Objective To investigate the clinical features, diagnosis, treatment and prognosis of polymyositis patients with cardiac involvement.Methods Clinical data of 41 polymyositis patients with cardiac involvement were analyzed retrospectively.Results In our group, the percentage of polymyositis with cardiac involvement was 38.3%, and 25 (60.1%) out of the 41 patients were asymptomatic. Their average age was older than the cases without cardiac involvement ( P

Objective:To explore the importance and the breakthrough points of pharmaceutical care for patients with renal disease,especially using drugs with narrow therapeutic window and notable individual difference.Methods:Digoxin concentration and international normalized ratio (INR) were detected by clinical pharmacists,and then individualized pharmaceutical care was given to the patient according to the monitoring results.Results:Physician increased the monitoring frequency and adjusted the drug usage according to the patient's renal function.The patient's condition was improved and understood the necessity of related index monitoring.Conclusion:Clinical pharmacists can assist physicians in optimizing the treatment,and ensure safe,reasonable and effective medication by providing pharmaceutical care in various aspects.

Objective To compare the efficacy and safety of caffeine combined with humidified high-flow nasal cannula(HHHFNC) and nasal continuous positive airway pressure(nCPAP) on the treatment of apnea in very low birth weight (VLBW) preterm infants.Methods Totally 80 VLBW preterm infants with neonatal apnea,who were enrolled in the NICU of Hebei Province Children Hospital from September 2013 to March 2014,were randomly assigned to either HHHFNC group(39 cases) or nCPAP group(41 cases) according to respiratory support mode by random number table method,both groups were given caffeine.The incidence of severe apnea,incidence of reintubation,oxygen exposure time,duration of non-invasive ventilation time,feeding conditions and incidence of adverse events were compared.Results There were no significant differences in male/female ratio,gestational age,age at randomization and birth weight between the two groups(P ＞0.05).There were no significant differences in the incidence of severe apnea[15.4％ (6/39) vs 12.2 ％ (5/41)],incidence of reintubation [17.9 ％ (7/39) vs 19.5 ％ (8/41)],oxygen exposure time [(183.1 ± 31.2) h vs (175.9 ± 32.1) h],duration of non-invasive ventilation time [(163.3 ± 25.1) h v s (153.0 ± 26.2) h] between the two groups (P ＞ 0.05).The occurrence of abdominal distention [7.7 ％ (3/39) vs 24.4％ (10/41)],nasal trauma[2.6％ (1/39) vs 19.5 ％ (8/41)],head shaping [0.0％ (0/39)vs 29.3％ (12/41)] during treatment were lower in HHHFNC group than those of nCPAP group (P ＜ 0.05).Age began feeding was earlier in HHHFNC group than nCPAP group [(67.5 ± 19.1) h vs (96.3 ± 18.7) h,P ＜ 0.05],and day to full oral feeding was reduced in HHHFNC group than nCPAP group [(346.8±28.6) h vs (371.0 ±29.4),P ＜0.05].Conclusion HHHFNC combined with caffeine is effective on the treatment of apnea in VLBW preterm infants,and easier to make newborn tolerated.HHHFNC is an effective non-invasive respiratory support mode with few side effects.

[Objective] To learn the bibliometric characteristics of Chinese ophthalmological papers indexed in SCI database from 2007 to 2011.[Methods] All the ophthalmological papers published in the source journals indexed in the SCI database from 2007 to 2011 were retrieved.The papers of first authors were manually selected for bibliometric analysis.[Results] The ophthalmological papers published by Chinese scholars as the first author were 478,482,698,791,and 1049 from 2007 to 2011 (total 3498).The five institutions that published papers in the most were Sun Yat-sen University,Capital University of Medical Sciences,Fudan University,Hong Kong Chinese University and Shanghai Jiaotong University.The papers were distributed in 625 journals.The top five journals the papers were published in were Molecular Vision (332),International Journal of Ophthalmology (268),Investigative Ophthalmology & Visual Science (206),Chinese Medical Journal (109),and Graefe′s Archive for Clinical and Experimental Ophthalmology (104).The 3498 papers were cited 12 030 times,3.44 times per paper.The rate of non-cited articles for 5-year,3-year and 2-year periods were 12.55％,24.21％ and 38.43％ respectively.[Conclusion]s Chinese ophthalmological papers indexed in SCI database have gradually increased.Chinese ophthalmological papers mainly originate in the affiliated hospital of universities and colleges.There are four ophthalmologic professional periodicals included in the top five in the quantity of articles.

Synergistic Innovation is the developing trend and requirements of the times and society.Southern Medical University practiced joint mode among colleges and universities for excellent medical talent cultivation.Based on preponderant discipline and taking mechanism innovation as the key points,Southern Medical University actively explored the diversification mode of synergistic innovation.

[Objective] To discuss the therapeutic effect of different methods in the treatment of intertrochanteric femur fracture. [Methods]Totally 118 middle aged or old patients with intertrochanteric femur fracture were fixed with dynamic hip screw (DHS), Gamma nail or PFNA.[Results]Totally 112 cases were followed up, and the average time was 16 months, in those 45 patients were fixed with DHS: 29 were excellent, 11 cases were good, and 5 were poor, and the excellent to good rate was 88.9%; 36 patients were treated with Gamma nail, and the excellent, good, poor results were 28, 2, 1, respectively, and the excellent to good rate was 96.8%; 36 patients were fixed with PFNA, and the excellent, good, poor results were 29, 6, 1, respectively. The differences were significant (P=0.02, analyzed by Logistic regression with SPSS software). The excellent and good superiority of Gamma nail and PFNA were 5.1552 and 2.3726 times compared to DHS, and there was significant differences between the groups.[Conclusion]Surgical treatment of intertrochanteric femur fracture can improve the functional recovery and reduce the complication incidence, and PFNA fixing method can shorten the operative time, reduce the bleeding and the therapeutic effect is reliable, and suitable for old patients combined with osteoporosis.

Ethmoid Bone ; injuries ; Facial Bones ; injuries ; Humans ; Nasal Bone ; injuries ; Orbital Fractures ; surgery ; Osteogenesis, Distraction ; Skull Fractures ; surgery

Objective To observe the effect of Donglian capsule on nonenzymadc protein glycation.Methods An animal model of DM was established by injecting a little dosage of STZ in high fat-fed rats.When the models were established successfully,corresponding medicines were supplied for 12 weeks and then the blood glucose,glycosylation serum protein(GSP)and aldose reductase(AR)in rats semm were measured.Results Comparing with the model group,the levels of blood glucose,GSP and AR in Metformin Hydrochloride tablets group and Chinese medicine group were decreased markedly (P＜0.05).Conclusion Donglian capsule Can restrain nonenzymatic protein glycation and so thus prevent and treat DM.

Calcium/calmodulin-dependent protein kinaseⅡ (CaMKⅡ) has multiple functions, which made it play a central role in cardiovascular disease. Especially it activates numerous downstream targets in various signaling pathways that promotes vascular disease, heart failure, myocardial hypertrophy and arrhythmias. CaMKⅡcan impact calcium balance and increase calcium leak in myocardial cell via phosphorylating L type calcium channel, Ryanodine receptor (RyR 2) and phos?pholamban (PLN), and regulate ATP sensitive potassium current (IKATP) and late sodium current by affecting sodium channels and potassium channels. In addition, It can directly regulate transcription via activating the silk crack the original activated protein kinases (MAPKs) and acetylation enzyme (HDAC). These mechanisms have important roles in myocardial hypertro?phy, heart failure and arrhythmia. So we focus to demonstrating the structure and action mechanism of CaMKⅡto improve a new therapy of cardiovascular disease.

RNAi is an efficient antiviral system, and viral gene-specific siRNAs are very promising antiviral inhibitors. However, many viruses have evolved highly sophisticated mechanisms that interfere with both siRNA- and miRNA-guided silencing pathways. Deeper understanding the strategies exploited by viruses provides the basis for the development of effective RNAi-based therapies that prevent viral evading. Therefore, the latest progress on the strategies exploited by viruses for evading the RNAi is reviewed.