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0.05). After IL-1? was addied, densities of EGF, EGFR, TGF?R 1 were 224.00?31.59, 178.67?27.86 and 80.34?11.75 respectively in fibroblasts of normal skin; 128.75?18.31, 105.82?21.61 and 109.83?25.79 in fibroblasts of HS;113.01?24.71,93.34?30.71 and 118.75?19.27 in fibroblasts of keloid. Densities of EGF and EGFR in fibroblasts of normal skin was significantly higher than those in HS and keloid (P

Scientific research design includes specialty design and statistics design which can be subdivided into experimental design, clinical trial design and survey design. Usually, statistics textbooks introduce the core aspects of experimental design as the three key elements, the four principles and the design types, which run through the whole scientific research design and determine the overall success of the research. This article discusses the principle of randomization, which is one of the four principles, and focuses on the following two issues--the definition and function of randomization and the real life examples which go against the randomization principle, thereby demonstrating that strict adherence to the randomization principle leads to meaningful and valuable scientific research.

Acupuncture Points ; Acupuncture Therapy ; Adult ; Aged ; Calcaneus ; Fasciitis, Plantar ; therapy ; Female ; Humans ; Male ; Middle Aged ; Musculoskeletal Manipulations ; Pain, Intractable ; therapy ; Pelvis ; injuries

Actins ; metabolism ; Animals ; Antigens, CD ; metabolism ; Cadherins ; metabolism ; Carotid Artery Injuries ; metabolism ; pathology ; Endothelium, Vascular ; metabolism ; ultrastructure ; Fluorescent Antibody Technique ; Microscopy, Confocal ; Rats ; Troponin ; metabolism

The principles of balance, randomization, control and repetition, which are closely related, constitute the four principles of scientific research. The balance principle is the kernel of the four principles which runs through the other three. However, in scientific research, the balance principle is always overlooked. If the balance principle is not well performed, the research conclusion is easy to be denied, which may lead to the failure of the whole research. Therefore, it is essential to have a good command of the balance principle in scientific research. This article stresses the definition and function of the balance principle, the strategies and detailed measures to improve balance in scientific research, and the analysis of the common mistakes involving the use of the balance principle in scientific research.

Randomization is one of the four basic principles of research design. The meaning of randomization includes two aspects: one is to randomly select samples from the population, which is known as random sampling; the other is to randomly group all the samples, which is called randomized grouping. Randomized grouping can be subdivided into three categories: completely, stratified and dynamically randomized grouping. This article mainly introduces the steps of complete randomization, the definition of dynamic randomization and the realization of random sampling and grouping by SAS software.