Saireito, a 12-component Japanese herbal medicine, is used to treat immune-related diseases. We investigated the effects of oral administration of Saireito extract in a murine model of cardiac transplantation with fully mismatched allografts. Untreated recipients and those given water rejected their cardiac allografts acutely (median survival time [MST], 7 and 8 days, respectively), as did those treated with either 0.02 or 0.002 g/kg/day of Saireito extract (MST, 7 days in both groups). Recipients given 0.2 g/kg/day of Saireito extract had only moderate prolongation of allograft survival (MST, 41 days). However, all transplant recipients given 2 g/kg/day of Saireito extract had significant prolongation of allograft survival (MST>100 days). None of the single crude drug extracts of Saireito prolonged allograft survival, suggesting that its effects require administration of the combination agent. In mixed leukocyte cultures, proliferation of splenocytes from Saireito-treated CBA recipients was markedly suppressed compared with that of splenocytes from untreated mice, and interferon-γ production was significantly reduced. In flow cytometry experiment, the population of CD 4⁺CD 25⁺FOXP 3⁺cells was increased in the spleens of Saireito-treated CBA recipients compared with the spleens of naïve CBA mice or untreated CBA recipients. Thus, in our model, Saireito treatment induced hyporesponsiveness to cardiac allografts in a dose-dependent manner, and the combination of the components is essential for this effect.

This paper mainly introduces the origin and development of the slit-lamp microscope, the basic structure, working principle and test methods, focuses on diffuse illumination, direct focal illumination, indirect illumination, retro illumination, zone of specular reflection and slit-lamp filter used in the optical inspection, to provide the reference for clinical general optometry practitioners and using slit-lamp microscope widely and standardized.
Lighting ; instrumentation ; Ophthalmology ; instrumentation

China ; Electrocardiography ; trends

Objective To compare the prevention effect of atrial fibrillation recurrence in hypertensive patients by telmisartan versus nifedipine.Methods Ninety-eight cases of hypertensive with paroxysmal atrial fibrillation patients were enrolled and divided into telmisartan group and nifedipine group with 49 cases each by random digits table method.Telmisartan group was given telmisartan 80 mg/d,nifedipine group was given nifedipine 30 mg/d.Dose of the drug needed to be adjusted according to individual condition until achieving the target.Followed-up for 18 months.Observed two groups of recurrence of atrial fibrillation and the recurrence time for the first time,recorded before and after the treatment of cardiac parameters:including left atrial diameter (LAD),left ventricular end diastolic diameter(LVDD),left ventricular posterior wall thickness (LVPWT),interventricular septum thickness (IVST),left atrial volume index(LAVI) and left ventricular mass index(LVMI).Results The blood pressure after treatment in two groups was lower than that before treatment,there was statistically significant difference (P＜ 0.05),but there was no statistically significant difference between two groups (P ＞ 0.05).After treatment,the recurrence of atrial fibrillation,atrial fibrillation recurrence time for the first time in two groups had no statistical significance (P ＞ 0.05).But the incidence of persistent atrial fibrillation in telmisartan group was significantly lower than that in nifedipine group [4.1％ (2/49) vs.16.3％ (8/49)],there was statistically significant difference (P =0.045).The cardiac parameters between two groups before treatment had no significant difference (P ＞ 0.05).After treatment,the cardiac parameters in two groups were signifcantly reduced,there were statistically significant differences (P ＜ 0.05).Moreover,the LAD,LVPWT,LAVI and LVMI in telmisartan group after treatment were significantly lower than those in nifedipine group [(37.6 ± 2.9) mm vs.(38.9 ± 2.4) mm,(11.6 ± 1.0) mm vs.(12.0 ± 0.9) mm,(22.0 ± 3.6) ml/m2 vs.(23.9 ± 4.2)ml/m2,(120.4 ± 18.2) g/m2 vs.(129.5 ± 19.2) g/m2],there were statistically significant differences (P ＜ 0.05).Conclusions Nifedipine and telmisartan can effectively lower the blood pressure.But telmisartan is superior to preventing atrial fibrillation recurrences and developing in hypertensive with paroxysmal atrial fibrillation patients,promoting cardiac parameters and postponing myocardial remodeling.

Objective To investigate the effect of levocarnitine ane hemoperfusion on micro-inflammatory state of maintenance hemoeialysis patients. Methods Ninety-nine hemoeialysis patients were selectee as our subjects who hospitalizee from Jan. 2006 to Jan. 2013 in Provincial Hospital Affiliatee to Shaneong University ane were raneomly eivieee into A,B ane C groups. Thirty-three patients in A group were treatee with hemoperfusion combinee with L-carnitine therapy,33 cases in B group were appliee hemoperfusion ane 30 cases in C group were treatee with oreinary eialysis. The level of high sensitivity C reactionprotein( hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)were measuree at before treatment,1ane 6 months after treatment. Results The levels of IL-6 in A group at before treatment,1 ane 6 months were(( 77. 53 ±12. 64),(62. 17 ± 11. 09),(42. 76 ± 10. 22))ng/L respectively,ane those were((76. 13 ± 13. 46), (70. 07 ± 2. 54),(59. 35 ± 11. 21))ng/L respectively in B group ane((78. 10 ± 10. 74),(72. 81 ± 11. 73), (68. 11 ± 13. 53))ng/L respectively in C group. The eifferences were significant( F within group=11. 642,P<0. 01;F among groups=6. 341,P<0. 01,F interaction=18. 275,P<0. 01),ane at the same perioe,there was significant eifference between A ane B,C group( P <0. 05 ). The levels of TNF-α in A group at before treatment,1 ane 6 months were((43. 59 ± 9. 81),(32. 34 ± 8. 68),(25. 7 ± 71. 27))ng/L respectively,ane those were((44. 53 ± 8. 62),(39. 15 ± 9. 72),(34. 82 ± 7. 21))ng/L respectively in B group ane((42. 19 ± 6. 72),(38. 63 ± 7. 65),(36. 98 ± 5. 89))ng/L respectively in C group. The eifferences among 3 groups were significant( F within groups = 10. 630,P < 0. 01;F among groups = 6. 654,P < 0. 01;F interaction=18. 273,P<0. 01),ane at the same perioe,there was significant eifference between A ane B,C group( P<0. 05). The levels of hs-CRP in A group at before treatment,1 month ane 6 months were((9. 34 ± 1. 16), (7. 28 ± 1. 05)ane(5. 13 ± 0. 84))mg/L. Those were((9. 05 ± 1. 36),(7. 97 ± 1. 08),(5. 82 ± 1. 13))mg/L in B group ane((9. 25 ± 1. 34),(8. 83 ± 1. 12),(8. 56 ± 1. 08))mg/L in C group. The eifferences among three groups were significant( F within group=12. 002,P<0. 01;F among groups=6. 681,P<0. 01;F interaction=17. 753,P<0. 01). The level of IL-6,TNF-α,Hs-CRP in the same perioes among the three groups were significant( P<0. 05),ane at the same perioe,there was significant eifference between A ane B,C group ( P<0. 05). Conclusion L-carnitine can be effective in treating patients with maintenance hemoeialysis micro-inflammatory state ane the safety.

Luminal B breast cancer is a main subtype of breast cancer.Disease free survival and overall survival rate of patients with Luminal B subtype are lower than those of patients with Luminal A subtype.Luminal B breast cancer is often treated with chemotherapy and endocrine therapy,and anti-Her-2 therapy is also essential for Luminal B/Her-2 positive breast cancer,but the prognosis is still poor.With the increasing understanding of Luminal B breast cancer,new targets are developed and used for improving treatment effect.This review will describe the clinical and pathological features,factors affecting prognostic,common treatments and new therapeutic targets for Luminal B breast cancer.

Objective To compare the clinical effect of locking compression plate and anatomic plate fixation for Pilon fracture.Methods 68 patients with tibial Pilon fracture were selected and divided into two groups according to the random number table method,34 cases in each group,the observation group was given lock plus pressure plate fixation while the control group received anatomic plate for treatment,the clinically relevant indicators,treatment effect and occurrence of complications of the two groups were compared.Results The operation time of the observation group[(46.46 ±3.56)min],incision length[(5.25 ±0.75)cm],blood loss[(36.77 ±5.12)mL],plaster braking time[(13.23 ±1.77)d],fracture healing time [(12.42 ±1.43 )weeks],postoperative hospital stay [(9.89 ± 1.88)d]were less than or shorter than those of the control group [(68.76 ±4.45 )min,(12.78 ±1.54)cm, (84.75 ±8.65)mL,(20.30 ±2.43)d,(18.94 ±2.30)weeks,(15.67 ±2.64)d],the differences were statistically significant(t =6.834,9.455,7.488,6.591,7.033,8.210,all P <0.05).The excellent rate of the observation group was 94.12%,which was higher than 80.00% of the control group,the difference was statistically significant(χ2 =8.238,P <0.05).The postoperative complications occurred in the observation group was 5.88%,which was signifi-cantly increased to 17.65% in the control group,the difference was statistically significant(χ2 =7.657,P <0.05). Conclusion Compared with anatomical plate fixation,the locking compression fixation for Pilon fractures can shorten the healing time and reduce the incidence of complications,so it is safe and has significant advantages for the clinical application.

The origin of the word "male external genitals(Zongjin)" is coming from Inner Canon of Huangdi(Huangdi Nei Jing).This article synthesized the theories of past dynasties' doctors.It made a systemic statement on "male external genitals" in terms of the concept,physiological functions and the contacting effect with correlated meridian and vessels for the first time,so as to enrich the theory of visceral manifestations in TCM.Meanwhile,it also pointed out the significance and specific application of the theory that treating impotence based on "male external genitals",thereby provided a new view of treating "male external genitals" in TCM clinic.

OBJECTIVE:To probe into the perioperative use of drugs in epileptic patients.METHODS:By a retrospective analysis,the general condition,and drug use before,during and after operation of 117 epileptic inpatients in our hospital in 2006 was analyzed statistically.RESULTS:71(60.7%)epileptic patients before operation versus 83(70.9%)after operation received blood routine test and biochemical test.105(89.7%)received anti-epileptic drugs alone versus 12(10.3%)received combined drugs.The mean administration duration was 6.5 d for antibiotics versus 4.3 d for hormones.CONCLUSION:Great importance should be attached to the perioperative drug use in epileptic patients to standardize the use of antibiotics and hormones and follow the rational drug use principle so as to keep seizure under control and improve the quality of life for epileptic patients.

OBJECTIVE:To study the damage of drugs to the nervous system.METHODS:154cases of adverse reactions of nervous system drugs collected from1999to2003in our hospital were analyzed statistically.RESUTLS:ADR of nervous system accounted for14.27%of all the ADR cases in our hospital;there were18kinds of drugs involved in ADR,which in?cluded the anti-infection drugs,Chinese drugs preparation,cardiovascular system drugs,nervous system drugs,antipyretic analgesic etc.CONCLUSION:It is of great clinical significance to keep alert,to identify and avoid the adverse effects of drugs on nervous system.