Objective To evaluate the clinical efficacy and safety of Feitai capsule and antituberculosis agents in initially treatment of pulmonary tuberculosis patients. Methods:38 patients were administrated with Feitai capsule and antituberculosis agents for6 months. 15 patients were treated with placebo and anti-tuberculosis angents for 6 months. The changes were observed at 2 and 6 months after treatment, which were changes of sputum smear from positive to negative, lesions and cavities on radiography. Adverse drug reactions were observed during the whole treatment course. Results:The duration of change in sputum tuberculosis smear from positive to negative was short and the absorption rates of lesions and cavities on radiography were greater in the group of Feitai capsule than those of the control group. No evident adverse drug reaction was found. Conclusion: Feitai capsule is a kind of traditional Chinese medicine that accelerates the improvement of pulmonary tuberculosis patients at initial treatment stage as antituberculosis agent. It is effective and safe.

Objective To characterize the C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene in Xinjiang Uygur and Han nationality population.Methods The C677T polymorphism of MTHFR gene was detected by using PCR-restriction fragment length polymorphism (RFLP) in 134 Uygur and 166 Han nationality people.Results There were 3 MTHFR C677T genotypes,i.e.,CC,CT,and TT.A significant difference was observed in the frequency of CC,CT,and TT genotypes of MTHFR C677T polymorphism between Han and Uygur nationality people (21.7％,53.0％ and 25.3％ vs.16.4％,80.6％ and 2.96％,x2 =33.78,P ＜ 0.01).The frequency of CC,CT,and TT genotypes of MTHFR C677T polymorphism was 16.95％,79.67％,3.39％ respectively,in men of Uygur nationality,16.0％,81.33％,2.67％ respectively,in women of of Uygur nationality,25.8％,47.1％ and 27.1％ respectively in men of Han nationality,17.28％,59.26％ and 23.46％ respectively in women of Han nationality.There was no gender difference in the distribution of MTHFR C677T polymorphism in Han or Uygur nationality population (both P ＜ 0.05).Conclusions There is a significant difference between Uygur and Han nationality population,but no gender difference is observed,in the distribution of MTHFR C677T genotypes in Xinjiang Uygur Autonomous Region.

Objective To investigate the prevMenee depression in pregnant women during the first trimester in Chengdu.Methods Women in pregnancy for less than 12% weeks were enrolled in this study.They were investigated about depression condition by fulling out the EPDS and the self-compiled related factor forms.Results The pmvulence of depression was 39.1% at the pregnancy during the first trimester.The prevalence of depressive symptoms was significantly higher in women with induced abortion more than 2 times than those less than 2 times,also higher in women with unexpected pregnancy than those planned pregnancy. Conclusions The depression emotional disorder in the pregnancy women during the fast trimester is high.The doctorand nurse should pay close attention to those women to reduce depression.

BACKGROUND:It has been found that the compressive strength and flexural strength of nano-hydroxyapatite combined with light-cured resin matrix can neet the requirements of dental restorative materials. OBJECTIVE:To detect the cytotoxicity of nano-hydroxyapatite/composite resin, and to analyze its effects on the dental restoration. METHODS:In vitro test:passage 5 periodontal ligament fibroblast-like cel s and L-929 cel s suspensions were cultured in the 10%, 50%, 100%of nano-hydroxyapatite/composite resin extracts, respectively, and fresh maintenance medium functioned as negative control group. Absorbance values were detected within 7-day culture. In vivo repair test:57 cases with tooth defect were enrol ed containing 37 males and 20 females aged from 15 to 31 years old, and al were subjected to nano-hydroxyapatite/composite resin treatment. A 3-year fol ow-up was undergone to detect the completeness, marginal adaptation and color matching of the restoration, as wel as the periodontal probing depth, sulcus bleeding index, tooth mobility, dental plaque index, gingival crevicular fluid and aspartate aminotransferase level. RESULTS AND CONCLUSION:In vitro test results showed that the different concentrations of nano-hydroxyapatite/composite resin extracts had no effects on both periodontal ligament fibroblast-like cel s and L-929 cel s. In vivo repair test results found that after 3 years of fol ow-up, the periodontal probing depth, sulcus bleeding index, tooth mobility, dental plaque index, gingival crevicular fluid and aspartate aminotransferase level of patients were significantly decreased than those before repair (P<0.05), but the alkaline phosphatase level revealed no significant change (P>0.05). Unfortunately, three cases with incomplete restoration, four cases with color mismatching, and three cases with the inadaptable edge occurred. To conclude, the nano-hydroxyapatite/composite resin holds good biocompatibility and no cytotoxicity, which can maintain a good periodontal health condition in the dental restoration.

[Objective] To learn the bibliometric characteristics of Chinese ophthalmological papers indexed in SCI database from 2007 to 2011.[Methods] All the ophthalmological papers published in the source journals indexed in the SCI database from 2007 to 2011 were retrieved.The papers of first authors were manually selected for bibliometric analysis.[Results] The ophthalmological papers published by Chinese scholars as the first author were 478,482,698,791,and 1049 from 2007 to 2011 (total 3498).The five institutions that published papers in the most were Sun Yat-sen University,Capital University of Medical Sciences,Fudan University,Hong Kong Chinese University and Shanghai Jiaotong University.The papers were distributed in 625 journals.The top five journals the papers were published in were Molecular Vision (332),International Journal of Ophthalmology (268),Investigative Ophthalmology & Visual Science (206),Chinese Medical Journal (109),and Graefe′s Archive for Clinical and Experimental Ophthalmology (104).The 3498 papers were cited 12 030 times,3.44 times per paper.The rate of non-cited articles for 5-year,3-year and 2-year periods were 12.55％,24.21％ and 38.43％ respectively.[Conclusion]s Chinese ophthalmological papers indexed in SCI database have gradually increased.Chinese ophthalmological papers mainly originate in the affiliated hospital of universities and colleges.There are four ophthalmologic professional periodicals included in the top five in the quantity of articles.

BACKGROUND: Fluorine used for light-cured fluorine-containing resin can reduce and prevent dental caries, as well as play a long-term effect against tooth decay. However, there are rare reports on the composite preparation and performance.OBJECTIVE: To study the preparation and performance of the light-cured fluorine-containing resin. METHODS: Triethylamine as a catalyst, bisphenol A, bisphenol S, glycidyl methacrylate, trifluoroacetic anhydride and inorganic fillers (modified silicon dioxide, hydroxyapatite or titanium dioxide at mass fraction of 5％, 10％, 15％, 20％)were mixed to prepare the light-cured fluorine-containing resin. Then, the tensile strength, bending modulus,polymerization conversion and water of the composites were tested, and the morphology of the resin was observed under transmission electron microscope.RESULTS AND CONCLUSION: At the same mass fraction, the tensile strength was highest in the titanium dioxide group, higher in the hydroxyapatite group, and lowest in the silicon dioxide group (P < 0.05). At the same mass fraction, there was no difference in the bending modulus between the titanium dioxide group and the hydroxyapatite group (P > 0.05), while the bending modulus in the silica group was significantly higher than that in the other two groups (P < 0.05).At the same mass fraction, the polymerization conversion of the composite resin was higher in the titanium dioxide group than the hydroxyapatite and silicon dioxide groups (P < 0.05), but there was no difference between the latter two groups (P > 0.05). With the increasing of mass fraction, the water absorption of the composite resin kept an increasing trend.Under the transmission electron microscope, the fracture surface of the silicon dioxide group was relatively flat, and the resin body exhibited good biocompatibility with the filler; in the hydroxyapatite group, the fracture surface was rough with obvious ups and downs, and the biocompatibility between the resin body and the filler was relatively poor; in the titanium dioxide group, the fracture surface was layered and the filler settled in the resin body, and moreover, titanium dioxide particles were deposited on the bottom of the resin, resulting in larger voids and filler particles as well as poor biocompatibility. To conclude, the light-cured fluorine-containing resin has good mechanical properties, curable properties and absorption rate.

Objective: To observe effect of combination of TCM-WM with high colonic lavement for delaying renal failure. Methods: 98 cases of renal failure at compensatory phase were randomly divided into a treatment group treated with high colonic lavement, twice each week. 2 hours each time, and a control group treated with oral administration of coated aldehyde oxystarch,10g each time, thrice each day, 3 months constituting one course. Results: After lavenment. symptoms were improved, deceaseing velosity of the clearance rate of endogenous creatinine in blood and urine slowed lowered, renal survival rate of kidney increased, and the interval of dialasis and other replacement therapy obviously postponed in the treatment group as compared with that before treatment and the control group. Conclusion: The high colonic lavement has obvious therapeutiv effect in delaying renal failure velosity with a smaller stimulation to the stomach and smal intestine. It is an effective way for conservation treatment of renal failure.

The penal stipulation to the subject range about crime of illegal medical practice is too narrow,and there is also a great deal of contradictory regulation between Criminal Law and Practicing Physicians Law so it can not achieve the legislation goal.It is essential to revise the 1st section of "Criminal law "336th in order to expand the subject range and standardize the medical service market of our country.

Though affected by the COVID-19 epidemic in 2020, the Chinese Journal ofNeurology successfully overcame the difficulties and successfully completed the annual editing and publishing work. In 2020, editorial board meetings were held monthly to decide whether or not to publish a manuscript, 12 theme issues were published, nine guidelines and consensuses by the Chinese Society of Neurology were published, 10 continuing medical education articles by famous experts were published, and several COVID-19 related articles were quickly published. In 2021, efforts will be made to make the journal to a higher level.

Objective To find earliest or the best time for children with neonatal dacryocystitis acceptable treatment of lacrimal to shorten the course and improve treatment Methods Different time points after birth accepted probing treatment efficacy in children with neonatal dacryocystitis were retrospectively analyzed. Results Probing technique was effective for newborn infant with dacryocystitis. Symptoms recovered in 47 eyes,and 26 eyes were significantly improved with only a simple washing,there are 33 eyes need to wash and rinse probe or the expansion of the sclera again,and it was more common in the disease course of 4 ～6 months. Once probing technique treatment in the group( within 3 days) were effective in 23/34(67. 7% ) ,more than it in the group(more than 4 days) with effect of 24/72(33. 3%), One probing technique treatment in the group(within 10 days) were effect of 12/53(22.6%). Conclusion Press and simple washing techniques ineffective in children with neonatal dacryocystitis, was depended on operator proficiency, and time of lacrimal passage sounding could really advance the treatment to patients within 10 days after birth.