Objective: To study the stability of four kinds of cardiovascular ready-prepared Chinese medicine (Injections of Ciwujia, Shenmai, Dengzhanhuasu and Gegensu) in Betahistine Hydrochlorizel Sodium Chloride Injection. Methods: Four kinds of drugs were added into Betahistine Hydrochloride Sodium Chloride, respectively, and mixed, then observed for 6 hours at 23?C. Results: The appearance, pH value and concentration of four drugs above mentioned were stable in Betahistine Hydrochloride sodium chloride sodium chloride at room temperature (23?C) and in 6 hours. Conclusion: Injections of Ciwujia, Shenmai, Dengzhaihuasu and Gegensu are stable in Betahistine Hydrochlonile Sodium Chloride.

This paper aims to conduct a literature meta-analysis of the results of existing empirical researches about the relationship between fiscal decentralization and supply of public health service in China.It was found that the different empirical results of the impact of China''s fiscal decentralization on the supply of public health services are subject to different research characteristics.The actual results of the impact, especially the significant effect, are influenced by the characteristics of the starting year, the year of termination, and the number of models, whether the model contains population density, transfer payments, degree of openness, and whether the independent variables include the fiscal expenditure decentralization.Through the funnel plot asymmetry test, it was found that there was publication bias in the sample literature.

Objective To investigate clinical application of critical value of platelet count and its threshold adjustment . Methods Theincidence rate and regularities of distribution of critical value of platelet count were retrospectively analyzed in pa‐tients ,whose platelet count was ≤50 × 109/L from Jan .2012 to Dec .2013 .And the suitable critical values of platelet count for dif‐ferent clinic units were set through clinical coordination .Results The platelet count were detected in 193 776 samples ,and detection results of 1 602 samples reached the critical value of platelet count (detection rate was 0 .83% ) .The critical value of platelet for he‐matology unit was adjusted to ≤10 × 109/L ,for surgical unit was adjusted to ≤50 × 109/L ,and for other units the critical value was still ≤20 × 109/L .Meanwhile ,cases were regarded as reaching the critical value when detection results of platelet count were differ by 50% in short time .Conclusion The adjustment of critical value of platelet count for different units could improve efficiency of clinic and laboratory ,and enhance safety of patients .

The ultrastructures of synapses in the head of caudate nuclei of rats were studied by means of electron microscopic technique. The experimental group of rats, in which the pain threshold was elevated after electro-acupuncture, showed no change of the number of the granular vesicles, but a significant decrease of the number of clear synaptic vesicles (without dense core) in the presynaptic boutons. This might be correlated to release of acetylcholine in the synapse.

Many malignant tumors, most commonly small cell lung cancer, merge with syndrome of inappropriate secretion of antidi-uretic hormone (SIADH). SIADH is caused by the neuroendocrine function of tumor cells or is a side effect of chemotherapeutics. As a chemotherapeutic side effect, SIADH presents as hyponatremia. Therapy for SIADH includes both treatment for primary diseases and hyponatremia. Given that SIADH-induced hyponatremia aggravates the prognosis and shortens the survival time of patients with malig-nant tumors, SIADH is an independent risk factor for prognosis. Therefore, the early diagnosis, monitoring, and treatment of SIADH will improve the prognosis of patients with malignant tumors.

Adenosine is an important signaling molecule of the central nervous system (CNS). Adenosine typically released in the phosphorylated form(ATP), together with neurotransmitter, both of which are encapsulated in the synaptic vesicles. Once released into the synaptic space, adenosine molecules will bind to their three categories of receptors, namely A1 receptor (A1R), A2 receptor (A2R), A3 receptor (A3R), and therefore start G protein mediated signaling pathways, resulting in various and extensive biological effects. It has been discovered in recent years that adenosine has a certain level of anti-depression effect, although its mechanisms are yet to be elucidated. This review summarized the researches focusing on anti-depression roles of both adenosine and its receptors.

Objective:To study the effect of overdose fluoride on Smad3 expression during development course of Wistar rat's incisor,and then to explore pathogenesis of dental fluorosis.Methods:20 Wistar rats(10 male rats and 10 female rats)were randomly divided into two groups.Experiment group was feed with water contained 0.1 g/L fluorin and normal group with distilled water was served as control.After 8 weeks all rats were sacrificed.Immunohistochemistry was used to observe the effect of overdose fluorin on Smad3 expression in rat's ameloblast and odontoblast.Results:The immunohistochemistry results demonstrated that in experiment group,Smad3 expression in rat's ameloblast and odontoblast was lower than those in control group,and statistic analysis showed there were significant differences between the two groups(P

Objective To evaluate the efficacy and safety of the combination of Weimaining capsule and XELOX regimen (oxaliplatin plus capecitabine) in the treatment of advanced gastric cancer patients.Methods A total of 62 patients with advanced gastric cancer who fulfilled all predetermined criteria were randomly divided into observation group and control group.The 31 patients in observation group received a combination of Weimaining capsule and XELOX regimen,the 31 patients in control group received only XELOX regimen at the same dose intensity.Each patient received at least two cycles (1 cycle =21 days) of treatment,the efficacy was assessed after two cycles.Results The median time-to-progression (TTP) of observation and control groups were 5.5 and 4.8 months,respectively.The difference had no statistical significance (P =0.238).The disease control rates (DCR) of observation group was significantly improved compared with control group [67.7 ％ (21/31) vs 41.9 ％ (13/21),P ＜ 0.05],the difference was statistically significant,while the objective response rate (ORR) of the 2 groups had no statistical difference [(32.3 ％ (10/31) vs 25.8 ％ (8/31),P ＞ 0.05].In drug safety aspects,there was no Ⅴ grade adverse reactions (deaths caused by drug) among all the patients.Rates of grades Ⅱ-Ⅳ neutrocytopenia and nausea,vomiting in observation group were obviously lower than control group [16.13 ％ (5/31) vs 38.71％ (12/31),P ＜ 0.05;12.90 ％ (4/31) vs 35.48 ％ (11/31),P ＜ 0.05],other adverse reactions between the 2 groups had no statistical difference.Conclusions A combination of Weimaining capsule and XELOX regimen in the treatment of advanced gastric cancer patients can improve DCR significantly and reduce part of adverse reaction induced by chemotherapy with satisfactory safety.This method is worthy of application widely.

Objective To investigate the effects of NO synthesis inhibition on pain threshold and binding capacity of NMDA receptor of hippocampus in rats. Methods Sixty-six SD rats of both sexes weighing (210 ? 20)g were randomly divided into 11 groups of six. Group I was used for determination of baseline values of pain threshold and binding capacity of NMDA receptor. In the five L-NAME groups (group Ⅱ-Ⅵ) 1% L-NAME in normal saline 50mg?kg-1 was given intraperitoneally (IP) . In the acute experiment pain threshold was determined 15 min (group Ⅱ ) and 30 min (group Ⅲ) after L-NAME IP injection. In the chronic experiment L-NAME 50mg?kg-1 was given IP twice a day for 1 day (group Ⅳ), 4 d (group Ⅴ) and 7 d (group Ⅵ) and pain threshold was measured 12h after last L-NAME administration. Group Ⅶ-Ⅺ served as control groups in which normal saline was given IP instead of L-NAME. Pain threshold was measured by response latencies following CO2 laser stimulation which was delivered to the medial surface of the ear. After determination of pain threshold the animals were decapitated and hippocampus was removed. The binding capacity of NMDA receptor with [3H] MK-801 was determined. Bmax and KD were determined by Scatchard analysis. Results There was no significant difference in pain threshold and binding capacity of NMDA receptor between group Ⅱ ,Ⅲ (acute experiment) and their control groups ( Ⅻ,Ⅷ). In chronic experiment pain threshold significantly increased after 1 and 4 d of L-NAME administration (group Ⅳ and Ⅴ) but return to the baseline value on the 7th day. NMDA receptor binding capacity increased in all three groups of chronic experiment. Bmax was significantly higher than the baseline value on the 4th and 7th day (group Ⅴ and Ⅵ). KD was significantly higher than the baseline value on the 4th day (group Ⅴ) but returned to the baseline on the 7th day (group Ⅵ) . Conclusions In chronic experiment NO synthesis inhibition can increase pain threshold to laser thermal nociceptive stimulation and induce changes in the affinity and density of NMDA receptor.

Objective To study the cognitive tendencies in recognizing negative emotional faces.Methods The experiment used the traditional flanker paradigm for reference.Forty-eight university students (19 males,29 females) finished the flanker tasks deigned by E-Prime, and their accuracy rate and reaction time were recorded in the study.Results ANOVA revealed that,in all cases,the accuracy rate of anger was significant higher than fear and sadness (96.60% ,94.50% ,94.40% ) (P＜0.05).And when the flanking stimuli were fear faces or there were no flanking stimuli, the reaction time of anger was much shorter than fear and sadness ( respectively,fear(801.27 ± 140.99) ms,anger(723.94 ± 151.37 ) ms, sadness(812.21 ± 148.85 ) ms; fear(788.17 ±148.81 ) ms, anger ( 694.28 ± 111.99 ) ms, sadness (763.57 ± 133.91 ) ms, P ＜ 0.05 ).When the flanking stimuli were anger or sadness faces, the reaction time of anger was significant shorter than fear( respectively, fear( 824.09 ± 164.42) ms, anger (721.48 ± 124.06 ) ms, sadness ( 760.50 ± 131.12 ) ms; fear ( 798.95 ± 146.40) ms, anger (702.55 ± 136.07 ) ms, sadness (750.48 ± 133.86) ms, P ＜ 0.05).Conclusion There are no flanker effects in recognizing different negative emotional faces, but there are anger superiority effects of face recognition and cognitive tendencies, which is helpful for clinical diagnosis and treatment of some diseases associated with emotional disorders.