1.Rare variations in the Origin, Branching Pattern and Course of the Celiac Trunk: Report of Two Cases
Lokadolalu Chandracharya Prasanna ; Rohini Alva ; Guruprasad Kaltur Sneha ; Kumar M R Bhat
Malaysian Journal of Medical Sciences 2016;23(1):77-81
Multiple anomalies in the celiac arterial system presents as rare vascular malformations, depicting deviations of the normal vascular developmental pattern. We found a common left gastro-phrenic trunk and a hepato-spleno-mesenteric trunk arising separately from the abdominal aorta in one cadaver. We also found a common hepatic artery and a gastro-splenic trunk arising individually from the abdominal aorta in another cadaver. Even though many variations in the celiac trunk have been described earlier, the complex variations described here are not mentioned and classified by earlier literature. Knowledge of such variations has signifi cance in the surgical and invasive arterial radiological procedures in the upper abdomen.
Celiac Artery
2.Novel Piperine compound AB05 (N-5-(3,4-dimethoxyphenyl) -2E,4E pentadienylpiperidine) inhibits H1N1 influenza virus propagation in vitro
Mohammed, A. ; Velu, A.B. ; Al-Hakami, A.M. ; Meenakshisundaram, B. ; Esther, P. ; Abdelwahid, S.A. ; Irfan, A. ; Prasanna, R. ; Anantharam, D. ; Harish, C.C.
Tropical Biomedicine 2020;37(No.4):1062-1073
Pandemic H1N1 influenza virus respiratory illness has become an inevitable global
health concern. With antigenic drift, it becomes necessary to have drugs over tailor-made
HIN1 vaccine every year. In the current study, we screened many Piperine derivative in
which, N-5-(3,4-dimethoxyphenyl)-2E,4E-pentadienylpiperidine (AB05) and was further studied
for anti-H1N1influenza virus activity and compared with other stains in-vitro on MDCK cell
line. Initial cytotoxic doses of AB05 for the MDCK cell line were > 25µM. The results showed
a dose-dependent reduction of the viral plaque’s in the adsorption assay with EC50 of 0.33 µM.
The mechanism of AB05 was by inhibition of matured viral release as evaluated by the time
of virus addition with incubation of 6-10 hours. With the promising H1N1 virucidal activity of
AB05, we included various strains of human influenza virus to screen AB05 inhibition of
Neuraminidase (NA). The result showed 70% NA inhibition in WSN (H1N1), 90% in H3N2 &
Influenza B and 49% in Tamiflu resistant H1N1). Further our In silco docking studies
substantiated experimental results by showing the difference in binding and cooperation
between H1N1 and N3N2. Together these observations illustrate that Piperine derivative
AB05 is a promising lead molecule which needs further evaluation in animal models.