Beta-fluoroethylacetate has been extensively used as the rodenticide in Korea. In some patients with acute poisoning, beta-fluoroethylacetate caused cerebellar dysfunction as a single and persistent neurologic sequela after a period of an acute neurological disorder which is characterized by mental deterioration, seizures, and respiratory failure. But there has been no report of pathological findings to explain neurological deficit. We tried to verify the histologic changes of the central nervous systems in beta-fluoroethylacetate poisoned rats. Silver staining(Gallyas) was used to evaluate the histology. In acute intoxication experiment with LD50(7mg/Kg), beta-fluoroethylacetate elicited acute onset of consciousness deterioration, generalized tonic-clonic seizures and large amplitude tremulous activity involving whole body with full recovery after 24 hours. There was no discernible pathologic change in CNS in acutely poisoned rats. However, when poisoned with sublethal dose(5mg/Kg) daily for five days, a moderate degree of nerve cell degeneration was found selectively in dentate nucleus, Purkinie cell layer, vestibulo-cochlear nucleus and striatum. This change was not seen in hippocampus, cerebral cortex or cerebellar cortex. These findings were well correlated with the previous reports of selective pathology in human 5-FU intoxication cases. Our preliminary results suggest that beta-fluoroethylacetate, a kind of cellular metabolism inhibitor may induce selective neuropathology mainly involving cerebellar output pathway in rats.
Humans ; Rats ; Animals ; Poisons

Calibration ; Humans ; Poisons ; urine

There was no acute toxic on rabbit's bodies after ingested activated charcoal suspension (1g/kg and 1,2g/kg body weight). Circulating blood cells and the function of kidney and liver were not changed after 7 days ingested activated charcoals
Animal Experimentation ; Poisoning ; Poisons

From 1997 to 2000, 22 children aged 5-15 (11 boys, 11 girls) were admitted in emergency department of Pediatric Institute due to intoxincation of Moc dieu. Only 9/17 (52.9%) of subjects described exactly the toxic plant. The most significant clinical signs are vomit and fatigue (100%), jaundice (100%). Hemorrhage of various degree around the orbit (17/17) and the sclera, 15/17 cases of edema and aliogourine. This is a life threatening intoxication in mild and mode rate cases, the prognos is of treatment at the institute is good, only 1 death
Child ; Poisoning ; Poisons

By synthesizing and analysing poisoning analyses from 1996 to 2000 at Hai Phong Viet Tiep Hospital found an increasing incidence of insecticide and raticide poisons. Incidence of insecticide and raticide was 21.18% in 1996, in which raticide rate was 5.08%, raticide rate was 20.11% in 2000, there were a noticeable rate of raticide poisons without knowing the origin of the raticide in chinese (called chinese raticide). The poisoning analyses played a considerable role in giving first aid for poisons in general and for insecticide and raticide poisons in particilar
Insecticides ; Poisons ; Epidemiology

Naturenz, a mixture of plant oxydase, protease, natural anti-oxydants, aminoacids and vitamins has been used for treating dioxin exposed patients. This preparation can improve the patients status. An icrease of SH-group, of total hem content and of anilin hydroxylase acitivty in blood, a decreasing of urine urobilinogen was notified on patients after administration
Dioxins ; Chemistry ; Poisons

The exact of Zingiber officinale Rosc (ZO) and ZO-Typhonium divaricatum Decne (TD) complex were used to evaluate its antiemetic effect and acute toxicity on young dogs and mice. The results showed that the extract of ZO in dose of 0.1 g/kg body weigh, ZO 0.1 g and TD 0.12 g complex/kg body weigh per oral route have antiemetic effect in comparison with control one. Both of raw and pure TD extracts have equal effect. ZO and TD have a quite low acute toxicity
Animal Experimentation ; Poisons ; Pharmaceutical Preparations

Herbicides ; poisoning ; Humans ; Occupational Exposure ; Poisons

OBJECTIVES: To retrospectively analyze homicide cases of death after injection and provide reference for forensic identification. METHODS: Six homicide cases of death after injection which were investigated by the Criminal Investigation Team of Shanghai Public Security Bureau were collected and analyzed, including case situation, scene investigation, autopsy and other materials. RESULTS: The 6 cases were premeditated crimes, 5 cases took place in private spaces, and 5 cases involved the victims approached by suspects' decoy. There were no obvious abnormalities at the scene of the 6 cases. In 6 cases, the victim's body surface injury was mild or no, lividity color was abnormal, and the needlestick injury showed different manifestations from conventional medical measures. CONCLUSIONS Death after injection is a highly concealed crime and easy to be ignored. For the suspected injection injury found in autopsy, it is necessary to carefully examine, identify and analyze, be alert to the situation of injecting poison (drug) and do a good job in evidence fixation and material extraction.
Autopsy ; China/epidemiology* ; Homicide ; Poisons ; Retrospective Studies

Purpose: There has been no nationwide surveillance survey of poisoning cases in Korea. This study examined the clinical characteristics of poisoning admissions in order to obtain preliminary data for future planning. Methods: This study retrospectively reviewed the data on poisoning admissions of 150 hospitals based on the hospital discharge injury surveillance data of Center for Disease Control and Prevention in Korea from January to December in 2004. The demographic data, poisons used, causes of poisoning, reasons for attempted suicide and mortality rate was investigated according to the age group. The factors associated with mortality were also evaluated. Results: A total 836 patients admitted for poisoning were analyzed. Their mean age was 46.5+/-19.5 years (male 415, female 421). The most frequent age group was the 4th and 5th decades. The most common poisons involved were pesticides (45%) and medications (23%). The majority (64%) involved intentional poisoning except for those in the 1st decade. The most common reason for the attempted suicide was family problems. However, individual disease was the most common reason in those over 60 years. The overall mortality rate was 8.7% (73/836). Pesticides and being elderly (over 65 years old) were strongly correlated with fatality. Conclusion: The incidence of intentional poisoning increases from the 2nd decade making it a preventable injury. "Overall, the incidence of intentional poisoning increases from the 2nd decade". Therefore, there is a need to frame a prevention policy corresponding to each factor related to fatality, such as an elderly population and pesticides.
Aged ; Centers for Disease Control and Prevention (U.S.) ; Female ; Humans ; Incidence ; Korea ; Pesticides ; Poisons ; Retrospective Studies ; Suicide, Attempted