No abstract available.
Pharmacokinetics*

No abstract available.
Nortriptyline* ; Pharmacokinetics*

The study was carried out on 30 healthy volunteers (16 males, 14 females), aged 21-40. Cyclosporine A (CsA), Neoral®, dosage of 2 mg/kg body weight (rounded nearest to 25 mg), was given at hours as 0 (starting time), 12, and 24. The blood samples were collected at hours 0, 2, 4, 6, 8, 12 (before the 2nd dose), 24 (before the 3rd dose) and 36. The CsA concentrations were measured with fluorescence polarization immunoassay (FPIA) with the TDx analyser, Abbott. Results: Pharmacokinetics of CsA, oral micro-emulsion, in Vietnamese volunteers have the characteristics: Cmax = 763 ± 241 ng/ml, Cmin = 358 ± 104 mg/ml/mg/kg, tmax = 2.3 ± 1.1 h, AUC 0-4 = 1756 ± 561 ng.h/ml, AUC0-4 /dose/kg = 827 ± 250 ng.h/ml/mg/kg, AUCinf = 3725 ± 983 ng.h/ml, AUCinf/dose/kg = 1756 ± 433 ng.h/ml/mg/kg, t1/2 = 4.1 ± 1.2, Cl/F = 30.5 ± 6.9 L/h. The inter-individual variation in pharmacokinetics is presented with the coefficient of variations (CVs) of Cmax, AUC 0-4, AUCinf as 31.6%, 31.9% and 26.4%, respectively. The concentration of C2 has an important linear relationship with AUC0-4 (r = 9.987, p <0.0005), inversely there is no linear relation between C12 (the trough C0: before 2nd dose of CsA) (r = -0.189, p= 0.32). Cmax/dose/kg, AUC0-4/dose/kg and AUCinf/dose/kg in female volunteers were lower than those in male volunteers (p<0.005)
Pharmacokinetics ; Cyclosporine

This study introduced Macrolid antibiotic class including effects, classification, pharmacokinetics, indication of treatment, and future prospects
Macrolides ; Pharmacokinetics

The aim of this research is to investigate the mechanism and kinetics of drug release from the core and coated pellets containing sodium diclofenac. Avicel was found to be a good excipient to prepare matrix-type pellets. The drug release could be sustained up to 12 hours. the rate of drug release was fit to Higuchi's model. The microphotograph revealed that the drug release was controlled by the diffusion from the isoluble matrix. The drug release was sustained up to 24 hours. The rate of drug release was fit to Higuchi's model, too. The mechanism of drug release was determined to be the diffusion from insoluble matrix and through the insoluble membrane.
Diclofenac ; Pharmacokinetics

No abstract available.
Humans* ; Pharmacokinetics*

OBJECTIVETo investigate the relationship of properties and drug release rate of hot melt pressure sensitive adhesive (HMPSA), and to provide a recommendation of preparing and selecting of HMPSA for transdermal use.

METHODHMPSA with different properties were prepared using styrene-isoprene-styrene triblock copolymer as main material, and the tacks, adhesions and cohesions were determined. Drug-in-adhesive type patches were prepared using alpha-asarone as model drug, and the drug release rates were investigated on single chamber diffusion cells using 60% ethanol solution as release media.

RESULTThe prepared HMPSAs had different tacks, adhesions and cohesions. The drug release rates of HMPSA patches were related to the cohesions. The release rate decreased when the cohesion increased.

CONCLUSIONThe HMPSA with appropriate cohesion should be selected when preparing patches to balance the drug release rate and patch property.

Ganoderic acid(GA) is one of main bioactive components produced by Ganoderma lucidum,which a traditional Chinese herbal medicine and a kind of tracyclic triterpene lanosterol derivatives with highly oxidized structure. It has a variety of important pharmacological activities,such as anticancer,immunoregulation,anti-oxidation,anti-diabetes and anti-HIV. At present,the studies of GA mainly focus on biosynthesis,fermentation control,isolation and purification,structure identification and pharmacological effects.However,there are a fewer pharmacokinetic studies of GA,although it is closely related to the clinical application. Recent studies have shown that GA can be absorbed rapidly by gastrointestinal tract and distributed in various tissues and organs after oral intake. GA is metabolized by liver at phase Ⅰ and phase Ⅱ,and then mainly excreted by bile. In this paper,the pharmacokinetic characteristics of GA and its absorption,distribution,metabolism and excretion(ADME) will be systematically summarized,in order to provide scientific basis for the application and development studies of Ganoderma triterpenoid drugs and their rational clinical use.
Humans ; Lanosterol ; pharmacokinetics ; Reishi ; chemistry ; Triterpenes ; pharmacokinetics

To effectively and safely treat diseases for the older, it needs to thorough understand the changes of pharmacokinetics such as absorption, distribution, metabolism, and excretion of drug; of pharmacodynamics and side-effects of drugs; of drug interactions, including interactions between drug and drug, or between drug and disease; to obey the principles of prescription for older by basic access, adjustment of dose... Incompliance of drug use is a big problem that often be forgotten in the treatment, and accounted for 50% of older patients. Impaired cognitive performance in older is one cause of incompliance
aged ; Therapeutics ; Pharmacokinetics

Background: Hemoglobin is a composition of erythrocyte. They are released from the lysis of erythrocyte. Objectives: to study free hemoglobin concentrations in surgical patients received massive blood transfusion (MBT). Subject and methods: 48 adult patients (male: 31 (64.6%), female: 17 (35.4%), mean age: 36 \xb1 16) with more than 3000ml of storage blood were tested for plasma free hemoglobin. The major reason for MBT were severe trauma (45.8%), the remainder were non - trauma. The change of Hb free was followed in 16 patients at the times of 1500 ml, 2000 ml, 3000 ml storage blood transfused (9 \xb1 3 days). Results: Plasma free hemoglobin was detected after 2,000ml of red cell transfusion and during the first 24h post MBT in 100% cases. Plasma free hemoglobin concentration trended to increase with quantity of transfused blood (0.56 \xb1 0.3 g/dl after 2000 ml, 0.76 \xb1 0.47 g/dl after 3000 ml, and 0.93 \xb1 0.41 g/dl after 5000 ml). There was no correlation between free hemoglobin concentration in plasma of patients with the storage time of blood transfused, and no difference of plasma free hemoglobin concentration between in trauma and non trauma patients. Conclusion: The blood with short time of storage is recommended after 1500ml blood transfusion in these patients. \r\n', u'\r\n', u'
Blood Transfusion ; Hemoglobins/ pharmacokinetics