1.Tazarotene-Induced Gene 3 May Affect Inflammatory Angiogenesis in Psoriasis by Downregulating Placental Growth Factor Expression.
Su Young JEON ; Seung Min HA ; Dong Yeob KO ; Bon Seok KU ; Chae Young LEE ; Ki Hoon SONG ; Ki Ho KIM
Annals of Dermatology 2014;26(4):517-520
No abstract available.
Psoriasis*
2.Modified Ingram Therapy for Psoriasis.
Jai Il YOUN ; You Chan KIM ; Kyu Han KIM ; Ai Young LEE ; Yoo Shin LEE
Korean Journal of Dermatology 1988;26(1):63-67
No abstract available.
Psoriasis*
3.Two Cases of Interdigital Psoriasis Successfully Treated with Pimecrolimus Cream 1%.
Hei Sung KIM ; Hyun Jeong PARK ; Jun Young LEE ; Baik Kee CHO
Annals of Dermatology 2005;17(2):65-70
No abstract available.
Psoriasis*
4.Linear Psoriasis along Blaschko's Lines.
Annals of Dermatology 2017;29(1):106-107
No abstract available.
Psoriasis*
5.Linear Psoriasis along Blaschko's Lines.
Annals of Dermatology 2017;29(1):106-107
No abstract available.
Psoriasis*
6.A Case of Verrucous Psoriasis.
Young Jin KIM ; Hye Young LEE ; Ji Yeoun LEE ; Mi Kyeong KIM ; Tae Young YOON
Korean Journal of Dermatology 2012;50(5):487-488
No abstract available.
Psoriasis
7.Evaluation of the Potential Association between NOS Gene Polymorphisms (iNOS G-954C and eNOS G894T) and Psoriasis.
Xi DUAN ; Yan CHENG ; Linbo GAO ; Lijuan LI ; Tao WANG ; Min ZHANG
Annals of Dermatology 2016;28(1):110-112
No abstract available.
Psoriasis*
8.Clinical profile, morbidity and outcome of adult patients with psoriasis at a district hospital in Northern Malaysia
Chai Har Loo ; Yong Chieh Chan ; Kai Quan Lee ; Tharmalingam Palanivelu
The Medical Journal of Malaysia 2015;70(3):177-181
SUMMARY
Introduction: Psoriasis is a common, chronic, relapsing,
immune-mediated inflammatory disease. Our objective is to
review the clinical profile, co-morbidities, and outcome of
patients with psoriasis.
Methods: This is a cross-sectional study of outpatient
psoriasis patients attending the dermatology clinic, Hospital
Sultan Abdul Halim (HSAH) between January 2012 and June
2014. Data collection was based on Malaysian Psoriasis
Registry.
Results: Among 296 patients with psoriasis, Malays were the
most common 175 (59.1%), followed by Indians 82 (27.7%),
Chinese 37 (12.5%) and others 2 (0.6%). Male to female ratio
was 1.2:1. More than half (54.7%) of the patients had early
onset disease (age 40 or less). Only 26 patients (8.8%) have
positive family history. The most common clinical
presentation was chronic plaque psoriasis (89.9%), followed
by erythrodermic psoriasis (4.7%), guttate psoriasis (3.0%)
and pustular psoriasis (1.7%). Twenty eight percent had nail
involvement while arthropathy was seen only in 14.7%.
Common triggers were sunlight (46.0%), stress (31.1%),
trauma (5.4%), food (4.0%), pregnancy (4.0%), and upper
respiratory tract infections (2.7%). Co-morbidities observed
include ischaemic heart disease (7.1%), hypertension
(26.7%), dyslipidemia (17.6%), and diabetes mellitus (22.0%).
All patients were on topical medications. About 6.8% of the
patients were treated with phototherapy. One third of
patients (35.5%) were given systemic therapy. Out of these,
84 patients (80.0%) were on methotrexate while only 16
(15.2%) on acitretin. None was on cyclosporine or biologic.
In term of disease severity, 41.7% of patients had BSA >10%
and 31.4% patients had DLQI > 10.
Conclusion: Our patients show a similar clinical profile and
outcome as our Malaysian psoriasis population. However
they tend to have a more severe disease. There is a need for
a more effective targeted therapy for a better outcome.
Psoriasis
9.Causes of mortality in patients with psoriasis in Malaysia –Evidence from the Malaysian Psoriasis Registry
Zhenli Kwan ; Chin Aun Yeoh ; Azura Mohd Affandi ; Fatimah Afifah Alias ; Muneer Hamid ; Nurakmal Baharum ; Adrian Sze Wai Yong ; Roshidah Baba
The Medical Journal of Malaysia 2015;70(5):273-277
Background: Patients with severe psoriasis, namely those
requiring phototherapy or systemic treatment, have an
increased risk of death. The aim of this study was to
determine the prevalence, aetiology and risk factors for
mortality among adult patients aged 18 years and above with
psoriasis in Malaysia.
Methods: This was a retrospective study involving adult
patients notified by dermatologists to the Malaysian
Psoriasis Registry between July 2007 and December 2013.
Data were cross-checked against the National Death
Registry. Patients certified dead were identified and the
cause of death was analysed. Multivariate analysis using
multiple logistic regression were conducted on potential
factors associated with higher risk of mortality.
Results: A total of 419 deaths were identified among the
9775 patients notified. There were four significant risk
factors for higher mortality: age>40 years (age 41-60 years
old, Odds Ratio (OR) 2.70, 95%CI 1.75, 4.18; age>60 years
OR 7.46, 95%CI 4.62, 12.02), male gender (OR 1.72, 95%CI
1.33,2.22), severe psoriasis with body surface area (BSA)
>10% (OR 1.52, 95%CI 1.19, 1.96) and presence of at least
one cardiovascular co-morbidity (OR 1.67, 95% CI 1.30,
2.14). Among the 301 patients with verifiable causes of
death, the leading causes were infection (33.9%),
cardiovascular disease (33.6%) and malignancy (15.9%).
Conclusion: Infection was the leading cause of death among
psoriasis patients in Malaysia. Although cardiovascular
diseases are well-known to cause significant morbidity and
mortality among psoriasis patients, the role of infections
and malignancy should not be overlooked.
Psoriasis
10.Clinico-epidemiological profile, including body mass index of Malaysian children with psoriasis
Siew Eng Choon ; Chin Fang Ngim ; Premaa Supramaniam ; Kwee Eng Tey ; Nalini Nanu Madhavan
The Medical Journal of Malaysia 2016;71(4):171-176
background: Limited information exists regarding paediatric
psoriasis and its association with body mass index (bMI) in
Asia.
Objectives: to determine the clinico-epidemiological profile
and to compare the bMI of children with and without
psoriasis.
Methods: A case-control study of 92 children with psoriasis
versus 59 with atopic eczema and 56 with non-inflammatory
skin conditions.
results: Psoriasis was more common in Malay and Indian
children when compared to Chinese with odds ratios (Or) of
4.30 (95% CI, 1.85-9.99) and 3.00 (95% CI, 1.02-8.81)
respectively. Prevalence of psoriasis was similar between
Malay and Indian children (Or 1.43, 95% CI, 0.63-3.25).
Male:female ratio was 1:1.09. the mean onset age of
psoriasis was 7.9 years. Median onset age was earlier in
males (6.5 years versus 9.0 years in females, p=0.05).
Plaque psoriasis was the most common phenotype (89.1%)
and 94.5% had scalp lesions. Arthritis was seen in 4.3%.
Odds of excess adiposity, defined as bMI ≥85th percentile,
was higher in children with psoriasis versus noninflammatory
controls (Or 2.35, 95% CI 0.99-5.56, p= 0.052).
No increased risk of adiposity was noted between children
with psoriasis and eczema (Or 1.14, 95% CI 0.5-2.62,
p=0.753). More children with psoriasis (17.4%) and eczema
(20.3%) were underweight (bMI <5th percentile) compared to
non-inflammatory controls (10.7%).
Conclusion: Malays and Indians are three to four times more
likely than Chinese to have psoriasis in multi-ethnic
Malaysia. Plaque psoriasis is the most common phenotype.
Odds of excess adiposity is about two times higher in
children with psoriasis compared to non-inflammatory
controls although this observation just missed conventional
statistical significance.
Psoriasis