1.The relationship between serum CXC chemokine ligand-10 level and Graves' disease
Fengling MENG ; Yingying ZHAO ; Pinli LIU ; Hong ZHOU ; Yonggui DENG ; Mian WANG ; Lihui ZHANG ; Shengou SU
Chinese Journal of Endocrinology and Metabolism 2012;28(3):217-219
The serum level of CXCL10 was determined in both patients with Graves' disease (GD) and normal control subjects.Serum CXCL10 levels in untreated and relapsed GD groups were higher compared with the remission group and control group( P<0.01 ).A significant difference was observed between the former two GD groups (P<0.01 ),but no difference was found between latter two groups( P>0.05 ).Serum CXCL10 levels were positively correlated with FT3 and FT4,and negatively correlated with TSH by multiple linear regression analysis( P<0.01 ).
2. Comparison of age-based clinical and abnormal immune parameters in patients with Henoch-Schönlein purpura
Na ZHANG ; Peijing GUO ; Pinli LIU ; Hongrong YANG ; Jing XIAO ; Xinpeng LI ; Jinbo HUANG ; Yizhou ZHENG
Chinese Journal of Hematology 2017;38(1):60-64
Objective:
To explore age-based clinical and immune parameters in Henoch-Schönlein purpura (HSP) to determine clinically useful markers reflecting disease characteristic.
Methods:
A cohort of 502 patients with HSP were enrolled into this retrospective study to evaluate their clinical and immune data.
Results:
Majority HSP cases occurred at age ≤14 years and showed significant immune imbalances of ESR, CD3+ cells, CD4+ cells, CD3-CD16+CD56+ cells, CD4+/CD8+ cells, IgG, IgA, IgM, IgE, complements C3/C4 and ASO in the acute phase. Compared to patients aged >14 years, symptoms of joint were more frequent at disease onset in patients aged ≤14 years (20.8%