A study the quantitative measurement of DNA content in 3 normal lacrimal glands, 18 pleo-morphie adcnomas and 21 lacrimal gland carcinomas was carried out by flow eytometry. The results showed that pleomorphie adenomas still had the characteristics of DNA content of the normal diploid lacrimal gland cells. The significant increase of DNA index (DI) in pleomorphie adenomas might mean malignant transformation. DNA content of malignant tumor increased evidently and its aneuploid ratio was higher than in pleomorphic adenomas (76.2% VS 16.8%) (P

Adult ; Female ; Fluorides ; adverse effects ; Fluorine ; urine ; Humans ; Hydroxyproline ; urine ; Male ; Middle Aged ; Occupational Exposure ; adverse effects ; Young Adult

Coronary Disease ; etiology ; Humans ; Hypertriglyceridemia

Coronary Disease ; prevention & control ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; therapeutic use ; Primary Prevention ; methods

Thrombospondin-1 expresses in a variety of tumors and induces endothelial cell apoptosis,thus inhibits tumor angiogenesis and prevents tumor growth.It function domain ( Type I sequence):3TSR,retaines the function of inhibit angiogenesis,has the certain practical significance in clinical cancer treatment.

Nrf2/Keap1/ARE is an important signaling pathway in maintaining the balance between peroxide and antioxidants. Once oxidative stress happened, Nrf2/Keap1/ARE would be ac-tivated to regulate the expression of downstream antioxidant pro-teins that could reduce the injury from oxidative stress and the level of oxidative stress. Recent researches show that Nrf2/Keap1/ARE signaling pathway is closely related to refractory re-spiratory diseases such as pulmonary fibrosis (PF), lung canc-er, chronic obstructive pulmonary disease (COPD), suggesting that Nrf2/Keap1/ARE signaling pathway may be a potential ther-apeutic target. This review focuses on the role of Nrf2/Keap1/ARE signaling pathway in refractory respiratory diseases in order to further understand the related mechanism and provide evidence for the diagnosis and treatment of refractory respiratory diseases.

Objective To investigate the analgesic efficacy of ultrasound guided transversus abdominis plane block and to compare the efficacy of posterior approach and medial approach of ultrasound guided transversus abdominis plane block (TAPB) in providing postoperative analgesia after children laparoscopic groin surgery.Methods Eligible children 2 ～ 4 years old (n =60),American society of anesthesiologists (ASA) I,undergoing elective laparoscopic unilateral groin surgery were randomly assigned into posterior approach group (Group P),medial approach group (Group M) and control group (Group C).Many parameters were measured and recorded during the study,including funk sedation scores,intraoperative circulation monitoring at time points of T1 (before induction),T2 (skin incision) and T3 (skin closure),length of surgery,the time from post anesthesia care unit (PACU) arrival to the first obtainable pain score,length of PACU stay,modified-children's hospital of eastern ontario pain scale(m-CHEOPS),pediatric anesthesia emergence delirium (PAED) scores,number of children with sufentanil administered in PACU,number of people occurred nausea and vomiting,and satisfaction of parents.Results There were no statistically significant difference in general characteristics,basic emotion score,duration of surgery,the time from PACU arrival to first obtainable score,haemodynamic parameter at T1 and satisfaction of parents among groups P,M,and C.However,the m-CHEOPS scores at the time points of first obtainable,10 min,the number of children received sufentanil administration,PAED scores and haemodynamic parameter at T2 and T3 were significantly lower in groups P and M than in group C.There were no significant difference in parameters mentioned above between groups P and M.Conclusions Ultrasound guided transversus abdominis plane block could provide efficient and secure postoperative analgesia for children undergoing laparoscopic groin surgery.Both posterior approach and medial approach are ideal options.

Anticholesteremic Agents ; adverse effects ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; adverse effects

ObjectiveTo understand the effect of student standardized patient-case teaching in orthopedic surgery.Methods A total of 120 clinical medicine students were selected,and they were randomly assigned to be research group ( n=60 ) and control group ( n=60 ),as students standardized patient,10 clinical medicine students and postgraduate students of orthopedic surgery were selected,and standardized patient-case teaching was applied to the students in research group while traditional case teaching was applied to students in control group.After teaching,the teaching effect and survey the feedback information about teaching form students were evaluated.ResultsTotal mark of effect evaluation of 2 groups is 83.50 + 6.55 and 71.11 ± 6.57,and both operational score and knowledge study achievements of research group were better than control group (P＜0.01),over 80％ research group students effect evaluation being positive.ConclusionStudent standardized patient-case teaching is helpful to improving students' study in orthopedic surgery and the teaching effect is remarkable.