Nine compounds derivated from 2-mercaptobezothiazole were synthesized. Their structure have been identified by MS-, IR-, and UV- spectroscopy. Antimicrobial activities of some compounds have been tested. Hydrazide BT6 and substituted hydrazides BT7, BT8, BT9 were found to have significant inhibitory activity on P. aeruginosa, S. aureus, Asp. niger and F. oxysporum at concentration 50mcg/ml.
Pharmaceutical Preparations

Realtime xCELLigence analysis (RTCA) is a new cell detection technology to continuously monitor, record and analyze a variety of information generated by cell activity. In drug research, it plays an important role in assessing myocardial toxicity and cell biological activity. Here, we first introduce the underlying mechanisms and characteristics of RTCA. Then we review the applications of RTCA in the research of myocardial toxicity and cell biological activity, to provides the fundamental baseline for understanding and exploiting RTCA. With the real-time, unlabeled, non-invasive, high throughput, and high accuracy features, RTCA not only promotes drug research and development, but also has a broad and good application prospect in other fields.
Pharmaceutical Preparations

According to the results of an investigation on 270 households in May 1999 carried out in Tien Son district, Bac Ninh province, 56 (20.79%) purchasing households came to commune health centre, 195 (72.22%) came to private clinic, 8 (2.96%) came to public pharmacy and 11 (4.03%) came to private pharmacy. Quality of the drug, easiness to access, reasonable price, good counseling... are the favorable factors to promote the purchaser's choice
Pharmaceutical Preparations ; Pharmaceutical Services

Using MIMS-interactive software-a computerized drug interaction screening program for detecting and classifying drug interactions in 3 clinical departments showed that drug interaction was quite common (the rate medical reports with drug interaction at genito-urinary department was 85.15%, abdominal surgery department was 67.195, cardiovascular surgery department was 78.95%). However most of these had no clinical significance. The rate of drug interaction with clinical significance at genito-urinary department was only 3.48%, abdominal surgery department 7.03%, cardiovascular department 3.29%. Applying software helps doctors find and treat adverse drug interactions timely, which can increase the safety of efficiency of prescriptions, especially for surgical treatment which require rapid and accurate treatment
Drug Interactions ; Pharmaceutical Preparations

A statistic investigation was conducted on all species of animals as a whole with their distribution, their status of existence up to the year 2003.There are 408 species including 22 classes, 6 branches of animal which had been used and had been identified in Vietnam. Among them, 393 species have been living in wild nature, their 152 species were registered into Vietnam’s Red Book. According to the APPENDIX of The Decree n.48/2002/ND-CP and The Appendix of CITES_ Guide to Plants and Animals in Trade, Authors had Recommended the use of breeding animals instead of wild animals
animals ; medicine ; Pharmaceutical Preparations

The excellent achievement of encoding human gene strongly impacted not only to medicine but also pharmacy. Based on knowledge of human genome, one new speciality appears in pharmacy, it is Pharmacogenomics, studies in the effects and side-effects of drugs, and finds out the new produce methods based on gene. The main technologies in Pharmacogenomics are molecular biotechnology, gene technology, molecular enzyme, especially SNPs technique. Pharmacogenomics gained many important achievements in improving of drug effects, especially drugs for treating of neuropathy and cardiovascular diseases, in studying drug resistance of bacteria, virus. Targets are 'personalized pharmacy' to produce, provide for each patient drug that appropriate to his genome in order to optimize drug effects, minimally or completely reduce side-effects
Pharmacogenetics ; Genome ; Pharmaceutical Preparations ;

After The 6th Party Congress, Vietnam pharmaceutical industry prospered, especially in 1990s. Pharmaceutical industry was rising; drug market in Vietnam became eventful and plentiful, responded more and more effectively for the healthcare needs of people. The author mentioned situations of pharmaceutical production and trade in Vietnam during 1996-2002 period: kinds of pharmaceutical companies, situation of drug use, situation of production and trade of Vietnamese pharmaceutical companies and ensuring drug quality
Drug Industry ; Pharmaceutical Preparations

Researching synthetic method of Dehydropregnenolon acetat (DPA, 3β-acetoxy-pregn-5, 16-dien-20-on) from 3β- acetoxy-pregn-5-en 17β-ol-20-yn, a conclusion is given that using this method dicobalt hexacarbonyl was created in the first time in group acethylen, 3β- acetoxy-pregn-5-en 17β-ol-20-yn is synthesized with good output from equivalent 17β- hydroxy derivative. Respond not attach generates auxiliary products like known methods. Through two methods hydrating and hydrating in gentle conditions, dehydro pregnenolon acetat is synthesized with quite good output from 3β- acetoxy-pregn-5-en 17β-ol-20-yn. Intermediary compounds and final products characterized by melt point, infared spectrum, proton magnetic spectrum and weight spectrum
Pregnenolone ; Pharmaceutical Preparations

Comparative bioavailability study of rifampicin from 2-FDC and 3- FDC with standard separate tablets at the same dose level was conducted in 12 healthy volunteers. The study was designed as a cross-over experiment with a washout period of 1 week. Bioavailability of rifampicin was estimated by plasma concentration of rifampicin from Oh to 24h after dosed. Plasma rifampicin concentration was determined by HPLC method. The results revealed that: Cmax and AVC for rifampicin in 2-FDC and 3FDC formulation were lower (but Tmax were higher) than the standard separate formulations. It was concluded that FDC tablets are of poor relative bioavailabity of rifampicin. The implication for National Tuberculosis Programme is extremely serious and warrants urgent attention
Tuberculosis ; Pharmaceutical Preparations ; Therapeutics

The analgesic efficacy of Morphin sulfate capsule 30mg manufactured domestically was evaluated in 59 cancer patients. Time of action onset after the first 30mg dose was 15-60 minutes (35-45 min in 70.6% patients) and the analgesic effect lasted from 2.5 to 12 hrs (4-5 hrs in 59.3% patients), depending on patients' pain score prior to administration of drug. Generally, 77.9%, 11.9% and 10.2% patients acquired good, moderate and poor results from analgesic treatment, respectively
Analgesics ; Pharmaceutical Preparations ; Morphine