Nine compounds derivated from 2-mercaptobezothiazole were synthesized. Their structure have been identified by MS-, IR-, and UV- spectroscopy. Antimicrobial activities of some compounds have been tested. Hydrazide BT6 and substituted hydrazides BT7, BT8, BT9 were found to have significant inhibitory activity on P. aeruginosa, S. aureus, Asp. niger and F. oxysporum at concentration 50mcg/ml.
Pharmaceutical Preparations

Realtime xCELLigence analysis (RTCA) is a new cell detection technology to continuously monitor, record and analyze a variety of information generated by cell activity. In drug research, it plays an important role in assessing myocardial toxicity and cell biological activity. Here, we first introduce the underlying mechanisms and characteristics of RTCA. Then we review the applications of RTCA in the research of myocardial toxicity and cell biological activity, to provides the fundamental baseline for understanding and exploiting RTCA. With the real-time, unlabeled, non-invasive, high throughput, and high accuracy features, RTCA not only promotes drug research and development, but also has a broad and good application prospect in other fields.
Pharmaceutical Preparations

According to the results of an investigation on 270 households in May 1999 carried out in Tien Son district, Bac Ninh province, 56 (20.79%) purchasing households came to commune health centre, 195 (72.22%) came to private clinic, 8 (2.96%) came to public pharmacy and 11 (4.03%) came to private pharmacy. Quality of the drug, easiness to access, reasonable price, good counseling... are the favorable factors to promote the purchaser's choice
Pharmaceutical Preparations ; Pharmaceutical Services

Testing of pharmaceutical dosage forms for in vitro drug release and dissolution characteristics is very important for ensuring batch-to-batch quality control and to optimize formulations during product development. The ideal system for evaluating the drug release characteristics of poorly water-soluble drug formulations (as nifedipine tablets) is to maintain “sink conditions”. Flow-through dissolution systems (e.g. USP XXIV apparatus 4) can be used to over come solubility limitations. In this study, a flow-through dissolution system was installed to evaluate two sustained release nifedipine tablets (Adalat retard 20 mg and Nifedipine retard 20 mg- Life Pharma). The dissolution profiles prove that this system with the pump rate of 14-16 ml/min offers a method to evaluate nifedipine tablets, especially sustained release formulations.
Nifedipine ; tablets ; Pharmaceutical Preparations

The bioavailability of amoxicilline for oral suspension was studied. The plasma concentrations of amoxicilline were measured by high pressure liquid chromatography (HPLC) using UV detector. The results of this study indicate that peak concentration (Cmax) of amoxicillin for oral suspension is 35.8 mcg/ml, time of peak concentration (tmax) is 1h and relative bioavailability is 137% and 169.5% comparing with capsules of Hamburg, pharmaceutical factory B, respectively.
Amoxicillin ; Pharmaceutical Preparations

The bioavailability of amoxiciline for oral suspension was determined using urinary excretion method. The average cumulative (mg) amoxiciline excreted after 24 hour for capsule (Hamburg), capsule (pharm.fac.B) and granule for suspension is 405.3mg, 341.2mg and 519.9mg, respectively.
Amoxicillin ; Pharmaceutical Preparations

We have prepared Triolone triacetate compound from 16-DPA. This is intermediate product for preparation of hydrocortisone by microbiological transformation. Analytical sample has proved in all respects with an authentic specimen
Pharmaceutical Preparations ; Pregnenediones

Safety ; Pharmaceutical Preparations

Our study included 14 patients admitted to Bachmai hospital because of headache and hypertension after taking anti-cold preparations (Rhumenol Decolgen, Decolsin, and Medicoldac) from 3/2002 to 6/2002. These patients had no history of hypertension and took antiflu tablets according to instruction of manufacturers. On admission, all patients had hypertension with the maximum BP 190/120mmHg. The first-degree atrioventricular block was observed in 1 case. The adverse effects may be caused by overdose of phenylpropanolamine, a sympathomimetic agent. Our study is a warning of dangerous reality of broadly advertising, marketing and abusing drugs. The manufacturers should consider the amount of Phenylpropanolamine in anti-cold preparations to avoid the adverse effect.
Pharmaceutical Preparations ; Adverse effects

The study was carried out in 36 grown-up rabbits with average weight 2±0,3kg. The results showed that: skin tissue exposed to oxidant was severe injury with necrosis area into muscle, bone and healing process was slow. Skin injury caused by burn substance was milder: main characteristics of skin lesions were congestion and edema, healing process is faster. Treatment of the skin lesions: spraying water on the contaminated area of the skin and application of B76 everyday was effective. Healing image of the skin tissue appeared early and fast.
Skin ; Pharmaceutical Preparations