Objective To investigate the curative effect of telbivudine versus lamivudine in chronic hepatic B with a therapy of 48 weeks. Methods 94 patients who were diagnosed chronic hepatitis B were investigated. The therapeutic group and the control group (n = 47) were respectively assigned to receive 600mg of telbivudine and 100mg of lamivudine in 48 weeks. Copies of HBV-DNA、serum markers、alanine transarninase(ALT) level were tested before therapy and 4 weeks、12 weeks、24 weeks、48 weeks in the the course of treatment. The HBV-DNA conversion、HBeAg conversion and the normal rate of the ALT were compared. Results The copies of HBV-DNA decreased as the treatment progressing,especially at the 4 thweek. Conversion rate of the HBV-DNA of the telbivudine group was 72.3% ,which was higher than the lamivudine group 42.6%. There is a significant difference between two groups (x2 = 8.530,P ＜ 0.05). 95.7% of ALT in the telbivudine group revived to normal level versus 91.5% of the lamivudine group became normal. There is no significant difference between two groups (P ＞ 0.05). At the end of treatment,the rate of the HBeAg converting to negative in the telbivudine group is 38.3% versus the lamivudine group 31.9%, but there is no significant statistical difference between two groups(x2 = 0.420 ,P ＞ 0.05). The frequence of seroconversion of HBeAg in the telbivudine group is 23.4% versus the lamivudine group 17.0%, but no statisticall difference between two groups (x2 = 0. 594, P ＞ 0.05). Conclusion It was more effective to treat the HBeAg positive chronic hepatitis with telbivudine than lamivudine,and lower frequence of seroconversion of the HBV-DNA、HBeAg.

Service for childbirth is obviously special.Because every tache in childbirth can affect the health and life safe of babies and mothers.At present the humanistic service is still not popularized in maternity of hospitals.So it is possible to happen contradictions or bothers between doctors and patients.Therefore,thinking from ethics,we should adopt effective measures,develop the humanistic service and management,and satisfy the lying-in women completely,to establish harmonious relationships between doctors and pationts

Nosocomial infection had been the focus conc erned by society at home and abroad since the viral infection such as HIV、HBV and HCV which had seriously threaten the human health worldwide. We should strengthen t he blood products and syringe management and implement sterilization measure，wi th that safe blood starts with me. Because of that quite a few of new human viru ses continually emerged in recent years， control and prevention of nosoc omial viral infection was currently imperative, important and formidable project s and global thorny issue of public health in the 21st century too.

Recently,the interest in a new surgical procedure named natural orifice transluminal endoscopic surgery has blossomed worldwidely.During these several years,quite a number of natural orifice transluminal endoscopic surgery experiments have been carried out on porcine models and even on humans,including transvaginal cholecystectomies,transgastric appendectomies,transvaginal appendectomies,transvesical peritoneoscopies,etc.This review article aims to discuss the current research status and the challenges of orifice transluminal endoscopic surgery.

Objective:To explore the necessity of monitoring polysomnography (PSG ) in snoring children.Method:The PSG were monitored in 162 children with snoring or apnea.Acording to results of PSG,162 cases were separated into two groups:group obstructive sleep apnea hypopnea syndrome(OSAHS) and group primary snoring(PS),monitoring data including:apnea hypopnea index(AHI),snoring index(SI),lowest oxygen saturation(LSaO_2) and time of SaO_2<0.9,all data were undertaked statistical analysis. Result:In all 162 snoring cases,150 cases(92.6%) belong to group OSAHS,12 cases(7.4%) belong to group PS;Differences of data of age,sex and body mass index(BMI) are not significant but that of AHI,SI,LSaO_2 and time of SaO_2<0.9 are significant(P<0.05).Conclusion:It's necessary to monitor PSG in snoring children for early diagnosis and correct treatment to avoid disadvantage of OSAHS.

Objective: To analyze economic operation situation of public hospital of traditional Chinese medicine in Jiangsu. Methods: Through the investigation and analysis, to collect situation of hospital health resources, medical service, the resources utilization efficiency and balance. Based on the actual data on the present situation and the development of hospitals of traditional Chinese medicine, the systematic analysis of the income and expenditure was made. Results: The problems in the development of Chinese medicine hospitals and the countermeasures are found, references for the medical institution managers and the basis for policy makers are provided. Conclusion: Hospitals of traditional Chinese medicine need to continue deepening the reform, and actively developing the features of TCM advantages, finding their own positioning goals, trying to explore development service of traditional Chinese medicine and Chinese medicine products, so as to cultivate the self-core competitiveness.

After the specific tools and process to mine and collect subject hotspot information from papers pub-lished in English journals,Chinese journals and patents were summarized in order to standardize,schematize,simplify and clarify information collection, mange information service and insure subject hotspot information quality, the push methods and contents of subject hotspot information were described with measures proposed for the solution of problems in subject hotspot information service.

Objective To perform statistical analysis of low frequency electromagnetic comprehensive therapy apparatus for adverse events,and the characteristics of the adverse events,and investigate the risk factors,thus to provide effective information for the safe of the medical device.Methods Using database software from national MDR monitoring center,preliminary study on safety of low frequency electromagnetic comprehensive therapy apparatus was performed.Results The manifestations of adverse events was 50.0%,mainly included skin allergy and scald,burn, stabbing pain,25.0% included treatment without feeling,parts damaged,other manifestations accounted for 25.0%. Conclusion Monitoring should be strengthened in order to reduce or avoid the vaginal dilator adverse events.

To eliminate cancer hazards to human health,the development of the therapeutic cancer vaccine has been given more and more attention.By contrast of tradition therapy,cancer immunotherapy take the advantage of being able to achieve target therapy and take modest harm to organism.Here,we first idiscussed the mechanisms of cancer immune escape,and reviewed the design principles of therapeutic cancer vaccine,as well as the latest research progress of therapeutic cancer vaccine and its application.

Objective To discuss the application of image sensor in wireless endoscopic micro-electro-mechanical-system (MEMS). Methods Through the comparison of various types of image sensors, and in the consideration of the environment and requirement inside the body, CMOS image sensor which can output analog image signal with high density of integration, low power consumption, small profile was chosen as the sensor component of a wireless endoscope. The profile and power consumption of some specific models of this type of image sensor were compared and analyzed.Results The problems, such as ground connection, crystal configuration and the layout of circuit board, were reasonably solved during the design of image sensor's schematic circuit diagram. The image capture module based on OV7930 sensor was designed and manufactured. Images were successfully captured during the animal experiments.Conclusion The application and design of image sensor in a wireless endoscopic MEMS are feasible.