The use of the term "placebo" was discussed for very long ago, "placebo" had been used in therapy in associating with jugglery, religion, leading to the art of treating disease. Most physicians recognize the efficacy of placebo and magicians have got success. Placebo has latin origine as "placere" and in singular of future tense it means "I shall make a pleasure".
Placebos ; therapy ;

This study evaluates the effect of a commercial brand of chicken essence (BEC) on the various parameters related to stress and cognition of human volunteers. BEC is produced by a hot-water extraction process from chicken meat under high pressure conditions. It contains concentrated amounts of proteins, amino acids and peptides such as carnosine compared to homemade traditional chicken soup. Due to the unique extraction process, it has been postulated that readily absorbed amino acids and bioactive peptides are present in BEC. In this study, we evaluated the effect of BEC in comparison with a placebo on a group of distressed medical students. Students were randomly divided into two groups and given either BEC or a placebo drink daily for two weeks. Before and after the two weeks, the students were given a series of tests to assess their level of cognitive functioning and perceived stress level while being monitored for EEG recording. The combination of these tests, namely Digit span, Arithmetic and Letter-number sequencing, generally assessed the student’s attention and working memory. The working memory performance of students who ingested essence of chicken was found to be significantly better than those who consumed placebo when data comparing baseline and after two weeks consumption were compared. This study seems to suggest that essence of chicken has positive effects on the subjects’ cognitive functions.
Chickens ; seconds ; week ; cognitive ability ; Placebos

The acute effect of a single−dose of caffeine on the P300 event−related brain potential (ERP) was assessed in a study using a repeatedly presented auditory oddball button−press task. A dose (5mg/kg body−weight) of either caffeine or placebo lactose, dissolved in a cup of decaffeinated coffee, was administered double−blindly to coffee drinkers who had abstained from coffee for 24hrs, with the presentation order of the sessions counterbalanced and separated by 2−4 weeks. The caffeine−treatment condition demonstrated a smaller P300 amplitude and a shorter latency overall than the placebo treatment condition. The mean P300 amplitude value difference (caffeine minus placebo) increased with the successive trial blocks. Caffeine ingestion appears to yield a lower resource−consumption and a net increase in allocating attention resources for task performance across repeated measurements.
Caffeine ; Acute ; Caffeine Measurement ; Placebos ; Measured

Attitude to Health ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Placebos

BACKGROUND: Palmar hyperhidrosis is a common disorder of excessive sweating. A number of studies have demonstrated the effectiveness of iontophoresis in the treatment of palmar hyperhidrosis. However, controlled clinical studies on iontophoresis for palmar hyperhidrosis have been limited. OBJECTIVE: To determine the efficacy and safety of iontophoresis in the treatment of palmar hyperhidrosis with a randomized, sham-controlled, single-blind, and parallel-designed study. METHODS: Twenty nine patients with significant palmar hyperhidrosis were enrolled in this study. They received active iontophoresis treatment (group A) or sham treatment (group B). Iontophoresis was performed 20 minutes each time, five times per week, for 2 weeks. Its efficacy was assessed with starch-iodine test, mean sweat secretion rate, and hyperhidrosis disease severity scale. RESULTS: Twenty-seven of the 29 patients completed the 2-week treatment. After completion of 10 times of treatment, results of the starch-iodine test showed clinical improvement in 92.9% of patients in group A and 38.5% of patients in group B (p=0.001). The mean sweat secretion rate was reduced by 91.8% of patients in group A and by 39.1% of patients in group B (p<0.001). Improvement in quality of life was reported by 78.6% of patients in group A and by 30.8% of patients in group B (p=0.028). In group A, one case of localized adverse event was noted, although no adverse event was encountered in group B. CONCLUSION: Tap water iontophoresis could be used as an effective and safe treatment modality for palmar hyperhidrosis.
Humans ; Hyperhidrosis* ; Iontophoresis* ; Placebos ; Quality of Life ; Sweat ; Sweating ; Water*

We conducted a meta-analysis to investigate the efficacy of ginseng supplements on fatigue reduction and physical performance enhancement as reported by randomized controlled trials (RCTs). RCTs that investigated the efficacy of ginseng supplements on fatigue reduction and physical performance enhancement compared with placebos were included. The main outcome measures were fatigue reduction and physical performance enhancement. Out of 155 articles meeting initial criteria, 12 RCTs involving 630 participants (311 participants in the intervention group and 319 participants in the placebo group) were included in the final analysis. In the fixed-effect meta-analysis of four RCTs, there was a statistically significant efficacy of ginseng supplements on fatigue reduction (standardized mean difference, SMD = 0.34; 95% confidence interval [CI] = 0.16 to 0.52). However, ginseng supplements were not associated with physical performance enhancement in the fixed-effect meta-analysis of eight RCTs (SMD = −0.01; 95% CI = −0.29 to 0.27). We found that there was insufficient clinical evidence to support the use of ginseng supplements on reducing fatigue and enhancing physical performance because only few RCTs with a small sample size have been published so far. Further lager RCTs are required to confirm the efficacy of ginseng supplements on fatigue reduction.
Fatigue* ; Outcome Assessment (Health Care) ; Panax* ; Placebos ; Sample Size

While continuing its journey to the West, traditional Chinese medicine (TCM) encounters various barriers. The ten most challenging issues in TCM clinical research are: (1) the justification of the specificity of acupuncture points; (2) the evidence of the effectiveness of manual needle manipulation; (3) the role of placebo in TCM practice; (4) the advantage of TCM pattern differentiation in clinical management; (5) quality control of Chinese herbs and optional formulation for current practice; (6) the classification of herbal medicine based on safety and toxicity; (7) the efficacy of herbal medicine for specific diseases or symptoms proven by randomized double blinded controlled clinical trial; (8) interactions between Western drugs and herbal medicine; (9) the application of Western medical diagnosis, pathology, imaging data, and test results in TCM pattern differentiation; (10) the best clinical set-up and model for TCM practice in modern society. There is no doubt that the understanding and resolving of these issues will significantly accelarate the acceptance of TCM by the scientific community and the Western society.
Acupuncture Points ; Biomedical Research ; Drugs, Chinese Herbal ; Medicine, Chinese Traditional ; Placebos ; Randomized Controlled Trials as Topic

Depressive Disorder, Major ; drug therapy ; psychology ; Humans ; Placebos ; therapeutic use ; Prescriptions ; Treatment Outcome

OBJECTIVETo assess the long-term (up to 6 months) safety profile of a 3-month regimen of NeuroAiD for acute ischemic stroke.

METHODSA total of 190 patients with acute ischemic stroke were identified for eligibility in a randomized, double-blind, placebo-controlled clinical trial, of which 150 patients allocated to either receiving NeuroAiD (80 cases) or placebo (70 cases) were analyzed after dropouts due to absence of baseline data, early death, or noncompliance. Both groups received treatment for three months and followed up for another three months after the completion of the treatment. Occurrence of clinical adverse events and laboratory parameters were assessed at 1 month, 3 months (while under treatment) and 6 months (3 months after the completion of treatment). Statistical comparisons between groups were performed using chi-square test or t-test whenever appropriate.

RESULTSThe two groups had comparable baseline characteristics. Mild nausea was more commonly reported in patients taking NeuroAid compared with placebo (P=0.01), of which 9 out of 10 were observed only during the first month of treatment. However, none of the adverse events reported were considered severe or required discontinuation of the study drug. There was no significant change observed in mean arterial blood pressure, haemoglobin, renal and liver laboratory parameters during treatment with NeuroAid and up to 3 months after completion of a 3-month regimen.

CONCLUSIONNeuroAiD is safe and does not affect hematologic, hepatic, and renal functions during and long after completion of treatment.

Aged ; Brain Ischemia ; therapy ; Double-Blind Method ; Female ; Humans ; Male ; Patient Compliance ; Placebos ; Stroke ; therapy

INTRODUCTIONThe management of psychogenic movement disorders is fraught with difficulties. Empathy and a non-judgmental manner are essential in dealing with patients, and a neurobiological explanation of the symptoms may help to foster trust, acceptance, understanding and recovery.

CLINICAL PICTUREWe report a 17-year-old Chinese girl with psychogenic blepharospasm. Her parents refused psychotherapy and pharmacotherapy.

TREATMENT AND OUTCOMEPlacebo therapy (with parental consent) was prescribed with favourable results.

CONCLUSIONWe examine the ethical considerations for and against placebo therapy, and explore the role of placebo therapy in the management of psychogenic movement disorders.

Adolescent ; Blepharospasm ; psychology ; therapy ; Female ; Fraud ; Humans ; Placebo Effect ; Placebos ; therapeutic use