Breast Neoplasms ; pathology ; Female ; Humans ; Middle Aged ; Neoplasm Metastasis ; Neoplasms ; pathology ; Nose Neoplasms ; secondary ; Skin Neoplasms ; secondary

How to acquire new tumor antigens is a hotspot in cancer research currently.According to the nature of antigen epitope binding its ligand,we can identify and get unknown antigen epitope even its amino acid sequence through some analytical techniques and experiments,from T lymphocytes and monoclonal antibody levels.So the molecular mechanisms of tumor immunity will be more distinct.

Objective To explore the clinical value of combined detection of antiperinuclear fac-tor (APF) ,anti-RA keratin antibody (AKA) and anticyclic citrullinated peptide antibody (anti-CCP) in diagnosis and differential diagnosis of rheumatoid arthritis (RA). Methods Totally 119 RA pa-tients,101 non-RA rheumatisants and 39 healthy controls were enrolled in the study. Enzyme linked immunosorbent assay (ELISA) was applied to quantitately detecting anti-CCP antibody; immunofluo-rescence method was applied to quantitately determining AKA and APF. Then the quadruple tabular form was used to calculate the sensitivity and specificity. Results In RA group,the sensitivity of APF, AKA and anti-CCP antibody was 48.8% ,32.3% and 83.5% respectively; the specificity was 92. 2%, 93. 1% and 94.1 % respectively. Conclusion Three autoantibodies,including APF,AKA and anti-CCP antibody have high specificity in early diagnosis of RA. Combined detection of the three antibodies con-tributes to diagnosis and differential diagnosis of rheumatoid arthritis (RA).

Objective To explore whether health examination save medical insurance fund or not. Methods To observe the sparing medical cost which 371 health examination people avoid repeated checking and shorten the length of stay during hospitalization from March 2006 to March 2007. To observe the effect of sparing medical cost because of regular health examination, early discovery diseases, pretreatment promptly and avoidance transforming to advanced diseases. Results Because of avoiding repeated checking and shortening the length of stay,everybody save the medical cost about 570 yuan,371 people can save about 21 ten thousands yuan. To statistics the average hospital cost of different courses of eight common diseases and malignant tumors from January to November at 2007, we discovered that the medical cost is large distinction between the earlier period and advanced stage of disease. For example: the medical cost of one stage of hypertension is 6608 yuan ,the two stage is 8838 yuan ,the three stage is 13 869 yuan, and the stage of hypertensive heart disease is 13 033 yuan. Parts of health examination crowd who stay at my hospital from 1996 were visited for five years ,we conformed many chronic diseases by prompt intervention can relieve and even reverse, avoiding the transformation to incurable disease which will consume a large number of strength and money. Conclusion Health examination resource is a medical treatment resource which isn't restricted by social security fund, the utilization can not only save medical cost but also discover and treat diseases earlier, thus we can save the strength and money before the advanced diseases.

BACKGROUND: The discrepancies of the ideal self and the actual self (called as type A in this article), the objective self and the actual self(called as type B), the looking glass-self and the actual self(called as type C) are important study subjects and closely related to health psychology.OBJECTIVE: To probe into relationships between the discrepancies of type A, B, C self-concepts and mental health about Chinese college students, and try to provide scientific basis for mental health education of college students.DESIGN: Sampling investigation and cross-sectional study design based on the college student SETTING: Department of Psychology of Capital Normal University. PARTICIPANTS: From January to March 2002, in Beijing, we randomly chose 337 undergraduates who were of grade 2-3 from 9 classes in China University of Political Science and Law University(97 students), Universityof Petroleum, Beijing(85 students), China Public Security University(103students) and Capital Normal University(52 students). In Shanghai, Shanghai University(150 students from 7 classes in grade 2): In Changchun, Northeast Normal University(120 students from 4 classes in grade 1 -2).The total of participants were 607, but 51 participants were excluded for all kinds of reasons, at last, 556 valid participants took part in this study.METHODS: The self-concept-scale questionnaires was used for this study,including four subscales of the ideal self, the actual self, the object self and the looking-glass-self which were used to measure Chinese undergraduates'self-concept-discrepancies of A, B and C types; symptom checklist-90 scale (called SCL-90) was used to measure undergraduates' mental health. MAIN OUTCOME MEASURES: The self-concept-discrepancies of three types(A, B, C), mental health and their relationships of Chinese college students. RESULTS: ① The descriptive statistics about the discrepancies of self-concepts of three types(A, B, C) of college students: type A (65.0±39.2)discrepancy was bigger than type B(-30.1± 28.2); type B was bigger than type C (-0.11± 24.7); ② Compared to the adult normal of symptom checklist-90(SCL-90), the college students responded to SCL-90 was normai, showing majority of college students were mental healthy; ③ Type A and B discrepancies of college students significantly correlated with 10 factors of SCL-90(P＜0.01), whereas the correlation between type C discrepancy and 10 factors of SCL-90 was not significant; ④ Regression analyses predicting SCL-90 showed that A type(β=0.32) discrepancy contributing to SCL-90 was more bigger than type B (β= 0.24), type B was more bigger than type C (β= -0.14).CONCLUSION: The correlation of the discrepancies of the ideal self and the actual self, the discrepancies of the objective self and the actual self withmental health were statistically significant; but the correlationof the discrepancy of the looking-glass-self and the actual self with mental health was not statistically significant.

After the specific tools and process to mine and collect subject hotspot information from papers pub-lished in English journals,Chinese journals and patents were summarized in order to standardize,schematize,simplify and clarify information collection, mange information service and insure subject hotspot information quality, the push methods and contents of subject hotspot information were described with measures proposed for the solution of problems in subject hotspot information service.

Health management is developing very fast as a new subject.The ethical problem in which there is rare in reports.Discussion about the ethical problems appears in health management and health examination,such as privacy protection,sex morality,excess service,healthy morality,humanities concern,cooperation between each section and so on,has a important actual significance.

Objective To evaluate the effects of preoperative sleep disturbance on the consumption of propofol during the period of general anesthesia and postoperative sleep quality.Methods Sixty-five patients scheduled for elective thyroidectomy surgery under general anesthesia were enrolled in the study.According to the preoperative Pittsburgh Sleep Quality Index (PSQI) score,the patients were divided into sleep normal group (n =33) and sleep disorder group (n =32).Anesthesia was induced and maintained with propofol given by closed-loop target-controlled infusion (CLTCI).The consumption of propofol during the period of general anesthesia,postoperative sleep quality in the evening of surgery and at 24 h after operation,and the painful levels of the patients at 1 d and 2 d after operation were compared between two groups.Results The totalconsumption of propofol in sleep disorder group [(1 024.33 ±213.02)mg] was more than that in sleep normal group [(892.25 ± 242.30) mg] (P ＜ 0.05),and the dosage of unit surface area per minute of propofol in sleep disorder group [(4.94 ± 0.80) mg/(min · m2)] was also more than that in sleep normal group [(4.45 ± 0.96) mg/(min · m2)] (P ＜ 0.05).Each group suffered from bad sleep quality in the evening of operation,and got improvement one day later (P ＜ 0.05).The sleep quality in sleep disorder group was improved after general anesthesia (P ＜ 0.05).Conclusions Preoperative sleep disturbance increased the consumption of propofol in the general anesthesia.General anesthesia can improve the sleep quality of the patients who suffered from sleep disorder.

Effective management for hypertension in renal diseases should be carried out according to the principles of 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension.The important role of kidney in the classification of hypertension,the corresponding therapy,the set of the target blood pressure,the choice of antihypertensive agents and combination therapy should be focused.Comprehensive approaches should be used for the treatment of hypertension in renal diseases to protect the target organs(including the kidney).Appropriate prevention and management strategies for hypertension in renal diseases should be disseminated and optimized.

Objective To compare the rDNA-ITS differentiation and its regulation between Morinda (officinalis) and its counterfeit species, and provide DNA molecular markers for the fingerprint identification of them. Methods The rDNA-ITS regions of M. officinalis and its counterfeit species were amplified and sequenced, then analyzed by means of CLUSTRAL X and MEGA softwares. Results The internal transcribed spacers (ITS) including ITS1, 5.8S, ITS2, and partial 18S and 26S were determined. In DNA DIST analysis, the range of diversity among M. officinalis and M. shughuaeusis, M. umbellata was (2.9%-)5.8% and 2.9%-4.2% based on ITS1 and ITS2; the range of diversity between M. officinalis and Damnacanthus indicus was 21.2% and 18.9% based on ITS1 and ITS2. Phylogenetic tree based on ITS and 5.8S sequence data indicated the M. umbellata and M. shuanghuaensis were closely related then with M. officinalis, while D. indicus was monophyletic group. Conclusion The rDNA-ITS sequence is a better molecular marker for idertification of M. officinalis and its counterfeit species.