Losing an eye can be a fatal experience for a patient. The deformed appearance of the face resulting after an oncosurgery may results in psychological trauma as well as social embarrassment for the patient. It is a challenge to manage the defect on the face with surgery. Maxillofacial Prosthodontist can fabricate and rehabilitate defects with orbital and periorbital prosthesis. The defect can be restored with custom made orbital prosthesis consisting of orbital globe made up of heat cured acrylic resin and periorbital prosthesis made up of silicon elastomeric material, which can give real life like appearance and also improves the quality of life of the patient. The patient can feel more comfortable and accepted in the social circle. A multidisciplinary approach and team management are essential in providing more accurate and effective rehabilitation of such defects. This case report presents the fabrication of a custom made orbital and periorbital prosthesis for a patient.