Diagnosis, Differential ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Hepatitis B ; complications ; Humans ; Liver Cirrhosis ; drug therapy ; etiology ; Medicine, Chinese Traditional ; Phytotherapy

Animals ; Diagnosis, Differential ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Evidence-Based Medicine ; Hepatitis B, Chronic ; drug therapy ; Humans ; Liver Cirrhosis ; drug therapy ; Medicine, Chinese Traditional ; Phytotherapy

Humans ; Liver Cirrhosis ; physiopathology ; therapy

Animals ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Liver Cirrhosis ; therapy ; Phytotherapy

The authenticity and accuracy of data in clinical trials is extremely important. Any inauthentic data may affect the result of a clinical trial, and cause great loss. In our opinion, inauthentic data includes not only man-made spurious data, but also inaccurate data objectively formed. In this article, the features of inauthentic data are described, how to distinguish inauthentic data is discussed, and the causes of this kind of data are analyzed and concluded, which include: subjective intervention on the result of clinical trials, differentiation of the GCP knowledge level between different investigators, misunderstanding of the protocol, et al. And finally we propose that scientific training to investigators and other involved personnel and quality control during the course of data collection should be strengthened to prevent the occur of inauthentic data in clinical trials.
Clinical Trials as Topic ; standards ; Data Collection ; standards ; Drug Evaluation ; Drug Industry ; Humans ; Quality Control

Fibrosis ; Humans ; Integrative Medicine ; Liver Cirrhosis ; diagnosis

Humans ; Liver Cirrhosis

The state of automobile exhaust pollution in the Kunming area was investigated. 113 traffic police and 105 official police were examined. The incidence of symptoms and diseases of the respiratory system and low pulmonary function was higher in the exposed group than in the control group. This shows that automobile exhaust has some effects on the health of people of special occupation.

OBJECTIVE:To establish a RP-HPLC method for the determination of Peoniflorin in Tiaojingquban tablets. METHODS:The chromatographic separation was performed on VP-ODS column (150mm?4.6mm, 5?m). The mobile phase consisted of methanol-water (25∶75) at a flow rate of 1.0mL?min-1.AUV-detector at 230nm was used. RESULTS:The linear range of Peoniflorin was 24.8～198.4?g?mL-1(r=0.999 9).The mean recovery was 99.36% with RSD being 0.86% (n=6).CONCLUSION:The method is simple, rapid, sensitive and reproducible, and it can be used for the quality control of Tiaojingquban tablets.

This issue of Journal of Clinical Hepatology focuses on integrated traditional Chinese and Western medicine and has invited the experts who are engaged in the diagnosis and treatment of hepatobiliary & pancreatic diseases using integrated traditional Chinese and Western medicine.With reference to their clinical practice of diagnosis and treatment and related studies,the special topics introduce how to give full play to the advantages of both traditional Chinese and Western medicine to improve patients'benefits and related developmental issues and show the perspectives of the development of integrated traditional Chinese and Western medicine.