BACKGROUND: There was no uniform criterion for muscle force sense test of the sagittal plane of the ankle joint.OBJECTIVE: To explore the test-retest reliability of the ankle muscle force sense (MFS) under different target force.METHODS: The target force of the muscle was 25%, 50% and 75% maximal voluntary isometric contraction to measure MFS.Consistency degree of the repeated measures was evaluated by intra-class correlation (ICC) and standard error of measurement(SEM).RESULTS AND CONCLUSION: Interclass correlation coefficients of variable errors and absolute errors in MFS were more than0.75, and SEM of them were lower. ICCs of constant error of them were less than 0.75, and SEMs of them were greater. Thetest-retest reliability for variable errors and absolute errors of MFS was better when the target force was smaller.

Pregnant women have a higher incidence rate of liver failure than women who are not pregnant,and liver failure is one of the ma-jor causes of death in pregnant women and parturients. Liver failure in pregnancy has complex symptoms and various complications and great-ly threatens the safety of mothers and infants. Accurate judgment of the prognosis of patients with liver failure plays an important role in guid-ing clinical work. This article introduces the influencing factors for the prognosis of patients with liver failure and the application of various models in pregnant women,in order to provide a reference for clinical work.

BACKGROUNDOveractive bladder (OAB) is a series of symptoms with high prevalence in elderly people. This study was conducted using the overactive bladder symptom score (OABSS) to evaluate the efficacy of solifenacin succinate for the treatment of OAB.

METHODSThis was a prospective, multicenter, single-arm, 12-week study that enrolled 241 OAB patients. The patients received 5-10 mg/day solifenacin. Changes in OABSS, symptoms from voiding diary, perception of bladder condition (PPBC) score, international prostate symptom score (IPSS) and quality of life (QOL) were evaluated at weeks 0, 4, and 12. The relationship between OABSS and PPBC score or parameters of voiding diary was also evaluated.

RESULTSAt baseline, the mean OABSS for all patients was 9.41 ± 2.40, and was reduced significantly at week 12 (-3.76 points; 61.21%, P < 0.0001). The OABSS subscore, PPBC score, IPSS, and QOL were also significantly reduced during the study (P < 0.0001). The overall incidence of adverse events was 19.91% (44 cases). The gastrointestinal system was the most commonly affected (11.31%). Around 5.88% of the cases had adverse events related to the genitourinary system. There was a strong correlation between OABSS and urinary symptoms that was recorded in the 3-day voiding dairy.

CONCLUSIONSWe showed that solifenacin was clinically effective for relieving OAB symptoms, considering the balance between efficacy, patients' well-being, and tolerability. OABSS integrates four OAB symptoms into a single score and can be a useful tool for research and clinical practice.

Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Muscarinic Antagonists ; therapeutic use ; Prospective Studies ; Quality of Life ; Quinuclidines ; therapeutic use ; Solifenacin Succinate ; Tetrahydroisoquinolines ; therapeutic use ; Treatment Outcome ; Urinary Bladder, Overactive ; drug therapy