1.Clinical significance of serum procaleitonin and C -reactive protein testing for pneumonia
Chinese Journal of Primary Medicine and Pharmacy 2015;(12):1866-1868,1869
Objective To investigate serum procalcitonin(PCT)and C-reactive protein(CRP)and clinical significance of changes in children with pneumonia.Methods 123 cases of childhood pneumonia included 48 cases of bacterial infection,mycoplasma infection in 36 cases,39 cases with viral infections,40 cases of physical healthy children were selected as the control group.They were measured in serum PCT and CRP content of the correlation between test results and analysis of clinical final diagnosis.Results The level of PCT in Bacterial pneumonia group, Mycoplasma pneumonia group and viral pneumonia group were (5.80 ±1.92)μg/L,(0.45 ±0.15 )μg/L and (0.32 ±0.17)μg/L,respectively,significantly higher than control group(0.19 ±0.10)μg/L(t =5.37,3.41,1.23, all P <0.05);the level of CRP in Bacterial pneumonia group,mycoplasma pneumonia group and viral pneumonia group were(45.34 ±13.35 )mg/L,(28.63 ±11.37)mg/L and (8.19 ±2.07)mg/L,respectively,significantly higher than control group(3.85 ±1.31)mg/L(t =5.37,3.41,1.23,all P <0.05);serum PCT sensitivity to detect pneumonia children,specificity and the positive predictive were 93.56%,82.35% and 69.25%,respectively,higher than serum CRP diagnosis of pneumonia sensitivity,specificity and positive predictive(χ2 =4.41,5.83 and 7.62, respectively,all P <0.05).Conclusion Serum PCT and CRP measurement can be used as an auxiliary to identify indicators of childhood pneumonia,the diagnosis of pneumonia in children has important clinical significance.
2.Progress of research on relationship between gene p16 and lung cancer
Journal of International Oncology 2010;37(11):852-855
p16 tumor suppressor gene plays an important role in early diagnosis for lung cancer. The occurrence of lung cancer is closed associated with p16 gene aberrant methylation in promotor, seconed exon homozygous deletion, gene point mutation , lose of protein and mRNA expression. Also p16 is related to gene therapy and drug target therapy. This review will summarize the relationship between p16 and lung cancer.
3.A method of assessing the thickness of myocardial basement membranes
Chinese Pharmacological Bulletin 2003;0(10):-
Aim To observe the thickness changes of cardiomyocyte and microvascular basement membranes(BM)and the expression of collagen Ⅳ in Gk rats of different months and STZ-induced diabetic rats,and to explore the method that operated easily and could assess the thickness of myocardial BM.Methods GK rats of the fourth,fifth,sixth,seventh months,Streptozotocin induced diabetes rats of fifth months and normal Wister rats were respectively divided into different groups with ev eight rats in each group.The myocardial section was stained by methenamine silver and immunohistochemistry was performed for collagen Ⅳ.Left ventricular endocardium was selected as measuring view.Through computer image analysis,the ratio of BM positive staining density(BMPSD)and positive staining density of collagen Ⅳ(CPSD)were calculated separately in all myocardium.Take the ratio to assess the thickness of myocardial BM and the expression of collagen Ⅳ.Results The glycemia,BMPSD and CPSD of the two diabetes rats were higher than those of the normal rats,having highly remarkable difference(P0.05).Conclusion By methenamine silver staining for myocardial section,calculating BMPSD through computer image analysis,can be an index to assess the thickness of myocardial BM.
4.Intra-artery infusion chemotherapy plus radiation therapy for the treatment of invasive bladder cancer
China Oncology 2001;0(05):-
Purpose:To evaluate the effects of intra-arterial infusion plus radiation therapy as a treatment for invasive bladder cancer. Methods:24 cases of invasive bladder cancer were treated from 1995 to 2003. All were treated with intra-arterial infusion chemotherapy plus radiation therapy. Results:CR+PR was 91.6%(22?24). In the 22 cases with indications for total cystectomy, the normal bladder function was preserved. The quality of life and the survival period improved. Conclusions:Intra-arterial infusion chemotherapy plus radiation therapy is an effective method for invasive bladder cancer, especially for the patients who can not tolerate burden or do not accept cystectomy.[
5.Enforcement of Programmed Management in the Introduction of New Drugs
China Pharmacy 2005;0(22):-
OBJECTIVE:To set up and improve the procedures and methods for the introduction of new drugs into hospital.METHODS:A supervising system on the introduction of new drugs was established and a programmed management on the introduction of new drugs was put into practice.RESULTS & CONCLUSIONS:A series of measures such as establishing expert database for the evaluation of the introduction of new drugs,assuming supervision throughout the course carried out by discipline inspection committee,increasing clinical pharmacy evaluation and monitoring after the introduction of new drug,etc.have achieved good outcome in the management on the introduction of new drugs,which help promote hospital's fair,transparent and scientific introduction of new drugs.
6.Management of Application of Perioperative Prophylactic Antimicrobial in Orthopedic Patients
China Pharmacy 2005;0(18):-
OBJECTIVE: To discuss the feasibility of application of perioperative prophylactic antibiotics in orthopedic patients. METHODS:Intervention, feasible regulations and rational medication scheme were formulated and present medical records were monitored and related information was feedback timely. Utilization of perioperative prophylactic antimicrobial was compared between before and after intervention. RESULTS: In the intervention group, hospitalization days, medical costs, cost and proportions of antibiotics were reduced; medication time and selection of antibiotics for all kinds of incision were standardized and the mean duration was shortened. The proportion of antibiotics used at 0.5～2 hours before operation was increased. The first and second generation cephalosporin was applied more and more. Combination of medication was decreased and rational use of antibiotics was significantly improved. CONCLUSION:Management of drug use is helpful to standardize the application of perioperative prophylactic antibiotics and improve clinical rational use of antibiotics.
7.Investigation of nurses′learning motivation and learning satisfaction with continued education and the influencing factors
Modern Clinical Nursing 2015;(4):4-8
Objective To investigate nurses′ learning motivation and learning satisfaction with continued education and analyze its influencing factors. Method One hundred and seventy-nine nurses were enrolled in the survey and the general information questionnaire, education participation scale and continuing education learning satisfaction scale were used in the investigation. Results The average score by nursing education participation scale was (3.26 ± 0.59), and that of continuing education learning satisfaction scale was (2.74 ± 0.48). There were statistically significant differences in age, length of employment, professional title, marital status, employment mode between the scores by the two scales (P < 0.01). Conclusions Nurses′ learning motivation and learning satisfaction with continuing education are in the medium level. Pertinent guidance such as bringing continuing education in depth and width is suggested to improve satisfaction and motivations of nurses.
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