two groups showed no significant difference,while it showed statistically significant differences after treatment between two groups.The complication rate of the evidence-based group and the conventional nursing group was respectively 10.2％ and 35.9％.There was statistically significant differences.Conclusions It is feasible to implement evidence-based nursing in the elderly hypertensive cerebral hemorrhage patients with minimally invasive therapy.It can effectively improve the patients' negative emotions,enhance daily living and quality of life.It is simple and can effectively reduce the incidence of complications.Thus,it is worthy of clinical application.

Neonatal infection is one of the important reasons for newborns mortality.The current diagnosis indicators of neonatal infection have differences in the sensitivity and specificity,respectively.In recent years,procalcitonin (PCT) is widely used in the diagnosis of various infectious diseases.Studies showed that the PCT had higher sensitivity and specificity in the early diagnosis of neonatal infection.Serum PCT level is associated with the severity of neonatal infection,the development and the prognosis of the disease.It can be used to evaluate the effect of treatment and the prognosis.During the period of neonatal,the serum PCT is not affected by the level of maternal and the acute inflammatory response which caused by injuries and asphyxia,and it is associated with the severity of newborn bacterial infection.PCT has special significance to the diagnosis of neonatal infection.