[Objective]To study the risk factors of neurosurgical postoperative intracranial infection.[Methods]Analyse 30 cases of intracranial infection after the neurosurgery operation from 2003 to 2008 in our department.[Results]The intracranial infections after craniocerebral operation is related to the operation duration,cerebrospinal fluid leakage,external ventricular drainage,laying the drainage-tube,open craniocerebral injury.[Conclusion]To shorten the operation time as long as possible,tighten dural closure to prevent leakage of cerebrospinal fluid,with strict control of the indwelling time, reduce the number of drainage-tube and shorten indwelling time after neurosurgery operation as possible as we can,can reduce the possibility of intracranial infection after neurosurgery operation.