Store operated calcium channels (SOCCs) are referred to as plasma membrane calcium channels that are opened in response to a depletion of intracellular calcium stores. SOCCs are broadly distributed in excitable and non excitable cells, and may play important roles in conducting intracellular calcium signals, modulations of cell functions and gene expression. Although the current understanding of SOCCs related mechanism is still limited, the physiological significance of SOCCs and their possible links to certain diseases have been suggested. Future study of highly selective SOCCs modulating agents may promote not only related research, but also the development of novel therapeutic drugs.