Introduction: Diarrhea is the most common disease of children particularly in those under 5 years old. In Lao PDR, diarrhea is responsible for 12% of all childhood deaths and the disease is increasing. Therefore, there is a need to study optimal disease management in Lao patients Methodology: A retrospective study was carried out by reviewing medical records of patients admitted at the Pediatric Infectious Ward, Mahosot Hospital, Vientiane Capital from 01/01/2017 to 31/06/2018. We included those diagnosed with acute diarrhea aged 15 years old or younger. Finding: Three hundred and seventy children with diarrhea were included in the analyses, with a higher proportion of males than females [230 (62.2%), 140 (37.6%)] with a ratio of 1.6:1. Mean (SD) age of the patients was 2.1±2.33 years old. The most common age group was those < 2 years old with 247 cases (66.8%), followed by the age group of 2-5 years old [92 cases (24.9%)], 5-10 years old [25 cases (6.8%)] and 10-15 years old [6 cases (1.6%)]. The management in patients without clinically-evident dehydration was ORS in 161 (98.7%), IV fluid in 115 (71.5%) and antibotics in 12 (7.4%). For patients with moderate dehydration, the management consisted of giving ORS in 370 (100%), IV fluid in 198 (96%) and antibotics in one (0.5%). One patient with severe dehydration was given ORS and IV fluid. Conclusion High proportion of diarrhea found in children under 5 years old. Management in patients without clinical dehydration were rehydration with ORS and IV fluid because patients refused to drink ORS.